The Contribution of Transcriptomics to Biomarker Development in Systemic Vasculitis and SLE.

Abstract:

:A small but increasing number of gene expression based biomarkers are becoming available for routine clinical use, principally in oncology and transplantation. These underscore the potential of gene expression arrays and RNA sequencing for biomarker development, but this potential has not yet been fully realized and most candidates do not progress beyond the initial report. The first part of this review examines the process of gene expression- based biomarker development, highlighting how systematic biases and confounding can significantly skew study outcomes. Adequate validation in an independent cohort remains the single best means of protecting against these concerns. The second part considers gene-expression based biomarkers in Systemic Lupus Erythematosus (SLE) and systemic vasculitis. The type 1 interferon inducible gene signature remains by far the most studied in autoimmune rheumatic disease. While initially presented as an objective, blood-based biomarker of active SLE, subsequent research has shown that it is not specific to SLE and that its association with disease activity is considerably more nuanced than first thought. Nonetheless, it is currently under evaluation in ongoing trials of anti-interferon therapy. Other candidate markers of note include a prognostic CD8+ T-cell gene signature validated in SLE and ANCA-associated vasculitis, and a disease activity biomarker for SLE derived from modules of tightly correlated genes.

journal_name

Curr Pharm Des

authors

Flint SM,McKinney EF,Lyons PA,Smith KG

doi

10.2174/1381612821666150313130256

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

2225-35

issue

17

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-65913

journal_volume

21

pub_type

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