Abstract:
:Leptospirosis is a re-emerging spirochetal zoonosis with a worldwide distribution affecting both animals and humans. The clinical syndromes may vary from a subclinical infection to a severe illness. Although it may potentially have a fulminant and fatal course, leptospirosis usually remains as an underdiagnosed cause of multiorgan failure. In this study, we report a patient with leptospirosis who presented with a fulminant course of diffuse alveolar haemorrhage and hepatorenal failure. His clinical condition deteriorated, despite appropriate antibiotic therapy and haemodialysis. However, he showed prompt clinical improvement when corticosteroids and plasma exchange were instituted in addition to the original therapy. We conclude that leptospirosis should be considered in any case presenting with pulmonary haemorrhage and hepatorenal failure. Plasma exchange and corticosteroids may be a choice of treatment in selected patients unresponsive to conventional therapy. Potential benefits of plasma exchange and corticosteroids may be based on a toxin- and/or cytokine-mediated pathogenesis of the disease.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Dursun B,Bostan F,Artac M,Varan HI,Suleymanlar Gdoi
10.1111/j.1742-1241.2005.00638.xsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
164-7issue
1eissn
1368-5031issn
1742-1241pii
IJCP638journal_volume
61pub_type
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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journal_title:International journal of clinical practice
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更新日期:2000-10-01 00:00:00
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journal_title:International journal of clinical practice
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