Therapy of chronic hepatitis C virus infection in HIV co-infected people.

Abstract:

:The introduction of highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus (HIV) infection has significantly improved the life expectancy of HIV positive patients. Hepatitis C virus (HCV) co-infection is common in HIV infected patients and is now a significant cause of morbidity and mortality. Optimal management and treatment of HCV in HIV infected patients is therefore essential. Interferon-alpha (IFN-alpha) and ribavirin is the mainstay of treatment for HCV infection in HIV infected people. The sustained virological response rate (SVR) with combination therapy is lower than that commonly observed in HCV mono-infected patients. This is, at least in part, due to the very high treatment drop out rates. Ribavirin in combination with HAART is associated with particular side effects such as mitochondrial toxicity. Therefore, vigilant monitoring of patients during therapy, in specialist centers is essential. Pegylated interferon (PEG-IFN) plus ribavirin is particularly promising as it is easier to administer and will probably become the treatment of choice for co-infected patients. A SVR is associated with genotype 2 and 3, in addition to a high CD4+ cell count and a low HCV load prior to therapy. The progression of HCV related liver disease in HIV positive patients is faster than in subjects with HCV infection alone. As a result, there is an increasing incidence of cirrhosis and end-stage liver disease in co-infected patients. Liver transplantation is being evaluated in many centers. To date the experiences are very limited but encouraging in term of survival rate.

journal_name

Curr Pharm Des

authors

Fabris P,Barnes E,Tositti G,Giordani MT,Grasso A,De Lalla F

doi

10.2174/1381612043384286

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

2111-22

issue

17

eissn

1381-6128

issn

1873-4286

journal_volume

10

pub_type

杂志文章,评审
  • Herpes simplex viruses in antiviral drug discovery.

    abstract::Since the 1950's, herpes simplex viruses (HSV) have played prominent roles in the development of antivirals. The first efficacious antivirals, as well as the first safe for systemic use, were developed against HSV. It was only in 1995 when the first antiviral against a target not validated first with HSV was approved ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206776361174

    authors: Schang LM

    更新日期:2006-01-01 00:00:00

  • The oxido-reductase activity of the apoptosis inducing factor: a promising pharmacological tool?

    abstract::The apoptosis inducing factor (AIF) was first discovered as a caspase-independent apoptosis effector that promoted cell death upon release from the mitochondria (triggered by pro-apoptotic stimuli) and relocalization into the nucleus, where it promotes chromatin condensation and DNA fragmentation. AIF is a mammalian m...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811319140012

    authors: Ferreira P,Villanueva R,Cabon L,Susín SA,Medina M

    更新日期:2013-01-01 00:00:00

  • Periodontitis and redox status: a review.

    abstract::Periodontal diseases are common inflammatory conditions of the supporting apparatus of the teeth which lead to early tooth loss. This review discusses the evidence for a role of reactive oxygen species in inducing periodontal tissue damage and focuses on recent evidence showing increased local and systemic alterations...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811319150003

    authors: Nibali L,Donos N

    更新日期:2013-01-01 00:00:00

  • The role of polyunsaturated fatty acids (PUFA) in the treatment of dyslipidemias.

    abstract::Polyunsaturated fatty acids (PUFA) are a family of lipids including some subgroups identified by the position of the last double bond in their structure. PUFA n-3 include alpha linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), while PUFA n-6 include linoleic acid (LA) and arachidonic a...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161209789909773

    authors: Zuliani G,Galvani M,Leitersdorf E,Volpato S,Cavalieri M,Fellin R

    更新日期:2009-01-01 00:00:00

  • Coronary Microvascular and Cardiac Dysfunction Due to Homocysteine Pathometabolism; A Complex Therapeutic Design.

    abstract::In various metabolic diseases, both the coronary circulation and cardiac metabolism are altered. Here we summarize the effects of a condition called hyperhomocysteinemia (HHcy) - which can develop due to genetic and/or environmental causes - on the function of coronary microvessels and heart. This metabolic disease is...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612824666180625125450

    authors: Koller A,Szenasi A,Dornyei G,Kovacs N,Lelbach A,Kovacs I

    更新日期:2018-01-01 00:00:00

  • Human papillomavirus DNA and E6/E7 mRNA testing as triage in liquid-based cytology samples from primary screening.

