Catecholamine secretion and ploidy in phaeochromocytoma.

Abstract:

:The aim was to evaluate 24 hr urine catecholamine, HMMA and HVA excretion in relation to ploidy in phaeochromocytoma. Data from five diploid and nine tetraploid tumours showed a significant reduction in urine noradrenaline (p = 0.02) and HMMA (p = 0.03) in diploid tumours but no difference in adrenaline, dopamine and HVA excretion using the Mann-Whitney U test. None of the patients showed recurrence after a mean of 5.7 years of follow up. A review of published ploidy studies in phaeochromocytoma shows that malignancy is more than six times more common in non-diploid tumours but diploidy does not equate with benignity. No biochemical marker is a reliable index of malignancy. All patients should undergo lifetime review for recurrence.

journal_name

Int J Clin Pract

authors

Tormey WP,Fitzgerald RJ,Thomas G,Kay EW,Leader MB

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

520-3

issue

8

eissn

1368-5031

issn

1742-1241

journal_volume

54

pub_type

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