Abstract：
:Recombinant proteins directed against the circumsporozoite (CS) protein of Plasmodium vivax were tested for safety, immunogenicity, and efficacy in Saimiri sciureus boliviensis monkeys. The monkeys were immunized 3 times with either alum or muramyl tripeptide as adjuvant, and were challenged with 10,000 sporozoites (P. vivax, Salvador I strain) from mosquitos infected by membrane feeding on gametocytes from chimpanzees. Antibodies, measured by indirect immunofluorescent antibody tests and enzyme-linked immunosorbent assays, were induced by all the vaccines. Six of 42 monkeys immunized with recombinant or synthetically produced vaccines were protected. Two of 6 monkeys immunized with irradiated sporozoites were protected. Saimiri appear to be less susceptible than are humans to sporozoite infection. Therefore, the predictive usefulness of this model must await the results of comparable trials in monkeys and humans.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Collins WEsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
42-6eissn
0042-9686issn
1564-0604journal_volume
68 Supplpub_type
杂志文章abstract：:A serological survey was conducted among Tuareg nomads to determine their level of immunity to measles. More than half (57.9%) of the children under 10 years of age did not have detectable antibodies to measles, suggesting that transmission of the disease is low in this mobile population. Mothers' reports of their chi...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Described are the results of an international collaborative study to evaluate the use of whole blood samples spotted on filter-paper (BSP) for the detection of antibodies to human immunodeficiency virus type 1 (HIV-1). BSP samples were collected from 40 patients at risk for HIV-1 infection and tested blindly using com...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:In a case-control study we examined the association of Plasmodium falciparum circumsporozoite antibodies (anti-R32tet32) with subsequent P. falciparum infections. A study population of 140 children living in an endemic area was followed longitudinally for 25 weeks with weekly blood smears for malaria parasites and, on...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:This paper reviews recent experimental evidence in support of inoculation with antirabies serum, the value of which, as a prophylactic measure, is compared with that of vaccine treatment alone. The author concludes that the chief advantages of combined antiserum-vaccine prophylaxis lie in the rapid treatment of cases ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1954-01-01 00:00:00
abstract：OBJECTIVE:We aimed to determine the burden of bacillary dysentery in China, its cross-regional variations, trends in morbidity and mortality, the causative bacterial species and antimicrobial resistance patterns. METHODS:We extracted and integrated governmental statistics and relevant medical literature published from...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.05.023853
更新日期：2006-07-01 00:00:00
abstract：:This report presents the results of a six-month survey of the nature and extent of venereal diseases in Turkey which was undertaken by the author, on behalf of WHO, at the request of the Turkish Government. The first part of the report outlines the present venereal-disease-control system and includes descriptions of t...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1954-01-01 00:00:00
abstract：:Three diphtheria toxoid preparations, fractionated at various concentrations of ammonium sulfate, having various grades of purity, and showing striking differences in immunizing potency when compared at the same Lf dose, were examined for similarity of the effective constituents in the fractions. No evidence of deviat...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1954-01-01 00:00:00
abstract：:This paper synthesizes the rates, barriers, and outcomes of HIV serostatus disclosure among women in developing countries. We identified 17 studies from peer-reviewed journals and international conference abstracts--15 from sub-Saharan Africa and 2 from south-east Asia--that included information on either the rates, b...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2004-04-01 00:00:00
abstract：:The use of BCG vaccine in the prevention of leprosy has been one of the most important subjects of investigation in the field of leprology in the last 25 years. The action of the vaccine was for many years investigated by determining its effect on the lepromin reaction. Field studies were later considered essential to...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:Notifications of morbidity are frequently incomplete but they represent the only practicable way of carrying out large-scale surveillance. Studies of hepatitis in the Central District of Israel offered an opportunity of assessing the reliability of routine data. The regular canvassing of physicians resulted in a 2-3-f...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:In the course of a research project on atherosclerosis, an international group of pathologists studied lesions in the aorta and coronary arteries obtained at autopsy from 3174 subjects from Czechoslovakia, Sweden and the USSR in an effort to determine what factors, recognizable in life, might be used to predict the pr...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1965-01-01 00:00:00
abstract：OBJECTIVE:To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in Africa, the Americas, South-East Asia and the Western Pacific. METHODS:A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.14.139113
更新日期：2015-02-01 00:00:00
abstract：:The author reviews the agricultural use of night-soil, sewage, and sewage sludge from two points of view: the purely agricultural and the sanitary.Knowledge of the chemistry and bacteriology of human faecal matter is still rather scant, and much further work has to be done to find practical ways of digesting night-soi...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1954-01-01 00:00:00
abstract：OBJECTIVE:To quantify long-term health service use (HSU) following non-fatal injury in adults. METHODS:A retrospective, population-based, matched cohort study identified an inception cohort (1988-91) of injured people who had been hospitalized (ICD-9-CM 800-995) aged 18-64 years (n = 21 032) and a matched non-injured ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.06.030833
