Abstract:
:The ability to perform organic reactions with chemoselectivity is of critical importance in synthesis. Recently, we reported that a de novo carbene transferase, a tetra-α-helical c-type heme-containing protein, C45, is proficient at N-H insertion reactions, proceeding via the intermolecular transfer of a metallocarbenoid intermediate into the N-H σ-bond to form a new N-C σ-bond. Here we demonstrate that C45 can also catalyse N-H insertion reactions chemoselectively, even when the substrate contains an unprotected hydroxyl group.
journal_name
Biotechnol Appl Biochemjournal_title
Biotechnology and applied biochemistryauthors
Stenner R,Anderson JLRdoi
10.1002/bab.1924subject
Has Abstractpub_date
2020-07-01 00:00:00pages
527-535issue
4eissn
0885-4513issn
1470-8744journal_volume
67pub_type
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