Withdrawn: Nanotechnology as an emerging pathway for cancer therapy and diagnosis.

Abstract:

:Withdrawn by the publisher.

journal_name

Curr Pharm Des

authors

subject

Has Abstract

pub_date

2018-11-13 00:00:00

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-94520

pub_type

杂志文章
  • Analgesics in Pregnancy: An Update on Use, Safety and Pharmacokinetic Changes in Drug Disposition.

    abstract:BACKGROUND:Although medications should only be prescribed in pregnancy if benefits to the mother outweigh the risk to the fetus, drug use in pregnancy especially prescribed and over-the-counter analgesics, is very common. OBJECTIVE:The objective of this review is to present an update on known changes in analgesic disp...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666170825123754

    authors: Price HR,Collier AC

    更新日期:2017-01-01 00:00:00

  • Anti-TNF therapy for Crohn's disease.

    abstract::Although the cause of Crohn's disease remains unknown considerable progress has been made in recent years to unravel the pathogenesis of the inflammatory processes seen in chronic idiopathic inflammatory bowel diseases (IBD). Th-1 lymphocytes seem to orchestrate the inflammation through the production of pro-inflammat...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612033391982

    authors: D'Haens G

    更新日期:2003-01-01 00:00:00

  • Role of copper in prion diseases: deleterious or beneficial?

    abstract::Prion diseases are fatal neurodegenerative disorders associated with conformational conversion of the cellular prion protein (PrP(C)) into an isoform designated PrP(Sc). The pathogenic mechanism that links this conformational distortion with the development of prion diseases is unknown. PrP(C) is a GPI-anchored cell s...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206777698873

    authors: Varela-Nallar L,González A,Inestrosa NC

    更新日期:2006-01-01 00:00:00

  • Strategies to Avoid TAVI-related Acute Kidney Injury.

    abstract::Acute kidney injury (AKI) is relatively common in patients undergoing transcatheter aortic valve implantation (TAVI) and has been associated with increased mortality and worse outcomes. The administration of iodinated contrast media in an elderly population with increased rates of chronic kidney injury and heart failu...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666151208120522

    authors: Kampaktsis PN,Feldman DN,Charitakis K

    更新日期:2016-01-01 00:00:00

  • Oncogenic microRNAs in the genesis of leukemia and lymphoma.

    abstract::Emerging evidence has shown that microRNAs (miRNAs) can act as oncogenes in the initiation and progression of leukemia and lymphoma. Aberrant expression of oncogenic miRNAs, including miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223 promotes leukemogenesis through increasing the leukemic...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612820666140128211724

    authors: Pan Y,Meng M,Zhang G,Han H,Zhou Q

    更新日期:2014-01-01 00:00:00

  • Abnormal bodily experiences may be a marker of early schizophrenia?

    abstract::The purpose of this study is to answer the following question: What are the typical features of abnormal bodily experiences (ABEs) in persons affected by acute first-episode schizophrenia? Our overall objective is to contribute to enhance early diagnosis of schizophrenia, and providing supplementary diagnostic criteri...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161212799316181

    authors: Stanghellini G,Ballerini M,Fusar Poli P,Cutting J

    更新日期:2012-01-01 00:00:00

  • Food addiction and neuroimaging.

    abstract::Obesity has become a serious epidemic and one of the leading global health problems. However, much of the current debate has been fractious, and etiologies of obesity have been attributed to eating behavior (i.e. fast food consumption), personality, depression, addiction or genetics. One of the interesting new hypothe...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161211795656855

    authors: Zhang Y,von Deneen KM,Tian J,Gold MS,Liu Y

    更新日期:2011-01-01 00:00:00

  • Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents.

    abstract:PURPOSE:The emerging evidence has recently shown an evident dependence between recently identified salusin peptides and atherosclerosis, and their important roles as endogenous modulators of atherogenesis. It was reported that the development of atherosclerosis could also be affected by endogenous salusin- β overproduc...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612824666180607124531

    authors: Kołakowska U,Kuroczycka-Saniutycz E,Olański W,Wasilewska A

    更新日期:2018-01-01 00:00:00

  • The role of mast cells in the structural alterations of the airways as a potential mechanism in the pathogenesis of severe asthma.

    abstract::Mast cells, traditionally regarded as effector cells of the immune system, have more recently been demonstrated to be key figures in initiating, developing and sustaining complex pathophysiological processes underlying asthma and other allergic diseases. Asthma is characterised by airway inflammation alongside a distu...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211795428975

    authors: Carter RJ,Bradding P

    更新日期:2011-01-01 00:00:00

  • Sodium-glucose Cotransporter 2 Inhibitors (SGLT2i): Their Role in Cardiometabolic Risk Management.

