Abstract:
:How the intrinsic sequence structure of neonatal mouse pup ultrasonic vocalization (USV) and maternal experiences determine maternal behaviors in mice is poorly understood. Our previous work showed that pups with a Tbx1 heterozygous (HT) mutation, a genetic risk for autism spectrum disorder (ASD), emit altered call sequences that do not induce maternal approach behaviors in C57BL6/J mothers. Here, we tested how maternal approach behaviors induced by wild-type and HT USVs are influenced by the mother's experience in raising pups of these two genotypes. The results showed that wild-type USVs were effective in inducing maternal approach behaviors when mothers raised wild-type but not HT pups. The USVs of HT pups were ineffective regardless of whether mothers raised HT or wild-type pups. However, the sequence structure of pup USVs had no effect on the general, non-directional incentive motivation of maternal behaviors. Our data show how the mother's experience with a pup with a genetic risk for ASD alters the intrinsic incentive values of USV sequences in maternal approach behaviors.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Kato R,Machida A,Nomoto K,Kang G,Hiramoto T,Tanigaki K,Mogi K,Hiroi N,Kikusui Tdoi
10.1002/dev.22006subject
Has Abstractpub_date
2021-01-01 00:00:00pages
108-113issue
1eissn
0012-1630issn
1098-2302journal_volume
63pub_type
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