Abstract：
:Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embryonic stem cells. Nevertheless, upon their differentiation into neurons, circadian gene expression was observed. In the first steps along the pathway from ES cells to neurons, a neural precursor cell (NPC) line already showed robust circadian oscillations. Therefore, at a cellular level, the circadian clock likely begins at the very earliest stages of mammalian development.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Kowalska E,Moriggi E,Bauer C,Dibner C,Brown SAdoi
10.1177/0748730410385281subject
Has Abstractpub_date
2010-12-01 00:00:00pages
442-9issue
6eissn
0748-7304issn
1552-4531pii
25/6/442journal_volume
25pub_type
杂志文章abstract：:Reduced sensitivity to short-wavelength (blue) light with age has been shown for light-induced melatonin suppression. The current research aimed to determine if a similar age-related reduction occurs in subjective alertness, mood, and circadian phase-advancing responses. Young (n = 11, 23.0 +/- 2.9 years) and older (n...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730408328973
更新日期：2009-02-01 00:00:00
abstract：:A single light episode during the first larval stage can set the phase of adult Drosophila activity rhythms, showing that a light-sensitive circadian clock is functional in larvae and is capable of keeping time throughout development. These behavioral data are supported by the finding that neurons expressing clock pro...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730403260621
更新日期：2004-02-01 00:00:00
abstract：:Among the scientific resources that Colin Pittendrigh passed on to his colleagues after his death in 1996 were two unpublished papers. These manuscripts, developed first in the mid-1960s and continually updated and refined through the late 1970s, centered on the development and experimental exploration of a model of c...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417716685
更新日期：2017-08-01 00:00:00
abstract：:Almost exclusively, photoperiodic insects respond to a given photoperiod in one of two ways: a "long-day" response or a "short-day" response. Intermediate responses occur only at a very restricted range of photoperiods (often less than 30 min) and are generally population phenomena rather than intermediate responses o...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049300800104
更新日期：1993-04-01 00:00:00
abstract：:Activity patterns are the product of interactions between an internal circadian clock and direct responses to photic and nonphotic features of the environment that are said to "mask" the influence of that clock. Evolutionary transitions between nocturnality and diurnality involve changes in mechanisms underlying both ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409351672
更新日期：2010-02-01 00:00:00
abstract：:Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have desc...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730403251802
更新日期：2003-04-01 00:00:00
abstract：:Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420925573
更新日期：2020-08-01 00:00:00
abstract：:Two major approaches have been used to model circadian clocks. Qualitative modeling, used prior to the recent wealth of detailed molecular knowledge, makes general predictions but cannot provide detailed mechanistic insights. The more recent biophysical approach, on the other hand, incorporates the biochemical events ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730407301823
更新日期：2007-06-01 00:00:00
abstract：:The light preferences of fruit flies were tested by 2 different means. First, flies were allowed to choose between different illuminations, and their favorite resting, grooming, and feeding places were determined with an infrared-sensitive camera. Second, the activity levels of the animals during their main daily acti...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407306198
更新日期：2007-10-01 00:00:00
abstract：:The circadian rhythm of eclosion activity and its pacemaker were analyzed in a series of latitudinal races of Drosophila auraria ranging from 34.2 degrees to 42.9 degrees N in Japan. The phase of the rhythm (psi EL) to the daily photoperiod (PP) changes as daylength is increased, and the slope of psi EL (PP) changes w...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:The purpose of this study was to determine whether decreased day lengths affect reproduction or the immune system in inbred mice. Irrespective of a nocturnal pineal melatonin rise, the signal for day length information, body and testis weights were the same in various strains 8 weeks after transfer from long to short ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873002129002348
更新日期：2002-02-01 00:00:00
abstract：:A recent report that popliteal illumination shifted the circadian rhythms of body temperature and melatonin challenged the longstanding belief that light phase-shifting the circadian system in mammals is mediated only through the retina. The authors tested effects of popliteal illumination and illumination provided th...
