Abstract:
PURPOSE:To compare tear protein markers between normal subjects and patients with dry eye (DE) and high and low lymphotoxin-alpha (LT-α) levels. DESIGN:Prospective cross-sectional study. METHODS:Patients with DE were divided into low (≤700 pg/mL) and high (>700 pg/mL) LT-α groups. Twelve protein markers were measured by microsphere-based immunoassay and ocular surface parameters were determined in right eyes (33 high LT-α DE, 27 low LT-α DE, and 20 control eyes) and left eyes (21 high LT-α DE, 39 low LT-α DE, and 20 control eyes). RESULTS:In both eyes, tumor necrosis factor-α (TNF-α), interleukin (IL)-10, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-17A, and IL-12/23 p40 levels in high LT-α DE were significantly higher (P < .01) than in low LT-α DE. Significant correlations identified in high LT-α DE were: Standard Patient Evaluation Eye Dryness with IL-10 (R = 0.43, P = .013), IL-1β (R = 0.48, P = .005), and IL-12/23 p40 (R = 0.50, P = .003), IL-12/23 p40 with ocular surface disease index (R = 0.35, P = .049), and epidermal growth factor with corneal fluorescein staining score (R = -0.36, P = .038). Significant correlations in low LT-α DE were: Standard Patient Evaluation Eye Dryness with IL-10 (R = -0.39, P = .046), TNF-α (R = -0.39, P = .047), and IL-17A (R = -0.48, P = .013), ocular surface disease index with TNF-α (R = -0.47, P = .017) and IL-17A (R = -0.46, P = .018), and IL-6 with tear breakup time (R = -0.40, P = .044). Lastly, IL-1Ra levels significantly increased in DE patients, positively correlated with temporal conjunctival hyperemia index, and negatively correlated with Schirmer I test (P < .05). CONCLUSIONS:Our study identified tear IL-1Ra level as a potential biomarker to replace the Schirmer I test. Multiple tear protein marker levels increased in high LT-α DE, indicating that high LT-α DE might have a different pathogenesis.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Chen H,Chen H,Liang L,Zhong Y,Liang Y,Yu Y,Huang S,Lu Xdoi
10.1016/j.ajo.2020.03.013subject
Has Abstractpub_date
2020-09-01 00:00:00pages
198-211eissn
0002-9394issn
1879-1891pii
S0002-9394(20)30113-6journal_volume
217pub_type
杂志文章abstract:PURPOSE:To assess the visual outcome of inferior limited macular translocation in eyes selected based on the distance from the fovea to the inferior edge of the subfoveal choroidal neovascularization. DESIGN:Interventional case series. METHODS:We performed inferior limited macular translocation in 12 consecutive eyes...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01413-7
更新日期:2002-06-01 00:00:00
abstract:PURPOSE:To evaluate the use of disk diameter as an indicator in the identification of glaucomatous optic neuropathy. METHODS:We evaluated all available stereofundus photographs for 1,040 right eyes obtained in the Reykjavik Eye Study. Horizontal and vertical disk diameters were determined in a masked manner by a glauc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01928-1
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:To compare the efficacy of intraoperative scleral application with subconjunctival injection of mitomycin C (MMC) in trabeculectomy. DESIGN:Prospective, randomized, interventional study. METHODS:This study took place in a single clinical practice in an academic setting. Patients had medically uncontrolled gla...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2020.07.002
更新日期:2020-12-01 00:00:00
abstract::A 21-year-old white woman had an apparently benign fibrous histiocytoma at the corneoscleral limbus. By histopathologic and ultrastructural studies, the tumor consisted of lipid-containing histiocytes and fibrocytic cells arranged in a storiform configuration with a collagenous interstitium. After an excision, the les...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90391-8
更新日期:1975-10-01 00:00:00
abstract::The extent of visual function loss from nuclear cataractous change can be estimated by observing the extinction of blue light compared to white light as a function of sagittal lens depth in standard slit lamps. Apparent extinction (loss of transmissivity) of 50% or more of the depth of the lens in blue light of maxima...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(81)90057-x
更新日期:1981-05-01 00:00:00
abstract::We conducted a two-part study to determine whether any positive association between the use of allopurinol and the development of cataracts could be demonstrated. Study 1 included 251 Boston-area patients hospitalized for cataract and 753 matched controls. Two cataract patients were regular allopurinol users as compar...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(84)90328-3
更新日期:1984-09-15 00:00:00
