Abstract:
BACKGROUND:Erectile dysfunction (ED) is a common medical condition. In the UK, approximately 2.3 million men suffer from moderate-to-severe ED, many of whom do not consult a healthcare professional about the problem. Phosphodiesterase-type 5 (PDE5) inhibitors have revolutionised treatment for ED and three such drugs are currently available: sildenafil citrate, tadalafil and vardenafil HCl. METHODS:This article reviews available information on the efficacy and safety of tadalafil for the treatment of ED, with a focus on clinical experience in the UK. RESULTS:The clinical effects of tadalafil have been shown to last for up to 36 h after administration, longer than the other PDE5 inhibitors, which are effective for only 4-5 h after dosing. Extensive clinical experience with tadalafil, worldwide and in the UK, supports its efficacy and tolerability in many patient populations, including those with comorbidities often associated with ED. CONCLUSIONS:Studies have shown that tadalafil is an effective ED treatment, regardless of disease severity and cause, patient age and presence of comorbid conditions. As the treatments for ED have evolved, patient preference has emerged as an important aspect of ED therapy.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Dinsmore Wdoi
10.1111/j.1742-1241.2009.02123.xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
1231-6issue
8eissn
1368-5031issn
1742-1241pii
IJCP2123journal_volume
63pub_type
杂志文章,评审abstract::Randomised controlled trials evaluating the effect of statin use on maintenance of normal sinus rhythm (NSR) after electrical cardioversion (ECV) of persistent atrial fibrillation (AF) have demonstrated conflicting results. However, many of these trials were of relatively small size and thus underpowered to adequately...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1742-1241.2010.02387.x
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:In the setting of an increasing workload for radiologists, this study focuses on the feasibility of skill mixing in breast imaging in a hospital radiology department. METHODS:Two radiological technologists with more than 10 years of experience in performing mammograms were trained in prereading mammograms to s...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2009.02310.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate the use of computed tomography (CT) as the first imaging modality in patients with renal colic and microscopic haematuria. METHODOLOGY:The patients that presented to the emergency service of six health centers with renal colic between January 2017 and January 2018 and were found to have ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13826
更新日期:2020-11-09 00:00:00
abstract:OBJECTIVE:The objective of this study was to investigate the relationship between the use of medicinal plants and medication adherence in elderly people. METHODS:Observational, cross-sectional study of elderly residents in Cuité-PB, Northeastern Brazil, through a household survey. A stratified proportional and systema...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12773
更新日期:2016-03-01 00:00:00
abstract::Respiratory physicians often encounter patients with chronic cough. The evaluation and outcome of such patients by centres with established diagnostic protocols has been well described. By contrast, little is known about patients referred to general respiratory clinics where no such protocol exists. We describe the fi...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:AIM:Variations of dopamine receptor type 2 (DRD2) are among the key factors involved in the pathology of schizophrenia. Presence of certain SNPs in DRD2 gene also amend patients' response to antipsychotics. Keeping in view the genetic diversity among populations and important role of DRD2 polymorphisms in schizophrenia...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13536
更新日期:2020-09-01 00:00:00
abstract:AIMS:Although many elderly individuals suffer from type 2 diabetes, the effectiveness of cardioprotective drugs in primary prevention of cardiovascular events in clinical practice in this population has rarely been evaluated. We aimed to assess the effectiveness of, (i) angiotensin converting enzyme inhibitors or angio...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/ijcp.12503
更新日期:2015-03-01 00:00:00
abstract:AIM:To evaluate whether administration of long-acting basal insulin analogue plus oral antidiabetic drugs (OADs) improves glycaemic control in type 2 diabetic patients with glycosylated haemoglobin (HbA1c) > 7% (53 mmol/mol) under premixed insulin therapy. METHODS:This is a multicentre, observational, retrospective st...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1742-1241.2012.03000.x
更新日期:2012-10-01 00:00:00
abstract::This double-blind, randomised placebo-controlled, multicentre study evaluated the efficacy, tolerability and safety of 12 weeks' treatment with controlled release darifenacin 15 mg once daily (qd), in 445 patients with overactive bladder (OAB). The primary endpoint was warning time (time from first sensation of urgenc...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1368-5031.2005.00770.x
更新日期:2006-01-01 00:00:00
abstract:AIMS:To describe the mechanisms of action of denosumab, a novel antiresorptive agent, contrasting it with other antiresorptive and anabolic osteoporosis treatments. METHODS:Published papers related to the mechanism of action of approved osteoporosis treatments were sought through MEDLINE searches. FINDINGS:Osteoporot...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/ijcp.12022
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Restrictions imposed for the COVID-19 pandemic and the people's fear of getting infected have caused a significant drop in the number of emergency service admissions. Herein, we aimed to investigate the reflections of our otherwise crowded emergency services' quietness in the period of normalisation. METHODO...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13912
更新日期:2021-02-01 00:00:00
abstract::Leptospirosis is a re-emerging spirochetal zoonosis with a worldwide distribution affecting both animals and humans. The clinical syndromes may vary from a subclinical infection to a severe illness. Although it may potentially have a fulminant and fatal course, leptospirosis usually remains as an underdiagnosed cause ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2005.00638.x
更新日期:2007-01-01 00:00:00
abstract::To investigate ethnic differences and the effect of age and education on awareness and attitudes of women towards hormone replacement therapy (HRT), we conducted a questionnaire survey of 180 women attending a gynaecology clinic, of whom 152 (84.4%) responded. Seventy-one of the women had heard of HRT. Awareness of HR...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::A high prevalence of newly detected diabetes mellitus (DM) and impaired glucose tolerance (IGT) has been reported in patients with acute myocardial infarction (AMI) and no previous diagnosis of DM. However, the prevalence of newly detected DM is grossly underestimated by using fasting plasma glucose (FPG). We determin...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01301.x