journal_title：Journal of biological rhythms
pub_type： 临床试验,杂志文章
doi：10.1177/074873040001500307
更新日期：2000-06-01 00:00:00
abstract：:The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and daily feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood as those of light entrainment. To elucidate the first step of entrainment of the liver clock, we identified the circadian c...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730411405958
更新日期：2011-06-01 00:00:00
abstract：:The adjustment of hamsters to advanced light-dark (LD) cycles can be greatly accelerated by scheduling a single 3-hr bout of extra activity in a novel running wheel, starting about 7 hr before the time when the animals become active in the preceding LD cycle. The present experiments were designed to provide stronger e...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048900400305
更新日期：1989-10-01 00:00:00
abstract：:Previous research has demonstrated a clear link between late chronotype and depression. The vulnerability factors underpinning this link, however, are unclear. Here the relationship between two specific emotion regulation strategies, cognitive reappraisal and expressive suppression, and chronotype was investigated usi...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417709111
更新日期：2017-08-01 00:00:00
abstract：:Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocyt...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409332042
更新日期：2009-04-01 00:00:00
abstract：:We investigated the extent to which photoperiodic fluctuations synchronize annual thyroid and gonadal rhythmicity in edible dormice. The effects of different daylength manipulations (LD 4:20, LD 6:18, LD 18:6, LD 20:4) were examined during the two critical ascending and regressive phases of the annual plasma testoster...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049100600405
更新日期：1991-01-01 00:00:00
abstract：:A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420965291
更新日期：2020-12-01 00:00:00
abstract：:Most of the anatomical and molecular substrates of the system that encodes changes in photoperiod in the duration of melatonin secretion, and the receptor molecules that read this signal, have been shown to be conserved in monkeys and humans, and the functions of this system appear to be intact from the level of the r...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/074873001129002060
更新日期：2001-08-01 00:00:00
abstract：:Photoreception in the mammalian retina is not restricted to rods and cones but extends to a small number of intrinsically photosensitive retinal ganglion cells expressing the photopigment melanopsin. These mRGCs are especially important contributors to circadian entrainment, the pupil light reflex, and other so-called...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730411409719
更新日期：2011-08-01 00:00:00
abstract：:Access to electric light might have shifted the ancestral timing and duration of human sleep. To test this hypothesis, we studied two communities of the historically hunter-gatherer indigenous Toba/Qom in the Argentinean Chaco. These communities share the same ethnic and sociocultural background, but one has free acce...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730415590702
更新日期：2015-08-01 00:00:00
abstract：:The mammalian endogenous circadian clock, the suprachiasmatic nuclei, receives environmental inputs, namely the light-dark cycle, through photopigments located in the eye and from melanopsin-expressing retinal ganglion cells. The authors investigated the influence of light wavelength and intensity on the synchronizati...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730410368244
更新日期：2010-06-01 00:00:00
abstract：:DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405280195
更新日期：2005-10-01 00:00:00
abstract：:The retinohypothalamic tract (RHT), a monosynaptic retinal projection to the SCN, is the major path by which light entrains the circadian system to the external photoperiod. The circadian system of rodents effectively integrates or counts photons, and the magnitude of the rhythm phase response is proportional to the t...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405280458
更新日期：2005-12-01 00:00:00
abstract：:A physiologically based mathematical model of a putative sleep-wake regulatory network is used to investigate the transition from typical human sleep patterns to spontaneous internal desynchrony behavior observed under temporal isolation conditions. The model sleep-wake regulatory network describes the neurotransmitte...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730413504277
更新日期：2013-10-01 00:00:00
abstract：:The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk. When meals are supplied at a fixed time du...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873098128999880
更新日期：1998-02-01 00:00:00
abstract：:An understanding of the retinal mechanisms in mammalian photoentrainment will greatly facilitate optimization of the wavelength, intensity, and duration of phototherapeutic treatments designed to phase shift endogenous biological rhythms. A small population of widely dispersed retinal ganglion cells projecting to the ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730403018003005
更新日期：2003-06-01 00:00:00
abstract：:Drosophila littoralis is a latitudinally widespread European species of the Drosophila virilis group. The species has ample genetic variation in photoperiodism (adult diapause) and circadian rhythmicity (pupal eclosion rhythm), with adaptive latitudinal clines in both of them. The possible common genetic basis between...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405283418
更新日期：2006-02-01 00:00:00
abstract：:Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730404272907
更新日期：2005-04-01 00:00:00
abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406290317
更新日期：2006-08-01 00:00:00
