Abstract:
BACKGROUND:Depressive disorders are common among cancer patients. Ketamine can quickly relieve depression, and its subcutaneous administration appears to be as effective as and probably safer than its standard intravenous administration. Herein, we report a case verifying the antidepressant effect of a subcutaneous esketamine formulation. CASE PRESENTATION:A 65-year-old male with metastatic abdominal tumor reported sadness, weight loss, fatigue, hopelessness, insomnia, inattention, and reduced motivation. His scores on the visual analogical scale for pain and Montgomery-Asberg depression rating scale were 8/10 and 30/60, respectively. POSSIBLE COURSES OF ACTION:Monoaminergic antidepressants are effective, but their response is slow for end-of-life care. FORMULATION OF A PLAN:Esketamine was preferred because it possibly contributes to pain relief. It can repeatedly be infused intravenously, but was subcutaneously administered twice a week for safety reasons. OUTCOME:The patient showed continuous mood improvement, achieving depression remission on day 7. Pain relief was observed but without stability. His vital signs remained stable, and he remained calm, without major complaints. LESSONS FROM THE CASE:Repeated subcutaneous esketamine injections are possibly safe and effective in pain and depression relief in palliative care cancer patients. VIEW ON RESEARCH PROBLEMS, OBJECTIVES, OR QUESTIONS GENERATED BY THE CASE:Placebo-controlled studies with similar cases are needed to establish efficacy and safety.
journal_name
Palliat Medjournal_title
Palliative medicineauthors
Barbosa MG,Delfino RS,Sarin LM,Jackowski APdoi
10.1177/0269216320910351subject
Has Abstractpub_date
2020-06-01 00:00:00pages
822-825issue
6eissn
0269-2163issn
1477-030Xjournal_volume
34pub_type
杂志文章abstract::This paper is a secondary observation of a larger pilot study. The Assessing Caregivers for Team Intervention via Video Encounters intervention project enabled caregiver participation in hospice interdisciplinary team meetings. This paper used the team observation scale to assess the impact of caregiver involvement on...
journal_title:Palliative medicine
pub_type: 杂志文章,多中心研究
doi:10.1177/0269216309352066
更新日期:2010-03-01 00:00:00
abstract::This study looked at the efficacy of drug treatment in managing death rattle in a 30-bedded specialist palliative care unit. The study was conducted in two phases. In the first, patients received hyoscine hydrobromide as the antimuscarinic; glycopyrrolate was used in the second phase. The patients in the two phases we...
journal_title:Palliative medicine
pub_type: 临床试验,杂志文章
doi:10.1191/026921601678320313
更新日期:2001-07-01 00:00:00
abstract::The most commonly encountered clinical conditions presenting with cognitive failure (CF) are delirium, dementia and amnestic disorders. Of these, delirium is probably the most prevalent in palliative care, and it is potentially reversible. Thus, improvement in diagnostics seems warranted. The objectives of this review...
journal_title:Palliative medicine
pub_type: 杂志文章,评审
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journal_title:Palliative medicine
pub_type: 杂志文章
doi:10.1177/0269216316628780
更新日期:2016-09-01 00:00:00
abstract::The purpose of this study was to further validate a novel instrument to measure satisfaction with end-of-life care, called the Canadian Health Care Evaluation Project (CANHELP) questionnaire. Data were collected by a cross-sectional survey of patients who had advanced, life-limiting illnesses and their family caregive...
journal_title:Palliative medicine
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更新日期:2010-10-01 00:00:00
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journal_title:Palliative medicine
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doi:10.1177/0269216312445188
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journal_title:Palliative medicine
pub_type: 杂志文章,评审
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journal_title:Palliative medicine
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更新日期:2012-03-01 00:00:00
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journal_title:Palliative medicine
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journal_title:Palliative medicine
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journal_title:Palliative medicine
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journal_title:Palliative medicine
pub_type: 杂志文章,评审
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更新日期:2011-07-01 00:00:00
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journal_title:Palliative medicine
pub_type: 杂志文章,评审
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journal_title:Palliative medicine
pub_type: 杂志文章,meta分析,评审
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journal_title:Palliative medicine
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journal_title:Palliative medicine
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journal_title:Palliative medicine
pub_type: 杂志文章,多中心研究
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journal_title:Palliative medicine
pub_type: 杂志文章,评审
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更新日期:1997-07-01 00:00:00
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