abstract:PURPOSE:To evaluate the effect of contact lens (CL) wear and visual display terminal (VDT) work on the ocular surface and tear functions. DESIGN:Prospective case-control study. METHODS:Sixty-nine CL wearers (45 women and 24 men; mean age, 35.2 ± 7.3 years), and 102 age- and sex-matched non-CL wearers were enrolled in...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.05.025
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To evaluate high-order aberrations (HOA) induced by the anterior corneal surface after deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK). DESIGN:Prospective, randomized clinical trial. METHODS:Twenty-eight eyes of 25 patients with corneal edema resulting from Fuchs dystrophy unde...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2008.12.039
更新日期:2009-06-01 00:00:00
abstract::A countrywide prevalence survey of 9,508 children was conducted in El Salvador to determine the prevalence of anterior-segment abnormalities and magnitude of clinical vitamin A deficiency. Thirty-six children had corneal opacities, 56% of them secondary to trauma. Such traumatic corneal opacities were 19 times more fr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90337-2
更新日期:1975-12-01 00:00:00
abstract:PURPOSE:To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. DESIGN:Multicenter, prospective randomized clinical trial. METHODS:setting: Sixteen international clinical centers. STUDY POPULATION:Two hundred seventy-six subjects aged 18-85 years with previous intraocul...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2015.11.023
更新日期:2016-03-01 00:00:00
abstract::In the elderly patient with a massive vitreous hemorrhage in one eye and senile macular choroidal degenerative changes in the fellow eye, a hemorrhagic disciform detachment causing this massive vitreous hemorrhage must be considered in the differential diagnosis. Ultrasonography selectively combined with radioactive p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75023-8
更新日期:1980-10-01 00:00:00
abstract::We successfully treated six patients with culture-proven acute bacterial endophthalmitis by a combination of emergency pars plana vitrectomy and the instillation of intravitreal antibiotics. All six patients regained satisfactory vision. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76806-0
更新日期:1978-08-01 00:00:00
abstract::We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76658-9
更新日期:1978-01-01 00:00:00
abstract:PURPOSE:To describe a case of severe dry eye syndrome in a child. METHODS:Observational case report. The authors describe a 10-year-old male with severe dry eyes who was profoundly disabled by pain and photophobia despite aggressive conventional therapy. Lacrimal gland histology was consistent with the primary Sjögren...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01182-5
更新日期:2001-12-01 00:00:00
abstract:PURPOSE:To critically evaluate the potential impact of the coronavirus disease (COVID-19) pandemic on global ophthalmology and VISION 2020. DESIGN:Perspective supplemented with epidemiologic insights from available online databases. METHODS:We extracted data from the Global Vision Database (2017) and Global Burden of...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.11.016
更新日期:2020-12-09 00:00:00
abstract::By means of an immunofluorescent technique, we found factors promoting blood coagulation and platelet adhesion in the intima of retinal vessels. These factors coexisted with other agents causing the opposite process, fibrin dissolution. The components of this vascular hemostatic balance are possibly involved in the th...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90867-3
更新日期:1975-07-01 00:00:00
abstract::Six patients with retinal detachment associated with the acute retinal necrosis syndrome were treated by the combination of vitrectomy, gas injection, and laser photocoagulation. The retinas were successfully reattached in each patient with one operation. Five of the patients achieved a visual acuity of 20/200 or bett...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(88)90878-1
更新日期:1988-10-15 00:00:00
abstract:PURPOSE:To report a case of migration of liquid silicone into the upper eyelid. DESIGN:Interventional case report. METHODS:A 32-year-old woman had an injection of liquid silicone into the subcutaneous tissue of the forehead. She developed a cystic mass in the upper eyelid 2 days postinjection. An excisional biopsy wa...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00465-3
更新日期:2003-11-01 00:00:00
abstract::A patient with X-chromosome-linked recessive Norrie's disease, characterized by retinal falciform fold, retinal detachment, repeated vitreous hemorrhage, and retrolental membrane formation, was observed from age 6 weeks. The patient showed the clinical progression from these early retinal and vitreous changes to the m...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75079-2
