Strategies for skeletal muscle targeting in drug discovery.

abstract：:The skin remains an attractive area for drug delivery. The skin, however, often limits the ingress of drugs, because of its very low permeability. Much research, focusing on employing a variety of physical and chemical methods, aimed at reversibly altering skin permeability in favour of compounds, has been reported. O...

journal_title：Current pharmaceutical design

authors： Kilian D,Shahzad Y,Fox L,Gerber M,Du Plessis J

更新日期：2015-01-01 00:00:00

abstract：:In order to productively infect a host, viruses must enter the cell and force host cell replication mechanisms to produce new infectious virus particles. The success of this process unfortunately results in disease progression and, in the case of infection with many viral species, may cause mortality. The discoveries ...

journal_title：Current pharmaceutical design

authors： Skoreński M,Sieńczyk M

更新日期：2013-01-01 00:00:00

abstract：:A positive relationship between stress tolerance and longevity has been observed in several model systems. That the same correlation is applicable in humans and that it may be open to experimental manipulation for extending human lifespan requires studies on association of stress genes with longevity. The involvement ...

journal_title：Current pharmaceutical design

authors： Singh R,Kølvraa S,Bross P,Christensen K,Bathum L,Gregersen N,Tan Q,Rattan SI

更新日期：2010-01-01 00:00:00

abstract：:Two morphological features may be seen as a main result of the cardiovascular cell damage caused by cigarette smoking: myocardial cell necrosis and smoke cardiomyopathy that, however, can lead to cell necrosis in case of chronic prolonged exposure to tobacco smoke. Both these pathological patterns recognise hypoxia as...

journal_title：Current pharmaceutical design

authors： Leone A,Landini L Jr,Biadi O,Balbarini A

更新日期：2008-01-01 00:00:00

abstract：:The rise of multi-drug resistant and extensively drug resistant M. tuberculosis around the world poses a great threat to human health, and necessitates development of new, effective and inexpensive anti-tubercular agents. The availability of knowledge on molecular biology of M. tuberculosis infection coupled with whol...

journal_title：Current pharmaceutical design

authors： Chauhan RS,Chanumolu SK,Rout C,Shrivastava R

更新日期：2014-01-01 00:00:00

abstract：:Transient left ventricular dysfunction in patients under emotional stress, also known as Takotsubo cardiomyopathy, has been recognized as a distinct clinical entity. Recent studies have supported the concept notion that the cardiovascular system is regulated by cortical modulation. A network consisting of the insular ...

journal_title：Current pharmaceutical design

authors： Nagai M,Dote K,Kato M,Sasaki S,Oda N,Kagawa E,Nakano Y,Yamane A,Higashihara T,Miyauchi S,Tsuchiya A,Harada W,Kario K

更新日期：2017-01-01 00:00:00

abstract：:The metabolic syndrome (MetS) represents a cluster of medical disorders, such as hyperglycemia, dyslipidemia, hypertension, and abdominal obesity that, when occurring together, increase the risk of developing cardiovascular disease. The role of food and nutrients in the aetiology of chronic diseases has become clearer...

journal_title：Current pharmaceutical design

authors： Grosso G,Mistretta A,Marventano S,Purrello A,Vitaglione P,Calabrese G,Drago F,Galvano F

更新日期：2014-01-01 00:00:00

abstract：:Inflammatory and infectious diseases include many different clinical conditions not often well recognised and characterized with conventional radiology and biochemical tests. Radiological techniques (TC, MRI, US) show anatomical changes that usually occur in chronic stages of the disease leading to a delayed diagnosis...

journal_title：Current pharmaceutical design

authors： Signore A,Lauri C,Galli F

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Polyphenols are a family of natural antioxidants that in recent years have been studied and tested for their potential benefits towards cardiovascular diseases. OBJECTIVE:The aim of this review is to focus the attention on the presumed lipid-lowering and atheroprotective effects of polyphenols, administered...

journal_title：Current pharmaceutical design

authors： Cicero AFG,Colletti A

更新日期：2018-01-01 00:00:00

abstract：:Pancreatic cancer is one of the most fatal human malignancies. Though a relatively rare malignancy, it remains one of the deadliest tumors, with an extremely high mortality rate. The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a com...

journal_title：Current pharmaceutical design

authors： Liu H,Ma Q,Xu Q,Lei J,Li X,Wang Z,Wu E

更新日期：2012-01-01 00:00:00

abstract：:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human di...

journal_title：Current pharmaceutical design

authors： Tomé-Carneiro J,Larrosa M,González-Sarrías A,Tomás-Barberán FA,García-Conesa MT,Espín JC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:Nowadays, the world is facing a common problem that the population aging process is accelerating. How to delay metabolic disorders in middle-aged and elderly people, has become a hot scientific and social issue worthy of attention. The liver plays an important role in lipid metabolism, and abnormal li...

