The circadian clock starts ticking at a developmentally early stage.


:Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embryonic stem cells. Nevertheless, upon their differentiation into neurons, circadian gene expression was observed. In the first steps along the pathway from ES cells to neurons, a neural precursor cell (NPC) line already showed robust circadian oscillations. Therefore, at a cellular level, the circadian clock likely begins at the very earliest stages of mammalian development.


J Biol Rhythms


Kowalska E,Moriggi E,Bauer C,Dibner C,Brown SA




Has Abstract


2010-12-01 00:00:00














  • Metabolic rate changes proportionally to circadian frequency in tau mutant Syrian hamsters.

    abstract::The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Oklejewicz M,Hut RA,Daan S,Loudon AS,Stirland AJ

    更新日期:1997-10-01 00:00:00

  • Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).

    abstract::Circadian rhythms are programmed by the suprachiasmatic nucleus (SCN), which relies on neuropeptide signaling to maintain daily timekeeping. Vasoactive intestinal polypeptide (VIP) is critical for SCN function, but the precise role of VIP neurons in SCN circuits is not fully established. To interrogate their contribut...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Joye DAM,Rohr KE,Keller D,Inda T,Telega A,Pancholi H,Carmona-Alcocer V,Evans JA

    更新日期:2020-08-01 00:00:00

  • Awakening to the behavioral analysis of sleep in Drosophila.

    abstract::Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share ma...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Shaw P

    更新日期:2003-02-01 00:00:00

  • Circadian Vision in Zebrafish: From Molecule to Cell and from Neural Network to Behavior.

    abstract::Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that contr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Li L

    更新日期:2019-10-01 00:00:00

  • Functional conservation of clock output signaling between flies and intertidal crabs.

    abstract::Intertidal species have both circadian and circatidal clocks. Although the behavioral evidence for these oscillators is more than 5 decades old, virtually nothing is known about their molecular clockwork. Pigment-dispersing hormones (PDHs) were originally described in crustaceans. Their insect homologs, pigment-disper...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Beckwith EJ,Lelito KR,Hsu YW,Medina BM,Shafer O,Ceriani MF,de la Iglesia HO

    更新日期:2011-12-01 00:00:00

  • Is social jetlag associated with an adverse endocrine, behavioral, and cardiovascular risk profile?

    abstract::Social jetlag represents the discrepancy between circadian and social clocks, which is measured as the difference in hours in midpoint of sleep between work days and free days. Previous studies have shown social jetlag to be associated with body mass index (BMI), glycated hemoglobin levels, heart rate, depressive symp...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rutters F,Lemmens SG,Adam TC,Bremmer MA,Elders PJ,Nijpels G,Dekker JM

    更新日期:2014-10-01 00:00:00

  • Gastrin-releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons.

    abstract::The mammalian circadian clock in the suprachiasmatic nucleus (SCN) drives and maintains 24-h physiological rhythms, the phases of which are set by the local environmental light-dark cycle. Gastrin-releasing peptide (GRP) communicates photic phase setting signals in the SCN by increasing neurophysiological activity of ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Gamble KL,Kudo T,Colwell CS,McMahon DG

    更新日期:2011-04-01 00:00:00

  • At least four distinct circadian regulatory mechanisms are required for all phases of rhythms in mRNA amount.

    abstract::Since the advent of techniques to investigate gene expression on a large scale, numerous circadian rhythms in mRNA amount have been reported. These rhythms generally differ in amplitude and phase. The authors investigated how far a parameter not regulated by the circadian clock can influence the phase of a rhythm in R...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Jacobshagen S,Kessler B,Rinehart CA

    更新日期:2008-12-01 00:00:00

  • Magnesium Regulates the Circadian Oscillator in Cyanobacteria.

    abstract::The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Jeong YM,Dias C,Diekman C,Brochon H,Kim P,Kaur M,Kim YS,Jang HI,Kim YI

    更新日期:2019-08-01 00:00:00

  • Rapid Jetlag Resetting of Behavioral, Physiological, and Molecular Rhythms in Proestrous Female Mice.

    abstract::A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Pilorz V,Kolms B,Oster H

    更新日期:2020-12-01 00:00:00

  • Photoperiodic and food signals control expression pattern of the clock gene, period, in the linden bug, Pyrrhocoris apterus.