    abstract::We estimated the frequency of detection of different human papillomavirus (HPV) types in women with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) cytology in a population-based primary screening programme. 247 liquid-based cytology (LBC) samples with A...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:

    authors: Andersson S,Mints M,Weiderpass E,Johansson B

    更新日期:2013-01-01 00:00:00

  • Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis.

    abstract::Apoptosis is a regulated process leading to cell death, which is implicated both in normal development and in various pathologies including heart failure, stroke and neurodegenerative diseases. Caspase-3, a key enzyme of the apoptotic pathway, is considered as a major target for the treatment of abnormal cell death. M...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211795049679

    authors: Seaborn T,Masmoudi-Kouli O,Fournier A,Vaudry H,Vaudry D

    更新日期:2011-01-01 00:00:00

  • CFTR inhibitors.

    abstract::The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated Cl- channel whose major function is to facilitate epithelial fluid secretion. Loss-of-function mutations in CFTR cause the genetic disease cystic fibrosis. CFTR is required for transepithelial fluid transport in certain secretor...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990321

    authors: Verkman AS,Synder D,Tradtrantip L,Thiagarajah JR,Anderson MO

    更新日期:2013-01-01 00:00:00

  • When ubiquitin meets NF-κB: a trove for anti-cancer drug development.

    abstract::During the last two decades, the studies on ubiquitination in regulating transcription factor NF-κB activation have elucidated the expanding role of ubiquitination in modulating cellular events by non-proteolytic mechanisms, as well as by proteasomal degradation. The significance of ubiquitination has also been recogn...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811319180010

    authors: Wu ZH,Shi Y

    更新日期:2013-01-01 00:00:00

  • 3D Printing in Pharmaceuticals: Regulatory Perspective.

    abstract:BACKGROUND:The last few decades have witnessed enormous advancements in the field of Pharmaceutical drug, design and delivery. One of the recent developments is the advent of 3DP technology. It has earlier been successfully employed in fields like aerospace, architecture, tissue engineering, biomedical research, medica...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666181130163027

    authors: Mirza MA,Iqbal Z

    更新日期:2018-01-01 00:00:00

  • TNF(alpha) modulation of visceral and spinal sensory processing.

    abstract::The cytokine tumor necrosis factor(alpha) (TNF(alpha)) is associated with a constellation of physiological and behavioral characteristics that follow in response to infection such as fever, fatigue, listlessness, loss of appetite, malaise, and tactile hypersensitivity. These responses are examples of central nervous s...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612053507828

    authors: Hermann GE,Holmes GM,Rogers RC

    更新日期:2005-01-01 00:00:00

  • Development of novel cardiovascular therapeutics from small regulatory RNA molecules--an outline of key requirements.

    abstract::Understanding of the roles of RNAs within the cell has changed and expanded dramatically during the past few years. Based on fundamentally new insights it is now increasingly possible to employ RNAs as highly valuable tools in molecular biology and medicine. At present, the most important therapeutic strategies are ba...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210791792813

    authors: Poller W,Fechner H

    更新日期:2010-01-01 00:00:00

  • The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders.

    abstract::Multiple molecular, cellular, structural and functional changes occur in the brain during aging. Neural cells may respond to these changes adaptively by employing multiple mechanisms in order to maintain the integrity of nerve cell circuits and to facilitate responses to environmental demands. Otherwise, they may succ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210790883741

    authors: Lanni C,Stanga S,Racchi M,Govoni S

    更新日期:2010-01-01 00:00:00

  • Cellular protection and therapeutic potential of tocotrienols.

    abstract::Tocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211796957436

    authors: Catalgol B,Batirel S,Ozer NK

    更新日期:2011-01-01 00:00:00

  • The importance of reendothelialization after arterial injury.

