Vitamin D deficiency and its association with fatigue and quality of life in advanced cancer patients under palliative care: A cross-sectional study.


BACKGROUND:A normal vitamin D status is required for bones and muscles to maintain their function and structure, but it also contributes to the functional integrity of other multiple physiologic systems in the body. AIM:To assess the relationship of Vitamin D deficiency with health-related quality-of-life issues, fatigue, and physical functioning in advanced cancer patients. DESIGN:This is a cross-sectional study. PATIENTS/SETTINGS:Adults under palliative care, having a locally advanced or metastatic or inoperable solid cancer. RESULTS:Among 30 patients in palliative care with advanced solid cancer, 90% were vitamin D deficient. Serum Vitamin D concentration was positively correlated with patient-reported absence of fatigue (s = 0.49), and physical and functional well-being (s = 0.44 and s = 0.41, respectively, p < 0.01). Fatigue was the symptom with the highest median impact on their lives and was the only one associated with serum vitamin D (p = 0.031), with lower fatigue in patients with vitamin D concentrations in the third tertile. There was no evidence of a direct association between health-related quality of life and vitamin D status. CONCLUSION:The 90% frequency of advanced cancer patients with vitamin D deficiency, together with the positive correlation of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient's quality of life.


Palliat Med


Palliative medicine


Martínez-Alonso M,Dusso A,Ariza G,Nabal M




Has Abstract


2016-01-01 00:00:00














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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Ugalde A,Mathers S,Hennessy Anderson N,Hudson P,Orellana L,Gluyas C

    更新日期:2018-04-01 00:00:00

  • Exploring factors and caregiver outcomes associated with feelings of preparedness for caregiving in family caregivers in palliative care: a correlational, cross-sectional study.

    abstract:BACKGROUND:Family caregivers in palliative care often report feeling insufficiently prepared to handle the caregiver role. Preparedness has been confirmed as a variable that may actually protect family caregiver well-being. Preparedness refers to how ready family caregivers perceive they are for the tasks and demands i...

    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Henriksson A,Årestedt K

    更新日期:2013-07-01 00:00:00

  • Implementation of a pilot telehealth programme in community palliative care: A qualitative study of clinicians' perspectives.

    abstract:BACKGROUND:Telehealth technologies are an emerging resource opening up the possibility of greater support if they have utility for patients, carers and clinicians. They may also help to meet health systems' imperatives for improved service delivery within current budgets. Clinicians' experiences and attitudes play a ke...

    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Collier A,Morgan DD,Swetenham K,To TH,Currow DC,Tieman JJ

    更新日期:2016-04-01 00:00:00

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    journal_title:Palliative medicine

    pub_type: 杂志文章,评审


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    更新日期:1997-09-01 00:00:00

  • Presenting symptoms and signs in children referred for palliative care in Malawi.

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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Lavy V

    更新日期:2007-06-01 00:00:00

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    journal_title:Palliative medicine

    pub_type: 杂志文章,评审


    authors: Hjermstad M,Loge JH,Kaasa S

    更新日期:2004-09-01 00:00:00

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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Morgan DD,Tieman JJ,Allingham SF,Ekström MP,Connolly A,Currow DC

    更新日期:2019-06-01 00:00:00

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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Vale-Taylor P

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    journal_title:Palliative medicine

    pub_type: 杂志文章


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    journal_title:Palliative medicine

    pub_type: 杂志文章,随机对照试验


    authors: Mitchell GK,Senior HE,Rhee JJ,Ware RS,Young S,Teo PC,Murray S,Boyd K,Clayton JM

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    journal_title:Palliative medicine

    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:Palliative medicine

    pub_type: 杂志文章


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    journal_title:Palliative medicine

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    journal_title:Palliative medicine

    pub_type: 杂志文章


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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Maloney C,Lyons KD,Li Z,Hegel M,Ahles TA,Bakitas M

    更新日期:2013-04-01 00:00:00

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    journal_title:Palliative medicine

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    更新日期:2000-07-01 00:00:00

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    abstract::Comprehensive palliative care programs are often implemented on a community level, and to evaluate such interventions, randomization by cluster (community) may be the only feasible method. In trials randomizing individual subjects, the importance of proper concealment has been stressed. In cluster randomized trials, h...

    journal_title:Palliative medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jordhøy MS,Fayers PM,Ahlner-Elmqvist M,Kaasa S

    更新日期:2002-01-01 00:00:00

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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Michiels E,Deschepper R,Van Der Kelen G,Bernheim JL,Mortier F,Vander Stichele R,Deliens L

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    journal_title:Palliative medicine

    pub_type: 杂志文章,评审


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    更新日期:2008-03-01 00:00:00

  • Impact of home-based, patient-centered support for people with advanced illness in an open health system: A retrospective claims analysis of health expenditures, utilization, and quality of care at end of life.

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    journal_title:Palliative medicine

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    authors: Best M,Butow P,Olver I

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    journal_title:Palliative medicine

    pub_type: 杂志文章,评审


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    journal_title:Palliative medicine

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    更新日期:1998-01-01 00:00:00

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  • The relationship between opioid use and laxative use in terminally ill cancer patients.

    abstract::The frequency of the use of laxatives, and the relationship between doses of laxatives and of opioid analgesia, were determined by a prospective study of 498 hospice inpatients with advanced cancer. Laxatives were required by 87% of patients taking oral strong opioids, 74% of those on weak opioids and 64% of those not...

    journal_title:Palliative medicine

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    journal_title:Palliative medicine

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    journal_title:Palliative medicine

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    journal_title:Palliative medicine

    pub_type: 杂志文章


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    更新日期:1999-07-01 00:00:00

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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Paes P,Wee B

    更新日期:2008-06-01 00:00:00

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    journal_title:Palliative medicine

    pub_type: 杂志文章


    authors: Ribeiro AF,Martins Pereira S,Gomes B,Nunes R

    更新日期:2019-12-01 00:00:00