    abstract::The temporal expression pattern of the circadian clock gene period was compared between heads of the linden bug, Pyrrhocoris apterus , kept under diapause-promoting short days (SD) and diapause-preventing long days (LD) using a real-time PCR quantification. Diapause or reproduction was programmed by photoperiod during...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Dolezel D,Sauman I,Kost'ál V,Hodkova M

    更新日期:2007-08-01 00:00:00

  • Food-deprivation-induced phase shifts in Sminthopsis macroura froggatti.

    abstract::Past research has shown that there is a circadian oscillator in laboratory rats that is entrained by restricted feeding schedules. However, in laboratory rats at least, the light-dark (LD) cycle is the dominant zeitgeber in the entrainment of wheel-running activity rhythms. Given that dasyurid marsupials are predomina...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Coleman GJ,O'Reilly HM,Armstrong SM

    更新日期:1989-04-01 00:00:00

  • Cry1-/- circadian rhythmicity depends on SCN intercellular coupling.

    abstract::In mammals, the suprachiasmatic nucleus (SCN) is the central pacemaker organizing circadian rhythms of behavior and physiology. At the cellular level, the mammalian clock consists of autoregulatory feedback loops involving a set of "clock genes," including the Cryptochrome (Cry) genes, Cry1 and Cry2. Experimental evid...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Evans JA,Pan H,Liu AC,Welsh DK

    更新日期:2012-12-01 00:00:00

  • A New Rhodopsin Influences Light-dependent Daily Activity Patterns of Fruit Flies.

    abstract::Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh70) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns duri...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kistenpfennig C,Grebler R,Ogueta M,Hermann-Luibl C,Schlichting M,Stanewsky R,Senthilan PR,Helfrich-Förster C

    更新日期:2017-10-01 00:00:00

  • Serotonin agonist quipazine induces photic-like phase shifts of the circadian activity rhythm and c-Fos expression in the rat suprachiasmatic nucleus.

    abstract::Nonphotic stimuli can reset and entrain circadian activity rhythms in hamsters and mice, and serotonin is thought to be involved in the phase-resetting effects of these stimuli. In the present study, the authors examined the effect of the serotonin agonist quipazine on circadian activity rhythms in three inbred strain...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kohler M,Kalkowski A,Wollnik F

    更新日期:1999-04-01 00:00:00

  • Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice.

    abstract::DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Noshiro M,Furukawa M,Honma S,Kawamoto T,Hamada T,Honma K,Kato Y

    更新日期:2005-10-01 00:00:00

  • Fbxl11 Is a Novel Negative Element of the Mammalian Circadian Clock.

    abstract::In mammals, molecular circadian rhythms are generated by autoregulatory transcriptional-translational feedback loops with PERIOD/CRYPTOCHROME containing complexes inhibiting the transcription of their own genes. Although the major circadian oscillator components seem to be identified, an increasing number of additiona...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Reischl S,Kramer A

    更新日期:2015-08-01 00:00:00

  • Unexpected c-fos gene expression in the suprachiasmatic nucleus of mice entrained to a skeleton photoperiod.

    abstract::Several authors have suggested that the transcriptional regulatory protein c-Fos might be part of the mechanism for photic entrainment of the circadian pacemaker in the suprachiasmatic nucleus (SCN) to environmental light:dark cycles. This hypothesis has been based on evidence gathered using single light pulses admini...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Schwartz WJ,Peters RV,Aronin N,Bennett MR

    更新日期:1996-03-01 00:00:00

  • Modeling interindividual differences in spontaneous internal desynchrony patterns.

    abstract::A physiologically based mathematical model of a putative sleep-wake regulatory network is used to investigate the transition from typical human sleep patterns to spontaneous internal desynchrony behavior observed under temporal isolation conditions. The model sleep-wake regulatory network describes the neurotransmitte...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Gleit RD,Diniz Behn CG,Booth V

    更新日期:2013-10-01 00:00:00

  • Destruction of serotonergic neurons in the median raphe nucleus blocks circadian rhythm phase shifts to triazolam but not to novel wheel access.