    abstract:BACKGROUND:Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel category of oral antidiabetic drugs that inhibit renal glucose reabsorption and increase renal glucose excretion, thus lowering plasma glucose levels. This unique mechanism of SGLT2i action is insulin independent, thus improving glycemic control ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666170113152742

    authors: Katsiki N,Mikhailidis DP,Theodorakis MJ

    更新日期:2017-01-01 00:00:00

  • Hypersensitivity reactions to iodinated contrast media.

    abstract::Adverse reactions after iodinate contrast media (ICM) administration have been observed, which can be classified as immediate (i.e., occurring within one hour after administration) and delayed or non-immediate (i.e., occurring more than one hour after administration). Even though the incidence of ICM adverse reactions...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206778193999

    authors: Guéant-Rodriguez RM,Romano A,Barbaud A,Brockow K,Guéant JL

    更新日期:2006-01-01 00:00:00

  • Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules.

    abstract::Regeneration of bone requires the coordinated processes of angiogenesis and osteogenesis. These repair mechanisms are closely linked through both direct cell-cell contact and indirect paracrine signaling among osteoblasts, endothelial cells, and other cell types. The vasculature provides a source of nutrients, oxygen,...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811319190007

    authors: Segar CE,Ogle ME,Botchwey EA

    更新日期:2013-01-01 00:00:00

  • Modulation of gene transcription by natural products--a viable anticancer strategy.

    abstract::Drug design based on the structure of specific enzymes playing a role in carcinogenesis, e.g. tyrosine kinases, has been successful at identifying novel effective anticancer drugs. In contrast, no success has been achieved in drug design attempts, in which transcription factors or DNA-transcription factor complexes in...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161207781757097

    authors: D'Incalci M,Brunelli D,Marangon E,Simone M,Tavecchio M,Gescher A,Mantovani R

    更新日期:2007-01-01 00:00:00

  • The Pictet-Spengler Reaction Still on Stage.

    abstract::Today, in spite of being older than a century (born in 1911), the Pictet-Spengler two component reaction (PS-2CR) is still one of the most popular reactions, not only for the synthesis of tetrahydroisoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), or more complex structures containing these two privileged moieti...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666151231100247

    authors: Ingallina C,D'Acquarica I,Delle Monache G,Ghirga F,Quaglio D,Ghirga P,Berardozzi S,Markovic V,Botta B

    更新日期:2016-01-01 00:00:00

  • Extraction of Essential Oils from Medicinal Plants and their Utilization as Food Antioxidants.

    abstract:BACKGROUND:The use of essential oils is receiving increasing attention worldwide, as these oils are good sources of several bioactive compounds. Nowadays essential oils are preferred over synthetic preservatives thanks to their antioxidant and antimicrobial properties. Several studies highlight the beneficial effect of...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612826666200121092018

    authors: Ferrentino G,Morozova K,Horn C,Scampicchio M

    更新日期:2020-01-01 00:00:00

  • Can mycobacterial genomics generate novel targets as speed-breakers against the race for drug resistance.

    abstract::The rise of multi-drug resistant and extensively drug resistant M. tuberculosis around the world poses a great threat to human health, and necessitates development of new, effective and inexpensive anti-tubercular agents. The availability of knowledge on molecular biology of M. tuberculosis infection coupled with whol...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612819666131118165427

    authors: Chauhan RS,Chanumolu SK,Rout C,Shrivastava R

    更新日期:2014-01-01 00:00:00

  • Role of dendritic cell-derived cytokines in immune regulation.

    abstract::Over the last several years, it has become increasingly clear that dendritic cells (DC) are not only critical for the initiation of T cell immunity, but these cells also determine the course of the subsequent immune response (i.e. tolerance vs. immunity, Th1 vs. Th2). However, the mechanisms by which DC can influence ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612013397627

    authors: Wan Y,Bramson J

    更新日期:2001-07-01 00:00:00

  • Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva.

    abstract::Transforming growth factor-β family members, which include TGF-βs, activins and bone morphogenetic proteins (BMPs), play important roles in development and maintaining tissue homeostasis. The extracellular TGF-β family members signal across the plasmamembrane by activating type I and type II serine/threonine kinase re...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161212802430495

    authors: de Gorter DJ,Jankipersadsing V,Ten Dijke P

    更新日期:2012-01-01 00:00:00

  • Pharmacophore identification and quantitative bioactivity prediction using the electron-conformational method.

    abstract::A review of the Electron-Conformational (EC) method of pharmacophore (Pha) identification and quantitative bioactivity prediction in drug design and toxicology is presented, which includes the latest advances and improvements of the method as a whole and details of its realization with illustration of results. In the ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612033454586

    authors: Bersuker IB

    更新日期:2003-01-01 00:00:00

  • Serotonin 5-HT1A Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs.

