Severe pulmonary haemorrhage accompanying hepatorenal failure in fulminant leptospirosis.

Abstract:

:Leptospirosis is a re-emerging spirochetal zoonosis with a worldwide distribution affecting both animals and humans. The clinical syndromes may vary from a subclinical infection to a severe illness. Although it may potentially have a fulminant and fatal course, leptospirosis usually remains as an underdiagnosed cause of multiorgan failure. In this study, we report a patient with leptospirosis who presented with a fulminant course of diffuse alveolar haemorrhage and hepatorenal failure. His clinical condition deteriorated, despite appropriate antibiotic therapy and haemodialysis. However, he showed prompt clinical improvement when corticosteroids and plasma exchange were instituted in addition to the original therapy. We conclude that leptospirosis should be considered in any case presenting with pulmonary haemorrhage and hepatorenal failure. Plasma exchange and corticosteroids may be a choice of treatment in selected patients unresponsive to conventional therapy. Potential benefits of plasma exchange and corticosteroids may be based on a toxin- and/or cytokine-mediated pathogenesis of the disease.

journal_name

Int J Clin Pract

authors

Dursun B,Bostan F,Artac M,Varan HI,Suleymanlar G

doi

10.1111/j.1742-1241.2005.00638.x

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

164-7

issue

1

eissn

1368-5031

issn

1742-1241

pii

IJCP638

journal_volume

61

pub_type

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