更新日期:1980-07-01 00:00:00
abstract::We studied a new method for photographing cataractous lens opacaities by retroillumination. The slit-lamp microscope was modified with an adaptor to eliminate the specular reflection from the corneal surface. We construcated two kinds of adaptors for the Zeiss and Goldmann-type slit-lamp microscopes. The cataractous l...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74852-4
更新日期:1980-08-01 00:00:00
abstract:PURPOSE:We investigated whether opsin mislocalization occurs in photoreceptors in a female carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the retinitis pigmentosa GTPase regulator gene (RPGR). DESIGN:Histologic findings in autopsy eyes from a carrier were compared with those from a normal female...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.03.061
更新日期:2006-09-01 00:00:00
abstract::Subretinal neovascularization was demonstrated in a subhuman primate eye (Macaca speciosa) one year after the internal carotid injection of yeast-phase Histoplasma capsulatum. In this animal model of ocular histoplasmosis, initial injection of viable H. capsulatum results in the development of self-limiting acute mult...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(85)90790-1
更新日期:1985-08-15 00:00:00
abstract:PURPOSE:To characterize outcomes for patients who develop full-thickness macular holes after pars plana vitrectomy. METHODS:We retrospectively analyzed data for 47 consecutive patients (47 eyes) who developed full-thickness macular holes after initial pars plana vitrectomy for a variety of indications. All patients un...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.01.030
更新日期:2008-06-01 00:00:00
abstract::A brother and sister, born to consanguineous parents, had pigmentary retinopathy in a pericentral distribution. The retinopathy was noted in infancy when the siblings were examined for strabismus. The optic disks, maculae, and retinal vessels were normal. There was mild reduction in amplitude of both scotopic and phot...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(88)90584-3
更新日期:1988-11-15 00:00:00
abstract:PURPOSE:We report a case of a submacular surgery complicated by a choroidal neovascular membrane at the retinotomy site. METHOD:The patient underwent submacular surgery for the removal of an idiopathic choroidal neovascular membrane. RESULT:Three weeks after surgery, the patient developed a choroidal neovascular memb...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70499-4
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:Diseases that involve retinal or choroidal vascular endothelial cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies, and noninfectious posterior uveitis. Proteins differentially expressed by these endothelial cell populations are potential drug targets. We ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.03.020
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:Although the course of vitreomacular traction syndrome is necessary to treat patients or to establish the value of the surgical technique, little information is available about its course. In this study, we ascertained the natural history of vitreomacular traction syndrome. METHODS:We retrospectively studied 5...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73813-9
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:To describe the presentation and subsequent management of a case of severe gonococcal keratitis in a young man. DESIGN:Case report. METHODS:A young man presented with severe gonococcal keratitis. Topical and systemic antibiotics were given with no improvement, and progressive corneal melting was noted. Deep l...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.04.014
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To analyze the indocyanine green angiographic findings of drusen in the early stages of age-related macular degeneration. METHODS:Sixty-nine eyes of 53 consecutive patients with drusen but without exudative complications of age-related macular degeneration were studied. Drusen were classified into four groups:...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70826-8
更新日期:1997-09-01 00:00:00
abstract::Conjunctivodacryocystorhinostomy with a Jones tube is an accepted procedure for the treatment of epiphora resulting from obstructed canaliculi. Because of our clinical impression that a high rate of functional success after surgery is associated with a lower rate of patient satisfaction, we analyzed the results and pa...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70070-4
更新日期:1994-05-15 00:00:00