    abstract::Schizophrenia is characterised by positive, negative, cognitive, depressive and anxiety symptoms. Over the last decades a number of novel treatment strategies with better clinical efficacy and scope, but with lower side-effect profiles have been developed. These have significantly improved the management and prognosis...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150605105215

    authors: McCreary AC,Newman-Tancredi A

    更新日期:2015-01-01 00:00:00

  • Leptin and the OB-receptor as anti-obesity target: recent in silico advances in the comprehension of the protein-protein interaction and rational drug design of anti- obesity lead compounds.

    abstract::The OB-receptor or leptin receptor (LR) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream. Under normal circumstances, circulating leptin levels are proportionate to the fat body mass. Sensing of elevated leptin levels ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113196660743

    authors: Tutone M,Lauria A,Almerico AM

    更新日期:2014-01-01 00:00:00

  • Regulatory T cells: major players in the tumor microenvironment.

    abstract::Over the last years a number of reports have described elevated numbers of regulatory T (Treg) cells inside of tumors, in close proximity of the tumor, draining lymph nodes and also in peripheral blood of patients with solid tumors and hematologic malignancies. There is increasing evidence that Treg cells can migrate ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161209788453211

    authors: Beyer M,Schultze JL

    更新日期:2009-01-01 00:00:00

  • Radiolabeled compounds in diagnosis of infectious and inflammatory disease.

    abstract::Nuclear medicine offers powerful noninvasive techniques for visualization of infectious and inflammatory disorders using whole body imaging enabling the determination of both localization and number of inflammatory foci. A wide variety of approaches depicting the different stages of the inflammatory response have been...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612043383539

    authors: Bleeker-Rovers CP,Boerman OC,Rennen HJ,Corstens FH,Oyen WJ

    更新日期:2004-01-01 00:00:00

  • Subcutaneous Immunoglobulins: A Promising Alternative for Immunomodulation?

    abstract::Cumulative recent evidence from clinical trials, observational studies and case reports has shown that subcutaneous administration of immunoglobulin (SCIg) exerts similar immunomodulatory capacity than intravenous immunoglobulin (IVIg) in autoimmune neurological diseases. Besides the beneficial clinical effects, the p...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666160831103806

    authors: Sanchez-Ramon S,Corbi AL,Fidalgo AG,Dominguez-Soto A

    更新日期:2016-01-01 00:00:00

  • NLRP3 Inhibitors as Potential Therapeutic Agents for Treatment of Inflammatory Bowel Disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) is a group of intestinal disorders characterised by chronic relapsing inflammation of the small intestine and colon. IBD manifests as either ulcerative colitis or Crohn's disease and increases the risk of developing colorectal cancer. METHODS:Here, we have reviewed current t...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666170201162414

    authors: Perera AP,Kunde D,Eri R

    更新日期:2017-01-01 00:00:00

  • Pharmacogenetics of thiopurines in inflammatory bowel disease.

    abstract::Thiopurines are widely used in the treatment of inflammatory bowel disease (IBD). However, in clinical practice azathioprine (AZA) or 6-mercaptopurine (6-MP) are not effective in one-third of patients and up to one-fifth of patients discontinue thiopurine therapy due to adverse reactions. The observed interindividual ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210790112773

    authors: Derijks LJ,Wong DR

    更新日期:2010-01-01 00:00:00

  • LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics.

    abstract::Over the past decade, Lymphocyte Function-Associated Antigen-1 (LFA-1, alphaLbeta2, CD11a/CD18) has emerged as an attractive therapeutic target for the treatment of multiple inflammatory diseases. Its established role in the trafficking and activation of leukocytes coupled with the recent elucidation of the global con...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206777947731

    authors: Giblin PA,Lemieux RM

    更新日期:2006-01-01 00:00:00

  • Comparative genomics for the investigation of autoimmune diseases.

    abstract::The complete DNA sequence of the human genome and of several related mammals are now available, due to the investments of enormous resources and advances in sequencing technology. Novel technologies have been developed to compare multiple genomes with each other, thus specifying regions of sequence similarity among ma...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206778559795

    authors: Möller S,Zettl UK,Serrano-Fernández P,Goertsches R

    更新日期:2006-01-01 00:00:00

  • Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus.

    abstract::New biopharmaceutical molecules, potentially able to provide more personalized and effective treatments, are being identified through the advent of advanced synthetic biology strategies, sophisticated chemical synthesis approaches, and new analytical methods to assess biological potency. However, translation of many o...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666151216151420

    authors: Munsell EV,Ross NL,Sullivan MO

    更新日期:2016-01-01 00:00:00

  • Recent Updates in the Computer Aided Drug Design Strategies for the Discovery of Agonists and Antagonists of Adenosine Receptors.

    abstract:: ...

    journal_title:Current pharmaceutical design

    pub_type: 社论

    doi:10.2174/1381612825999190515120510

    authors: Deb PK

    更新日期:2019-01-01 00:00:00