Vitamin D and Sleep Regulation: Is there a Role for Vitamin D?

abstract：:Diabetic retinopathy remains the most common microvascular complication suffered by diabetic patients and is the leading cause of registerable blindness in the working population of developed countries. The clinicopathological lesions of diabetic retinopathy have been well characterised and although a multitude of pat...

journal_title：Current pharmaceutical design

authors： Stitt AW,Frizzell N,Thorpe SR

更新日期：2004-01-01 00:00:00

abstract：:The involvement of the central nervous system (CNS) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients and the less understood aspect of the disease. Its recognition and treatment continue to represent a major diagnostic and therapeutic challenge. Due to the lack of co...

journal_title：Current pharmaceutical design

authors： Sanna G,Bertolaccini ML,Khamashta MA

更新日期：2008-01-01 00:00:00

abstract：:Rapid increase in the emergence and spread of microbes resistant to conventionally used antibiotics has become a major threat to global health care. Antimicrobial peptides (AMPs) are considered as a potential source of novel antibiotics because of their numerous advantages such as broad-spectrum activity, lower tenden...

journal_title：Current pharmaceutical design

authors： Lohan S,Bisht GS

更新日期：2013-01-01 00:00:00

abstract：:In recent years several new drugs (oxcarbazepine, lamotrigine, topiramate, gabapentin, zonisamide, tiagabine, fosphenytoin, vigabatrin and felbamate) have been added to the therapeutic armamentarium against epilepsy. Some of these represent structural modifications of pre-existing compounds, others were developed with...

journal_title：Current pharmaceutical design

authors： Gatti G,Bonomi I,Jannuzzi G,Perucca E

更新日期：2000-05-01 00:00:00

abstract：:There is an increased use of oral anticoagulants for the prevention of venous and arterial thrombosis. Vitamin-K antagonists have been used for decades as the main oral anticoagulants but they have the draback a complex therapeutic management, slow onset of action and by a different oral intake caused by dietary vitam...

journal_title：Current pharmaceutical design

authors： Lamperti M,Khozenko A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：:Emerging evidence has shown that microRNAs (miRNAs) can act as oncogenes in the initiation and progression of leukemia and lymphoma. Aberrant expression of oncogenic miRNAs, including miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223 promotes leukemogenesis through increasing the leukemic...

journal_title：Current pharmaceutical design

authors： Pan Y,Meng M,Zhang G,Han H,Zhou Q

更新日期：2014-01-01 00:00:00

abstract：:Cytokines are known to play a key role in regulation of gastric functions. Interferon-alpha (IFN-α) has been published to impair gastric motility. Aims of this study were to clarify effect of IFN-α on gastric acid secretion (GAS) and determine role of nitric oxide (NO) in the process. Both subcutaneous (1000, 10000, 1...

journal_title：Current pharmaceutical design

authors： Czimmer J,Király Á,Szabó IL,Mózsik G,Sütő G

更新日期：2013-01-01 00:00:00

abstract：:Guidelines for the treatment of hypertension allow a wide range of choices to the physicians; however some differences are present about the preferred drugs to start treatment. The most important aim remains an adequate decrease of blood pressure, something not perfectly obtained in the general population, but some cl...

journal_title：Current pharmaceutical design

authors： Pende A,Dallegri F

更新日期：2012-01-01 00:00:00

abstract：:The substantial morbidity and mortality associated with invasive fungal infections constitute undisputed tokens of their severity. The continued expansion of susceptible population groups (such as immunocompromised individuals, patients undergoing extensive surgery, and those hospitalized with serious underlying disea...

journal_title：Current pharmaceutical design

authors： Anastassopoulou CG,Fuchs BB,Mylonakis E

更新日期：2011-01-01 00:00:00

abstract：:Depression is one of the leading causes of disability in the world. Current pharmaceutical treatment for depression remains unsatisfactory due to its limited therapeutic efficacy and undesirable side effects. There is increasing interest in looking for alternative strategies from diet for the treatment of depressive d...