    abstract::Atherosclerosis is still the principal cause of morbidity and mortality in Western countries and although a significant progress has been made in the understanding of its pathophysiology, the determinants of atherosclerotic plaque instability are still poorly understood. The endothelium plays a pivotal role for the de...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161207780831239

    authors: Versari D,Lerman LO,Lerman A

    更新日期:2007-01-01 00:00:00

  • An Overview on Various Approaches and Recent Patents on Buccal Drug Delivery Systems.

    abstract:BACKGROUND:Buccal delivery is an alluring course of organization for fundamental medication conveyance and it leads direct access to the systemic flow through the interior jugular vein sidesteps drugs from the hepatic first-pass digestion gives high bioavailability. OBJECTIVE:This article aims at buccal medication con...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200614182013

    authors: Targhotra M,Chauhan MK

    更新日期:2020-01-01 00:00:00

  • Recent Advances in Nutrition for the Treatment of Depressive Disorder.

    abstract::Depression is one of the leading causes of disability in the world. Current pharmaceutical treatment for depression remains unsatisfactory due to its limited therapeutic efficacy and undesirable side effects. There is increasing interest in looking for alternative strategies from diet for the treatment of depressive d...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612824666180803113106

    authors: Wang X,Zhao F,Wang X,Niu Y,Niu L,Wang C

    更新日期:2018-01-01 00:00:00

  • Edible Mushrooms: Novel Medicinal Agents to Combat Metabolic Syndrome and Associated Diseases.

    abstract::Metabolic syndrome is an aggregation of conditions and associated with an increased risk of developing diabetes, obesity and cardiovascular diseases (CVD). Edible mushrooms are widely consumed in many countries and are valuable components of the diet because of their attractive taste, aroma, and nutritional value. Med...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200831151316

    authors: Tung YT,Pan CH,Chien YW,Huang HY

    更新日期:2020-01-01 00:00:00

  • The role of blood-brain barrier transporters in pathophysiology and pharmacotherapy of stroke.

    abstract::Cerebral ischemia is one of the major causes of disability worldwide. In cerebral ischemic stroke, occlusion of a major cerebral artery by an embolus or local thrombosis can result in transient or permanent reduction of cerebral blood flow to a portion of the brain, resulting in deprivation of glucose and oxygen. Sinc...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990465

    authors: Shah K,Abbruscato T

    更新日期:2014-01-01 00:00:00

  • Fibrate-associated adverse effects beyond muscle and liver toxicity.

    abstract::Fibrate derivatives have a 40-year history in the management of dyslipidemia. Although this class of drugs is generally well tolerated, several safety issues have arisen from their use. In the present article we review the literature describing side effects associated with the use of fibrates except for those that are...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208783885362

    authors: Florentin M,Liberopoulos EN,Mikhailidis DP,Elisaf MS

    更新日期:2008-01-01 00:00:00

  • Writers and Erasers of Histone Lysine methylation with Clinically Applied Modulators: Promising Target for Cancer Therapy.

    abstract::Histone lysine methylation can be modified by various writers and erasers. Different from other epigenetic modifications, mono-, di, and tri- methylation distinctly modulate chromatin structure and thereby contribute to the regulation of DNA-based nuclear processes such as transcription, replication and repair on thei...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666160715125417

    authors: Zheng YC,Ma JL,Liu Y,Liu HM

    更新日期:2016-01-01 00:00:00

  • Lipid-based Nanocarriers for Cancer and Tumor Treatment.

    abstract::Cancer and tumor have been major reasons for numerous deaths in this century across the world. Many strategies have been designed to treat, diagnose, or prevent cancer. The success of chemotherapy largely depends on drug targeting. The advent of nanotechnology has vastly improved drug delivery for targeting and diagno...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200720235752

    authors: Ansari MT,Ramlan TA,Jamaluddin NN,Zamri N,Salfi R,Khan A,Sami F,Majeed S,Hasnain MS

    更新日期:2020-01-01 00:00:00

  • Sulfated Polysaccharides from Macroalgae for Bone Tissue Regeneration.

