Impaired L-arginine uptake in platelets from type-2 diabetic patients.

Abstract:

:The L-arginine uptake of resting platelets from type-2 diabetic patients and control subjects was measured and the kinetic parameters defined. The effect of platelet stimulation with agonists was also investigated. Kinetic studies showed that the K(m) value for L-arginine transport was not different in patients compared with control subjects, while V(max) was significantly decreased in patients compared with controls. Moreover, agonists able to mobilize Ca(2+) produced a further decrease in the L-arginine uptake in controls and in patients, suggesting that Ca(2+) intracellular levels down-regulate L-arginine transport in platelets from both control subjects and patients. Data suggest that drugs designed to control intracellular Ca(2+) might restore platelet function in diabetic patients.

authors

Signorello MG,Giovine M,Pascale R,Cataldi L,Bordone C,Benatti U,Leoncini G

doi

10.1042/ba20010022

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

19-23

issue

1

eissn

0885-4513

issn

1470-8744

journal_volume

34

pub_type

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