Abstract：
:Biological scaffolds used in tissue engineering are incorporated in vivo by a process of cellular in-growth, followed by host-mediated degradation and replacement of these scaffolds, in which phagocytic cells from the monocyte/macrophage cell lineage play a key role. The chemical degradation of scaffolds with collagenases is well established, but to date this has not been correlated with an in vitro model of cell mediated scaffold degradation. RAW264.7, a murine monocyte/macrophage cell line, was cultured on collagen scaffolds crosslinked either by dehydrothermal treatment (DHT) or by carbodiimide (EDC). These cells attached to collagen scaffolds, proliferated and exhibited macrophage aggregation to form giant cells. Crosslinking the scaffolds by either DHT or EDC increased the resistance of the scaffold to degradation by macrophages. Increasing the amount of crosslinking in the scaffold made them more resistant to degradation by collagenase. However, while EDC increased the scaffolds' thermal and mechanical properties and decreased the swelling ratio, DHT increased the mechanical properties, but decreased the denaturation temperature and swelling ratio. Altering the scaffold properties by crosslinking affects the rate of degradation by macrophages, and this is correlated with chemical degradation (r=0.658, p<0.01). This will help in the design of scaffolds with task-specific profiles for use in tissue engineering.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Yahyouche A,Zhidao X,Czernuszka JT,Clover AJdoi
10.1016/j.actbio.2010.08.005subject
Has Abstractpub_date
2011-01-01 00:00:00pages
278-86issue
1eissn
1742-7061issn
1878-7568pii
S1742-7061(10)00366-1journal_volume
7pub_type
杂志文章abstract：UNLABELLED:Antimicrobial peptides (AMPs) are good candidates to treat burn wounds, a major cause of morbidity, impaired life quality and resources consumption in developed countries. We took advantage of a commercially available hydrogel, Carbopol®, a vehicle for topical administration that maintains a moist environmen...
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journal_title：Acta biomaterialia
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更新日期：2010-08-01 00:00:00
abstract：:Magnesium (Mg) medical devices are currently being marketed for orthopedic applications and have a complex degradation process which includes the evolution of hydrogen gas (H2). The effect of H2 exposure on relevant cell types has not been studied; and the concentration surrounding degrading Mg devices has not been qu...
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journal_title：Acta biomaterialia
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2018.03.015
更新日期：2018-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2012.04.021
更新日期：2012-08-01 00:00:00
abstract：:During the past two decades, research on ceramic scaffolds for bone regeneration has progressed rapidly; however, currently available porous scaffolds remain unsuitable for load-bearing applications. The key to success is to apply microstructural design strategies to develop ceramic scaffolds with mechanical propertie...
journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2013.02.039
更新日期：2013-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2012.01.030
更新日期：2012-07-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2019.04.055
更新日期：2019-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2018.03.007
更新日期：2018-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2015.02.021
更新日期：2015-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2011.09.033
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
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更新日期：2013-11-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2013-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2017.02.022
更新日期：2017-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2016.03.023
更新日期：2016-08-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2016.08.044
更新日期：2016-11-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
abstract：:A new series of beta Ti-Nb-Zr (TNZ) alloys with considerable plastic deformation ability during compression test, high elastic admissible strain, and excellent cytocompatibility have been developed for removable bone tissue implant applications. TNZ alloys with nominal compositions of Ti-34Nb-25Zr, Ti-30Nb-32Zr, Ti-28...
journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2015.03.023
更新日期：2015-07-01 00:00:00
