Vitamins in Heart Failure: Friend or Enemy?

abstract：:The concept that the gut microbiota plays a major role in the development of pouchitis in ulcerative colitis patients after restorative proctocolectomy with ileal pouch-anal anastomosis, is widely accepted and supported by a widespread use of some antibiotics (metronidazole and/or ciprofloxacin, rifaximin) to treat th...

journal_title：Current pharmaceutical design

authors： Guslandi M

更新日期：2014-01-01 00:00:00

abstract：:The targeting of drugs to skeletal muscle is an emerging area of research. Driven by the need for new therapies to treat a range of muscle-associated diseases, these strategies aim to provide improved drug exposure at the site of action in skeletal muscle with reduced concentration in other tissues where unwanted side...

journal_title：Current pharmaceutical design

authors： Ebner DC,Bialek P,El-Kattan AF,Ambler CM,Tu M

更新日期：2015-01-01 00:00:00

abstract：:Runx2/Cbfa/AML3 is a member of the runt homology domain family of transcription factors, essential for osteoblast differentiation and bone formation. Defining the molecular mechanisms by which Runx2 can function as a master regulatory gene for activating the program of osteoblastogenesis has provided novel insights fo...

journal_title：Current pharmaceutical design

authors： Lian JB,Stein GS

更新日期：2003-01-01 00:00:00

abstract：:Oxidative and nitrosative stress triggers DNA strand breakage, which then activates the nuclear enzyme poly(ADP-ribose) polymerase (PARP). One of the key triggers of DNA single strand breakage in pathophysiological conditions is peroxynitrite, a reactive species produced from the reaction of nitric oxide and superoxid...

journal_title：Current pharmaceutical design

authors： Gero D,Szabó C

更新日期：2006-01-01 00:00:00

abstract：:Donkey's milk is the best substitute of human milk for its content in lactose, proteins, minerals, and omega-3 fatty acids. Here, we have evaluated the effects of colostrum and milk from donkeys (Martina Franca breed) on the function of human peripheral blood mononuclear cells (PBMCs) at different intervals from lacta...

journal_title：Current pharmaceutical design

authors： Tafaro A,Magrone T,Jirillo F,Martemucci G,D'Alessandro AG,Amati L,Jirillo E

更新日期：2007-01-01 00:00:00

abstract：:Management of hypertension has evolved steadily through 25 years of major clinical trials results modifying both the definition of hypertension and clinical management strategies. Trials experience in heart failure is much less extensive given the far smaller therapeutic market and traditionally often followed on the ...

journal_title：Current pharmaceutical design

authors： MacFadyen RJ,Lip GY,Davis R

更新日期：2003-01-01 00:00:00

abstract：:Human arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) are polymorphic phase II xenobiotic-metabolising enzymes (XME) that acetylate arylamine compounds. They therefore play an important role in the detoxication and/or metabolic activation of certain therapeutic drugs, occupational chemicals and carcinogens. Alt...

journal_title：Current pharmaceutical design

authors： Rodrigues-Lima F,Dupret JM

更新日期：2004-01-01 00:00:00

abstract：:Diabetes is an important metabolic disease affecting many organs and systems in the body. The nervous system is one of the body systems affected by diabetes and neuropathic complications are troublesome in diabetic patients with many consequences. As diabetes has deleterious influences almost on bodily systems, an int...

journal_title：Current pharmaceutical design

authors： Öztürk Y,Öztürk N

更新日期：2019-01-01 00:00:00

abstract：:Mass spectrometry imaging (MSI) can uniquely detect thousands of compounds allowing both their identification and localization within biological tissue samples. MSI is an interdisciplinary science that crosses the borders of physics, chemistry and biology, and enables local molecular analysis at a broad range of lengt...

journal_title：Current pharmaceutical design

authors： Barre FPY,Heeren RMA,Potocnik NO

更新日期：2017-01-01 00:00:00

abstract：:New biopharmaceutical molecules, potentially able to provide more personalized and effective treatments, are being identified through the advent of advanced synthetic biology strategies, sophisticated chemical synthesis approaches, and new analytical methods to assess biological potency. However, translation of many o...

journal_title：Current pharmaceutical design

authors： Munsell EV,Ross NL,Sullivan MO

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Familial Hypercholesterolaemia (FH) is an autosomal-dominant genetic disease and represents the most common genetic disorder: heterozygous 1/250 births, homozygous 1/300, 000 births. FH is characterized by high to very high low-density lipoprotein cholesterol (LDL-C), which is the main cause of increased inc...

journal_title：Current pharmaceutical design

authors： Viigimaa M,Heinsar S,Lovic D,Katsimardou A,Piperidou A,Duishvili D

更新日期：2018-01-01 00:00:00

abstract：:Erectile function is determined by tight regulation of relaxation or contraction of corpus cavernosal smooth muscle, which is the result of a long and complex chain of molecular events. Control of erectile function resides in signaling pathways of the central and peripheral nervous system, as well as intracellular eve...

journal_title：Current pharmaceutical design

authors： Seftel AD

更新日期：2005-01-01 00:00:00

abstract：:Growth differentiation factor 5 (GDF5) is a member of the bone morphogenic protein (BMP) family and plays critical roles in organ development processes including bone, cartilage, ligament, and joint formation. GDF5 is expressed in the cartilage primordium in the early limb development, and in the interzone of joint fo...

journal_title：Current pharmaceutical design

authors： Jin L,Li X

更新日期：2013-01-01 00:00:00

abstract：:Urological cancer refers to cancer in organs of the urinary system and the male reproductive system. It mainly includes prostate cancer, bladder cancer, renal cancer, etc., seriously threatening patients' survival. Although there are many advances in the treatment of urological cancer, approved targeted therapies ofte...