    abstract:BACKGROUND:Utilization of macroalgae has gained much attention in the field of pharmaceuticals, nutraceuticals, food and bioenergy. Macroalgae has been widely consumed in Asian countries as food from ancient days and proved that it has potential bioactive compounds which are responsible for its nutritional properties. ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666190425161630

    authors: Venkatesan J,Anil S,Rao S,Bhatnagar I,Kim SK

    更新日期:2019-01-01 00:00:00

  • Metal/Metal Oxide Nanoparticles: Toxicity, Applications, and Future Prospects.

    abstract::The ever-growing resistance of pathogens to antibiotics and crop disease due to pest has triggered severe health concerns in recent years. Consequently, there is a need of powerful and protective materials for the eradication of diseases. Metal/metal oxide nanoparticles (M/MO NPs) are powerful agents due to their ther...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666191111091326

    authors: Chaudhary RG,Bhusari GS,Tiple AD,Rai AR,Somkuvar SR,Potbhare AK,Lambat TL,Ingle PP,Abdala AA

    更新日期:2019-01-01 00:00:00

  • Carbonic anhydrase inhibition/activation: trip of a scientist around the world in the search of novel chemotypes and drug targets.

    abstract::Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze CO(2) hydration to bicarbonate and protons. Five genetically distinct classes are known, which represent an excellent example of convergent evolution. Inhibition of α-CAs from vertebrates, including humans, with sulfonamides was exploited clinical...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210793429797

    authors: Supuran CT

    更新日期:2010-01-01 00:00:00

  • State of the art and perspectives in food allergy (part II): therapy.

    abstract::Currently management of food allergy is mainly based on absolute avoidance of the offending food(s) and the use of rescue medication. However, the risk of severe or life-threatening reactions due to inadvertent exposure, nutritional imbalance and social isolation raises the demand of disease-modifying treatments. The ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990045

    authors: Sabato V,Faber M,Van Gasse A,Hagendorens MM,Leysen J,Bridts CH,De Clerck LS,Ebo DG

    更新日期:2014-01-01 00:00:00

  • Unmasking the Many Faces of Giloy (Tinospora cordifolia L.): A fresh look on its phytochemical and medicinal properties.

    abstract:BACKGROUND:Plants have been used to treat health disorders and prevent diseases since antiquity in all civilizations including the Indian and Chinse civilizations. Giloy (Tinospora cordifolia L.) is one of the most important medicinal plants in Indian folk medicine and is commonly known as the "Heart-leaved Moonseed" o...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200625111530

    authors: Verma DK,Goyal K,Kumar P,El-Shazly M

    更新日期:2020-06-25 00:00:00

  • Acetylation control of cancer cell metabolism.

    abstract::Lysine acetylation plays an essential role in metabolism. Five individual studies have identified that a large number of cellular proteins are potentially acetylated. Notably, almost every enzyme involved in central metabolic pathways such as glycolysis, the TCA cycle, fat acid metabolism, urea cycle and glycogen meta...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/13816128113199990487

    authors: Lin R,Zhou X,Huang W,Zhao D,Lv L,Xiong Y,Guan KL,Lei QY

    更新日期:2014-01-01 00:00:00

  • Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of aging.

    abstract::An integrative synthesis of concepts and an explosion of experimental and epidemiological findings allow new insights as to how the interactions of genetic, environmental, dietary, cultural (social, psychological, economic) factors can influence the aging and diseases of aging processes. Although the net effect of the...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208786264106

    authors: Trosko JE

    更新日期:2008-01-01 00:00:00

  • Prodrugs in genetic chemoradiotherapy.

    abstract::Improvements in the radiotherapeutic management of solid tumors through the concurrent use of gene therapy is a realistic possibility. Of the broad array of candidate genes that have been evaluated, those encoding prodrug-activating enzymes are particularly appealing since they directly complement ongoing clinical che...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612033454117

    authors: Patterson AV,Saunders MP,Greco O

    更新日期:2003-01-01 00:00:00