更新日期：2006-10-01 00:00:00
abstract：:Advancing the public health insurance system is one of the key strategies of the Senegalese government for achieving universal health coverage. In 2013, the government launched a universal health financial protection programme, la Couverture Maladie Universelle. One of the programme's aims was to establish a community...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.19.239665
更新日期：2020-02-01 00:00:00
abstract：:A WHO-coordinated study of the community control of hypertension in six countries (Cuba, Finland, France, Italy, Mongolia and Portugal) has shown that a comprehensive approach clearly improves the care of hypertensives in various populations. Hypertension control programmes were individually designed in each country a...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The occurrence of three deaths and substantial morbidity among members of a "package tour" who stayed at the same hotel in Benidorm, Spain, during the summer of 1973 provided an opportunity to study the experiences of persons undertaking this type of holiday and some of the factors that might affect their health. Of 2...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Reported are the results of a randomized, double-masked, placebo-controlled trial of annual ivermectin dosing in 34 rural communities, Kaduna State, northern Nigeria, where guinea savanna onchocerciasis is mesoendemic. A total of 939 individuals underwent Friedmann field analysis at the first examination and saw at le...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1997-01-01 00:00:00
abstract：:A modified ovitrap from which larvae could not escape was employed for one year for the control of Aedes aegypti at Blossom Heights, Houston, Texas. At the end of this period, the Breteau index in the ovitrap area had declined by 36%, in contrast to a sharp increase of nearly 500% in the non-ovitrap area. The premises...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:A number of drugs and drug combinations were tested both in vitro and in vivo against pathogens causing actinomycetoma and maduromycetoma. Of 144 patients with actinomycetoma treated, 63.2% were cured, 21.5% showed great improvement in their condition, and 11.1% showed some improvement. Treatment was successful even w...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Although none of the currently available methods of contraception can be considered ideal for use by adolescents, many come reasonably close. The present article reviews the relative benefits and risks associated with each method. Oral contraceptives (OCs) appear to bear few specific risks for adolescents. Pills co...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The study procedures and the results of blood pressure screening from 8 centres are reported. Data are also presented on age, sex, sexual maturity for girls, height, weight, Quetelet's index, smoking, and use of antihypertensive drugs for 92.1% of the 18 609 children born in 1964 in the 8 districts and surveyed in 197...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：OBJECTIVE:To determine whether integrating antiretroviral therapy (ART) into antenatal care (ANC) and maternal and child health (MCH) clinics could improve programmatic and patient outcomes. METHODS:The authors systematically searched PubMed, Embase, African Index Medicus and LiLACS for randomized controlled trials, p...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.12.107003
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:We sought to assess the current status of global data on death registration and to examine several indicators of data completeness and quality. METHODS:We summarized the availability of death registration data by year and country. Indicators of data quality were assessed for each country and included the tim...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：/S0042-96862005000300009
更新日期：2005-03-01 00:00:00
abstract：Objective:To analyse and improve the Namibian maternity care system by implementing maternal near-miss surveillance during 1 October 2018 and 31 March 2019, and identifying the challenges and benefits of such data collection. Methods:From the results of an initial feasibility study, we adapted the World Health Organiz...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.20.251371
更新日期：2020-08-01 00:00:00
abstract：:Investigators using questionnaires are usually confronted with an enormous number of different responses whose significance with respect to a particular characteristic is not immediately clear. This paper presents a simple computational technique for determining the relative merits of each question and a score for eac...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：OBJECTIVE:To investigate, in Amhara, Ethiopia, the association between prevalence of active trachoma among children aged 1-9 years and community sanitation usage. METHODS:Between 2011 and 2014, prevalence of trachoma and household pit latrine usage were measured in five population-based cross-sectional surveys. Data o...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.16.177758
更新日期：2017-04-01 00:00:00
abstract：:The nature of psychiatric disorders in tropical regions is affected much more by the effect on the patient of certain environmental and cultural factors than by any specific features of tropical diseases. In places where the standards of health care and health education are not yet fully developed, abnormalities of ph...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The ParaSight(R)-F test is a qualitative diagnostic test of Plasmodium falciparum, which is based on the detection by a monoclonal antibody of a species-specific soluble antigen (histidine-rich protein (HRP-II)) in whole blood and which can be performed without special equipment. A visual reading is given by a polyclo...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-01-01 00:00:00
abstract：:Reported is the use of a simplified methodology for carrying out a community-based epidemiological assessment that is compatible with the goals of primary health care research. For this purpose, a current-status life table analysis of data from 1131 women who were served by community health workers in the State of Méx...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