journal_title：Current pharmaceutical design

authors： Liu Q,Gu J,Zhang E,He L,Yuan ZX

更新日期：2020-01-01 00:00:00

abstract：:Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14). Pharmacological experiments indi...

journal_title：Current pharmaceutical design

authors： Müller CE

更新日期：2002-01-01 00:00:00

abstract：:Active pharmaceutical ingredients (APIs) can exist in different polymorphic forms as well as in amorphous state. Polymorphic and amorphous forms of APIs can differ in physicochemical properties which in turn can significantly influence their therapeutic safety and effectiveness of the treatment. This review focuses on...

journal_title：Current pharmaceutical design

authors： Talaczynska A,Dzitko J,Cielecka-Piontek J

更新日期：2016-01-01 00:00:00

abstract：:Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they devel...

journal_title：Current pharmaceutical design

authors： Kolovou G,Anagnostopoulou K,Mikhailidis DP,Cokkinos DV

更新日期：2008-01-01 00:00:00

abstract：:Medicinal inorganic chemistry plays an important role in exploring the properties of metal ions for the designing of new drugs. The field has been stimulated by the success of cis-platin, the world best selling anticancer drug and platinum complexes with reduced toxicity, oral activity and activity against resistant t...

journal_title：Current pharmaceutical design

authors： Sirajuddin M,Ali S

更新日期：2016-01-01 00:00:00

abstract：:Cumulative scientific evidence gathered over the past ten years has confirmed the role of platelet GP IIb/IIIa inhibitors in reducing ischemic complications of patients undergoing percutaneous coronary intervention (PCI). Recently, mortality data available on more than 20,000 patients enrolled in randomized clinical t...

journal_title：Current pharmaceutical design

authors： Dery JP,Harrington RA,Tcheng JE

更新日期：2004-01-01 00:00:00

abstract：:Myocarditis is a disease whose pathogenesis is not completely understood and whose prevalence is likely underestimated. Individuals afflicted with this condition may be treated with agents that relieve symptoms arising from inflammation and concurrent cellular damage. One class of drugs commonly used in the treatment ...

journal_title：Current pharmaceutical design

authors： Godsel LM,Leon JS,Engman DM

更新日期：2003-01-01 00:00:00

abstract：:Histone deacetylases (HDACs) are important enzymes that effect post-translational modifications of proteins by altering the acetylation state of lysine residues. HDACs control epigenetic changes that trigger cell transformation and proliferation of transformed cells associated with many diseases. These enzymes are val...

journal_title：Current pharmaceutical design

authors： Andrews KT,Tran TN,Fairlie DP

更新日期：2012-01-01 00:00:00

abstract：:Carboxylic acids are an important natural component as a final product or intermediates for syntheses. They are produced in plants, animals and also as products from biotechnological processes. This review presents the use of single hydroxide particles and layered double hydroxides as alternative adsorbents to remove ...

journal_title：Current pharmaceutical design

authors： Rodriguez LEG,Bail A,Castillo RO,Arízaga GGC

更新日期：2020-01-01 00:00:00

abstract：:An integrative synthesis of concepts and an explosion of experimental and epidemiological findings allow new insights as to how the interactions of genetic, environmental, dietary, cultural (social, psychological, economic) factors can influence the aging and diseases of aging processes. Although the net effect of the...

journal_title：Current pharmaceutical design

authors： Trosko JE

更新日期：2008-01-01 00:00:00

abstract：:From a complications standpoint, diabetes mellitus is a disease of the vasculature. Diabetics face a considerably higher risk of developing cardiovascular and cerebrovascular diseases. Both large and small blood vessels are susceptible to alterations from diabetes. Endothelial cell dysfunction associated with small ve...

journal_title：Current pharmaceutical design

authors： Huber JD

更新日期：2008-01-01 00:00:00

abstract：:Over the last several years, it has become increasingly clear that dendritic cells (DC) are not only critical for the initiation of T cell immunity, but these cells also determine the course of the subsequent immune response (i.e. tolerance vs. immunity, Th1 vs. Th2). However, the mechanisms by which DC can influence ...

journal_title：Current pharmaceutical design

authors： Wan Y,Bramson J

更新日期：2001-07-01 00:00:00

abstract：:The analysis of enantiorecognition processes involves the detection of enantiomeric species as well as the study of chiral discrimination mechanisms. In both fields Nuclear Magnetic Resonance (NMR) spectroscopy plays a fundamental role, providing several tools, based on the use of suitable chiral auxiliaries, for obse...

journal_title：Current pharmaceutical design

authors： Uccello-Barretta G,Balzano F,Salvadori P

更新日期：2006-01-01 00:00:00

abstract：:Two morphological features may be seen as a main result of the cardiovascular cell damage caused by cigarette smoking: myocardial cell necrosis and smoke cardiomyopathy that, however, can lead to cell necrosis in case of chronic prolonged exposure to tobacco smoke. Both these pathological patterns recognise hypoxia as...

journal_title：Current pharmaceutical design

authors： Leone A,Landini L Jr,Biadi O,Balbarini A

更新日期：2008-01-01 00:00:00

abstract：:Angiogenic eye disease is among the most common causes of blindness worldwide. Current treatment approaches are insufficiently effective and partially associated with significant adverse effects. From an investigational view, the eye provides an ideal setting to observe real-time and serial observations of angiogenesi...

journal_title：Current pharmaceutical design

authors： Wegewitz U,Göhring I,Spranger J

更新日期：2005-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical design

authors： Di Martino P

更新日期：2019-01-01 00:00:00

abstract：:The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells an...

journal_title：Current pharmaceutical design

authors： Leonarduzzi G,Sottero B,Testa G,Biasi F,Poli G

更新日期：2011-12-01 00:00:00