更新日期:2007-04-01 00:00:00
abstract::In this prospective qualitative study over 12 months, we evaluated the educational and clinical effectiveness of a new final year undergraduate programme in a London medical school (Guy's, King's and St Thomas'). A stratified sample of 17/360 final year students were interviewed four times, and the content was assesse...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2005.00438.x
更新日期:2005-03-01 00:00:00
abstract:AIMS:Investigate if angiotensin II receptor blocker (ARB) decreases risk of upper gastrointestinal bleeding (UGIB) in hypertensive patients with chronic kidney disease (CKD) not on dialysis. METHODS:All hypertensive patients with CKD not on dialysis in outpatient department of China Medical University Hospital from 20...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12589
更新日期:2015-07-01 00:00:00
abstract::In a five-year retrospective data analysis, incidence of > stage II necrotising enterocolitis (NEC) was four times higher in aboriginal (18/125) than non-aboriginal (11/306) neonates, all < or = 32 weeks' gestation. Stage III NEC occurred more frequently (10/18 vs 3/11) and related mortality was higher (44.4% vs 0%) i...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Guidelines for injury care are increasingly moving away from surgical management towards less invasive procedures but there is a knowledge gap on how these recommendations are influencing practice. We aimed to assess inter-hospital variation in surgical intensity for injury admissions and evaluate the correl...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13613
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Whilst core curricula in neurology are nationally standardised, in real-world clinical practice, different approaches may be taken by individual consultants. The aims of this study were to investigate differences by assessing: (a) variance in diagnostic and investigative practice, using a case-based analysis of...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13830
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:People with depressive disorders or subsyndromal symptoms of depression (SSD) often use complementary and alternative therapies, including massage therapy (MT). This systematic review evaluates the evidence, from randomised clinical trials (RCTs), for the effectiveness of multiple sessions of classical Europ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2007.01553.x
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Emerging research demonstrates an interrelationship between systemic inflammation, physical activity and premature all-cause mortality among chronic obstructive pulmonary disease (COPD) patients. Less common in this literature is the use of objective measures of physical activity and representative samples o...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12778
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND AND AIMS:The use of herbs and dietary supplements (HDS) alone or concomitantly with medications can potentially increase the risk of adverse events experienced by the patients. This review aims to evaluate the documented HDS-drug interactions and contraindications. METHODS:A structured literature review was...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2012.03008.x
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:There is abundant evidence that patients with rheumatoid arthritis (RA) are at elevated cardiovascular (CV) risk. The contribution of lipids in general is well recognised, but is as yet unclear in inflammatory diseases such as RA in part because inflammation appears inversely associated with lipid levels in ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2009.02220.x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Inappropriate drug prescribing has increased especially in developing countries where systems for monitoring medicine use are not well developed. This increases the rate of antimicrobial resistance. The study aim was to assess the prescribing patterns among urban primary health facilities in Botswan...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13042
更新日期:2017-12-01 00:00:00
abstract:AIMS:Intervention studies have shown that angiotensin receptor blockers (ARB) may reduce the incidence of type 2 diabetes mellitus. It is currently unclear whether short-term therapy with ARBs affects metabolic parameters. METHODS:i-RESPOND, a randomised, controlled, multicentre, double-blind study evaluated the effec...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1742-1241.2009.02246.x
更新日期:2010-01-01 00:00:00
abstract::Asthma treatment is suboptimal in many patients, with impacts on morbidity and mortality, healthcare resource utilisation and patients' quality of life. The reasons for this include the inherent variability of asthma and the unpredictability of exacerbations, which can range from mild to fatal. In addition, asthma can...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2004.00182.x
更新日期:2004-06-01 00:00:00
abstract::The management approach to non-insulin-dependent diabetes mellitus among family doctors in Hong Kong was studied using two case histories. In 1996, all 804 fellows, members and associate members of the Hong Kong College of Family Physicians were sent a letter and a questionnaire. Of the 512 who responded, 405 were mal...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To conduct a comparative study of retinal nerve fibre layer (RNFL) thickness and choroidal thickness of psoriasis patients and healthy volunteers. METHODS:This study included 35 severe psoriasis patients, 35 mild psoriasis patients and 35 healthy individuals. RNFL and choroidal thickness analysis...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13904
更新日期:2020-12-08 00:00:00
abstract::Erectile Dysfunction (ED) is common in men with diabetes. Diabetic men are three times as likely to develop ED as non-diabetic men. The cause is multifactorial, but most commonly reflects endothelial dysfunction and autonomic neuropathy. Diabetes and vascular disease often coexist and ED may be a marker for silent occ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2004.00180.x
更新日期:2004-04-01 00:00:00
abstract::Monomeric prolactin (PRL) of molecular weight 23 kDa constitutes up to 95% of adult serum PRL. Macroprolactin is a large antigen-antibody complex of molecular weight greater than 100 kDa and constitutes less than 1% of circulating PRL. Thus, in most cases, hyperprolactinaemia is usually a result of high levels of mono...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2006.00732.x
更新日期:2006-04-01 00:00:00