    abstract::Systematic treatment of hamsters with triazolam (TRZ) or novel wheel (NW) access will yield PRCs similar to those for neuropeptide Y. Both TRZ and NW access require an intact intergeniculate leaflet (IGL) to modulate circadian rhythm phase. It is commonly suggested that both stimulus types influence rhythm phase respo...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Meyer-Bernstein EL,Morin LP

    更新日期:1998-12-01 00:00:00

  • Is self-reported morbidity related to the circadian clock?

    abstract::Morningness and eveningness preference, an endogenous component of the circadian clock, is characterized by an interindividual difference in circadian phase and requires of humans a specific timing of behavior. The biological rhythms of morning and evening types are consequently phase shifted with fixed socioeconomic ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Taillard J,Philip P,Chastang JF,Diefenbach K,Bioulac B

    更新日期:2001-04-01 00:00:00

  • Saturation of enzyme kinetics in circadian clock models.

    abstract::From the mathematical study of simple models for circadian rhythm, the authors identified a clear effect of saturation in the enzyme kinetics on the promotion or suppression of a sustained oscillation. In the models, a clock gene (per gene) is transcribed to produce mRNAs, which are translated to produce proteins in t...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kurosawa G,Iwasa Y

    更新日期:2002-12-01 00:00:00

  • Circadian locomotor rhythms, but not photoperiodic responses, survive surgical isolation of the SCN in hamsters.

    abstract::Surgical isolation of the suprachiasmatic nuclei (SCN) within a hypothalamic island is reported to produce loss of circadian rhythmicity. The results have been interpreted to indicate that SCN efferents are necessary for the expression of circadian rhythms. It is not clear, however, whether the loss of circadian rhyth...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Hakim H,DeBernardo AP,Silver R

    更新日期:1991-07-01 00:00:00

  • Obesity Disrupts Rhythmic Clock Gene Expression in Maternal Adipose Tissue during Rat Pregnancy.

    abstract::Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock al...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Crew RC,Mark PJ,Waddell BJ

    更新日期:2018-06-01 00:00:00

  • Regulation of circadian photic responses by nitric oxide.

    abstract::A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Melo L,Golombek DA,Ralph MR

    更新日期:1997-08-01 00:00:00

  • Simulation of day-length encoding in the SCN: from single-cell to tissue-level organization.

    abstract::The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rohling J,Wolters L,Meijer JH

    更新日期:2006-08-01 00:00:00

  • p38 MAP kinase regulates circadian rhythms in Drosophila.

    abstract::The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mamma...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Vrailas-Mortimer AD,Ryan SM,Avey MJ,Mortimer NT,Dowse H,Sanyal S

    更新日期:2014-12-01 00:00:00

  • Casein Kinase 1 Underlies Temperature Compensation of Circadian Rhythms in Human Red Blood Cells.

    abstract::Temperature compensation and period determination by casein kinase 1 (CK1) are conserved features of eukaryotic circadian rhythms, whereas the clock gene transcription factors that facilitate daily gene expression rhythms differ between phylogenetic kingdoms. Human red blood cells (RBCs) exhibit temperature-compensate...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Beale AD,Kruchek E,Kitcatt SJ,Henslee EA,Parry JSW,Braun G,Jabr R,von Schantz M,O'Neill JS,Labeed FH

    更新日期:2019-04-01 00:00:00

  • Predicting regulation of the phosphorylation cycle of KaiC clock protein using mathematical analysis.

    abstract::Abstract The cyanobacterial clock protein KaiC regulates the circadian cycle by exhibiting rhythms in transcription, translation, and phosphorylation. KaiC phosphorylation persists in circadian cycling even under transcription-less conditions and was reconstituted in vitro by incubating KaiC, KaiA, and KaiB. This pres...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Takigawa-Imamura H,Mochizuki A

    更新日期:2006-10-01 00:00:00

  • Daily rhythms of Fos expression in hypothalamic targets of the suprachiasmatic nucleus in diurnal and nocturnal rodents.

    abstract::Little is known about the differences in the neural substrates of circadian rhythms that are responsible for the maintenance of differences between diurnal and nocturnal patterns of activity in mammals. In both groups of animals, the suprachiasmatic nucleus (SCN) functions as the principal circadian pacemaker, and sur...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Nunez AA,Bult A,McElhinny TL,Smale L

    更新日期:1999-08-01 00:00:00