journal_title：Current pharmaceutical design

authors： Wang X,Zhao F,Wang X,Niu Y,Niu L,Wang C

更新日期：2018-01-01 00:00:00

abstract：:Over the last two decades, SPECT (single photon emission computed tomography) and especially PET (positron emission tomography) have proven increasingly effective imaging modalities in the study of human psychopharmacology. Abusing populations can be studied at multiple times after abstinence begins, to give informati...

journal_title：Current pharmaceutical design

authors： Gatley SJ,Volkow ND,Wang GJ,Fowler JS,Logan J,Ding YS,Gerasimov M

更新日期：2005-01-01 00:00:00

abstract：:A small but increasing number of gene expression based biomarkers are becoming available for routine clinical use, principally in oncology and transplantation. These underscore the potential of gene expression arrays and RNA sequencing for biomarker development, but this potential has not yet been fully realized and m...

journal_title：Current pharmaceutical design

authors： Flint SM,McKinney EF,Lyons PA,Smith KG

更新日期：2015-01-01 00:00:00

abstract：:Genetic variation in the receptors and other intracellular targets that mediate the pharmacodynamic effects of drugs can affect therapeutic outcomes. However, at present greater knowledge is available concerning the extent of gene variation in drug metabolizing enzymes that determine drug pharmacokinetics and, in turn...

journal_title：Current pharmaceutical design

authors： Crettol S,Petrovic N,Murray M

更新日期：2010-01-01 00:00:00

abstract：:Cell therapy has been proposed to treat patients with end-stage heart failure. However, it has been suggested that the significant mechanical forces in an often ischaemic, inflamed, biochemically hostile environment may cause poor cell survival and retention. It is hypothesised that tissue engineering techniques could...

journal_title：Current pharmaceutical design

authors： Rao C,Barratt H,Prodromakis T,Terracciano CM

更新日期：2014-01-01 00:00:00

abstract：Background:Capsinoids (CSN), the novel non-pungent capsaicin analogs have been reported to promote metabolic health and exercise tolerance. However, the effect of CSN on fat oxidation and changes in skeletal muscle glycogen levels during post-exercise recovery has not been investigated in humans. Purpose:We examined t...

journal_title：Current pharmaceutical design

authors： Liao SF,Korivi M,Tsao JP,Huang CC,Chang CC,Cheng IS

更新日期：2020-08-23 00:00:00

abstract：:We have gained considerable insight and understanding about the etiology, embryogenesis of the myocardium, genetic background, diagnosis and outcome of left ventricular non-compaction (LVNC) over the last 2 decades. LVNC has a distinct morphological appearance with a thickened, two-layered myocardium consisting of an ...

journal_title：Current pharmaceutical design

authors： Ganame J

更新日期：2015-01-01 00:00:00

abstract：:Periodontal diseases are common inflammatory conditions of the supporting apparatus of the teeth which lead to early tooth loss. This review discusses the evidence for a role of reactive oxygen species in inducing periodontal tissue damage and focuses on recent evidence showing increased local and systemic alterations...

journal_title：Current pharmaceutical design

authors： Nibali L,Donos N

更新日期：2013-01-01 00:00:00

abstract：:The introduction of highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus (HIV) infection has significantly improved the life expectancy of HIV positive patients. Hepatitis C virus (HCV) co-infection is common in HIV infected patients and is now a significant cause of morbidity and mortality. ...

journal_title：Current pharmaceutical design

authors： Fabris P,Barnes E,Tositti G,Giordani MT,Grasso A,De Lalla F

更新日期：2004-01-01 00:00:00

abstract：:The derangement of the cardiac energy substrate metabolism plays a key role in the pathogenesis of heart failure. The utilization of non-carbohydrate substrates, such as fatty acids, is the predominant metabolic pathway in the normal heart, because this provides the highest energy yield per molecule of substrate metab...

