Fungal sepsis: optimizing antifungal therapy in the critical care setting.

Abstract:

:Invasive fungal infections (IFI) and fungal sepsis in the intensive care unit are increasing and are associated with considerable morbidity and mortality. In this setting, IFI are predominantly caused by Candida species. Outcomes continue to be suboptimal; however, there are a few key clinician modifiable factors. PK-PD studies with the approved antifungal agents have provided guidance on the dosing strategy that predicts improved outcome. In addition, time to therapy is a critical element. Therefore early recognition through improved risk factor analysis and diagnostics will be key developments. Source control for infected devices and endophthalmitis must be considered.

journal_name

Crit Care Clin

journal_title

Critical care clinics

authors

Lepak A,Andes D

doi

10.1016/j.ccc.2010.11.001

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

123-47

issue

1

eissn

0749-0704

issn

1557-8232

pii

S0749-0704(10)00098-9

journal_volume

27

pub_type

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