Progressive multifocal leukoencephalopathy and palliative care: a report of three cases and review of the literature.

Abstract:

:Progressive multifocal leukoencephalopathy (PML) is a rare but usually fatal demyelinating disease of the central nervous system in patients who are immunocompromised. It is characterized by rapid neurological deterioration associated with progressive white matter changes on imaging and is confirmed by isolation of the causative virus in the cerebrospinal fluid or brain tissue. Currently there are no effective treatments for PML and outcomes remain poor even after reversal of the immunocompromised state. This case series describes three patients with different underlying pathologies and varying presentations who were all diagnosed with PML and referred to a palliative care service.

journal_name

Palliat Med

journal_title

Palliative medicine

authors

Cotton PJ,Le B

doi

10.1177/0269216312450932

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

286-8

issue

3

eissn

0269-2163

issn

1477-030X

pii

0269216312450932

journal_volume

27

pub_type

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