Beclomethasone dipropionate Easyhaler is as effective as budesonide Turbohaler in the control of asthma and is preferred by patients. German Study Group.

Abstract:

:This randomised, crossover study compared the efficacy, safety, acceptability and patient preference of two multidose powder inhalers (MDPIs)--beclomethasone dipropionate Easyhaler (BDP-EH) and budesonide Turbohaler (BUD-TH)--in 79 stable asthmatics who used inhaled steroids but had no experience of MDPIs. After eight weeks' treatment a mean increase in morning PEF of 16 l/min from a baseline of 356 +/- 112 l/min was observed for each treatment. Similar improvements occurred in evening PEF, FEV1, FVC and asthma symptoms. Both treatments had only minimal effect on morning serum cortisol levels. Compliance with both treatments was high (> 97%) but almost twice as many patients favoured the EH (59%) compared with the TH (33%); 7% rated the devices equally. Scores of device acceptability were significantly in favour of the EH (p = 0.001). BDP-EH and BUD-TH showed comparable efficacy and safety in the treatment of asthma. Each MDPI had a high rate of compliance, but patients registered greater preference for the EH than the TH.

journal_name

Int J Clin Pract

authors

Jäger L,Laurikainen K,Leinonen M,Silvasti M

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

368-72

issue

6

eissn

1368-5031

issn

1742-1241

journal_volume

54

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    pub_type: 杂志文章

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    doi:10.1111/j.1742-1241.2010.02337.x

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    doi:

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    更新日期:2002-01-01 00:00:00

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    doi:10.1111/ijcp.13253

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    journal_title:International journal of clinical practice

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    更新日期:2002-04-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2002-05-01 00:00:00

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