journal_title：Current pharmaceutical design

authors： Nagoshi T,Yoshimura M,Rosano GM,Lopaschuk GD,Mochizuki S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The failing heart is characterized by a depleted metabolic energy reserve and the upregulation of several molecular mechanisms leading to cardiac hypertrophy, inflammation, fibrosis, angiogenesis, and apoptosis. Dietary or non-dietary supplementation of vitamins could potentially benefit energy balance. OBJ...

journal_title：Current pharmaceutical design

authors： Georgiopoulos G,Chrysohoou C,Vogiatzi G,Magkas N,Bournelis I,Bampali S,Gruson D,Tousoulis D

更新日期：2017-01-01 00:00:00

abstract：:Over the past decade, Lymphocyte Function-Associated Antigen-1 (LFA-1, alphaLbeta2, CD11a/CD18) has emerged as an attractive therapeutic target for the treatment of multiple inflammatory diseases. Its established role in the trafficking and activation of leukocytes coupled with the recent elucidation of the global con...

journal_title：Current pharmaceutical design

authors： Giblin PA,Lemieux RM

更新日期：2006-01-01 00:00:00

abstract：:Although acute renal graft rejection rate has declined in the last years, and because an adequate therapy can improve graft outcome, its therapy remains as one of the most significant challenges for pharmacists and physicians taking care of transplant patients. Due to the lack of evidence highlighted by the available ...

journal_title：Current pharmaceutical design

authors： Rodrigo E,Chedid MF,Segundo DS,Millán JCRS,López-Hoyos M

更新日期：2020-01-01 00:00:00

abstract：:Androgen receptor (AR) is a steroid hormone receptor that is activated by endogenous androgens, mainly testosterone and 5alpha-dihydrotestosterone (5alpha-DHT). AR is also an important drug target, and AR antagonists (antiandrogens) have been widely used for prostate cancer therapy. Antiandrogens currently available o...

journal_title：Current pharmaceutical design

authors： Gao W

更新日期：2010-01-01 00:00:00

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：:Withdrawn by the publisher. ...

journal_title：Current pharmaceutical design

authors：

更新日期：2018-11-13 00:00:00

abstract：:Mediation of antinociception via opioid receptors located in the periphery is a viable strategy to produce analgesia without the occurrence of side effects associated with stimulation of opioid receptors located in the central nervous system. Peripheral opioid receptors are particularly important in inflammatory pain ...

journal_title：Current pharmaceutical design

authors： DeHaven-Hudkins DL,Dolle RE

更新日期：2004-01-01 00:00:00

abstract：:Kv7.x channels are a family of six transmembrane domain, single pore-loop, voltage-gated K(+) channels. Five members of the family have been identified to date, including the cardiac channel Kv7.1 (formerly known as KvLQT1) and four neuronal Kv7.x channels, Kv7.2-5. Heteromeric channels containing Kv7.3 and either Kv7...

journal_title：Current pharmaceutical design

authors： Wickenden AD,McNaughton-Smith G

更新日期：2009-01-01 00:00:00

abstract：:Neurodegenerative disorders are one of the most critical public health concerns of our times. Regrettably, therapeutic interventions currently available have shown only partial benefits to patients affected by one of these disorders. Although the important advances made during the last decades, several questions regar...

journal_title：Current pharmaceutical design

authors： Bastias-Candia S,Garrido A N,Zolezzi JM,Inestrosa NC

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Spice and spice-derived compounds have been identified and explored for their health benefits since centuries. One of the spice long pepper has been traditionally used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, malaria, viral hepatitis, respirato...

journal_title：Current pharmaceutical design

authors： Prasad S,Tyagi AK

更新日期：2016-01-01 00:00:00

abstract：:Locomotion is one of the most complex motor behaviors. Locomotor patterns change during early life, reflecting development of numerous peripheral and hierarchically organized central structures. Among them, the spinal cord is of particular interest since it houses the central pattern generator (CPG) for locomotion. Th...

journal_title：Current pharmaceutical design

authors： Brumley MR,Guertin PA,Taccola G

更新日期：2017-01-01 00:00:00