Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review.

Abstract:

:The European Association for Palliative Care recommendation for starting morphine for cancer pain is dose titration with immediate release (IR) oral morphine given every 4 h with additionally doses for breakthrough pain. As part of a EU 6th framework programme to revise the guidelines we review the evidence regarding starting treatment and dose titration of opioids in adult patients with moderate to severe cancer pain. Relevant papers were identified though a systematic search in Medline for papers published until the end of 2009. We identified 15 relevant papers. Thirteen papers were descriptive papers reporting the results from starting treatment with oral morphine (six studies), starting treatment with intravenous morphine (two studies) and starting treatment with transdermal fentanyl (four studies). All treatment strategies resulted in acceptable pain control and were well tolerated. Two randomized controlled trials were identified. One study compared starting opioid treatment with intravenous morphine versus IR oral morphine and one study compared IR oral morphine versus sustained release oral morphine.

journal_name

Palliat Med

journal_title

Palliative medicine

authors

Klepstad P,Kaasa S,Borchgrevink PC

doi

10.1177/0269216310386280

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

424-30

issue

5

eissn

0269-2163

issn

1477-030X

pii

25/5/424

journal_volume

25

pub_type

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