journal_title：Current pharmaceutical design

authors： Su H,Liu D,Shao J,Li Y,Wang X,Gao Q

更新日期：2020-01-01 00:00:00

abstract：BACKGROUNDS:Targeted therapy is the foundation of personalized medicine in cancer, which is often understood as the right patient using the right drug. Thinking from the viewpoint of determinants during personalized drug treatment, the genetics, epigenetics and metagenomics would provide individual-specific biological ...

journal_title：Current pharmaceutical design

authors： Wang L,Yu X,Zhang C,Zeng T

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease has been the leading cause of death in both sexes in developed countries for decades. In general, men and women share the same cardiovascular risk factors. However, in recent trials including both men and women sexspecific analyses have raised awareness of sex differences in cardiovasc...

journal_title：Current pharmaceutical design

authors： Pedersen LR,Frestad D,Michelsen MM,Mygind ND,Rasmusen H,Suhrs HE,Prescott E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The development of appropriate pharmaceutical formulations for routine neonatal practice is challenging because of the developmental characteristics and the need for it to be specifically ageappropriate. This has led to wide use of extemporaneous formulations, which lack standardized procedures that can resu...

journal_title：Current pharmaceutical design

authors： Kogermann K,Lass J,Nellis G,Metsvaht T,Lutsar I

更新日期：2017-01-01 00:00:00

abstract：:Nanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The advantageous properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload...

journal_title：Current pharmaceutical design

authors： Maya S,Sarmento B,Nair A,Rejinold NS,Nair SV,Jayakumar R

更新日期：2013-01-01 00:00:00

abstract：:In the early 1980s, an "atypical" beta-adrenergic receptor was discovered and subsequently called the beta (3)-adrenoceptor (beta(3)-AR). Agonists of the beta(3)-AR were observed to simultaneously increase lipolysis, fat oxidation, energy expenditure and insulin action leading to the belief that this receptor might se...

journal_title：Current pharmaceutical design

authors： de Souza CJ,Burkey BF

更新日期：2001-09-01 00:00:00

abstract：:Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, thereby upregulating gonadotrophin secretion and release from the pituitary. Hence, Tamoxifen is used to upregulate activatio...

journal_title：Current pharmaceutical design

authors： Dimakopoulou A,Foran D,Jayasena CN,Minhas S

更新日期：2020-02-12 00:00:00

abstract：:Crohn's disease and ulcerative colitis are the two principal forms of inflammatory bowel disease (IBD). The root causes of these chronic and acute immunological disorders are unclear, but intestinal microorganisms are known to play a key role in the initiation and maintenance of disease. However, at present, there is ...

journal_title：Current pharmaceutical design

authors： Macfarlane GT,Blackett KL,Nakayama T,Steed H,Macfarlane S

更新日期：2009-01-01 00:00:00

abstract：:DAP12 is a novel immunoreceptor tyrosine-based activation motifs (ITAM)-bearing transmembrane adapter molecule. This molecule, together with its partner receptor complex molecules including the killer cell activating receptors (KARs), myeloid DAP12 associating lectin-1 (MDL-1), triggering receptor expressed on myeloid...

journal_title：Current pharmaceutical design

authors： Aoki N,Kimura S,Xing Z

更新日期：2003-01-01 00:00:00

abstract：:Stimulant use disorders are an unrelenting public health concern worldwide. Agonist replacement therapy is among the most effective strategies for managing substance use disorders including nicotine and opioid dependence. The present paper reviewed clinical data from human laboratory self-administration studies and cl...

journal_title：Current pharmaceutical design

authors： Stoops WW,Rush CR

更新日期：2013-01-01 00:00:00

abstract：:Most heterosexual women want to reduce the risk of acquiring a sexually transmitted infection; many also want to control their fertility. Several chemical agents have been proposed to dramatically slow the spread of HIV infections. Ideally, vaginal microbicides, with or without contraceptive properties, should be safe...

journal_title：Current pharmaceutical design

authors： Gandour RD

更新日期：2005-01-01 00:00:00

abstract：:Natural products, or their synthetic derivatives are a treasure trove to find potential candidates for novel drugs for human treatment. The selection of diamonds from the huge pile of worthless stone is a critical--and difficult--stage in the discovery pipeline. Of all the factors to be considered, perhaps the most im...

journal_title：Current pharmaceutical design

authors： Wrzesinski K,Fey SJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. METHODS:The presented article will provide an overview on...

journal_title：Current pharmaceutical design

authors： Peters FT,Wissenbach DK,Busardo FP,Marchei E,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:Epicardial adipose tissue is not only a specific adipose tissue depot but also an active endocrine organ producing numerous substances with an important role in the development of obesity-related heart diseases. It is located between myocardium and visceral pericardium and consists predominantly of adipocytes, immunoc...

journal_title：Current pharmaceutical design

authors： Matloch Z,Cinkajzlova A,Mraz M,Haluzik M

更新日期：2018-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with premature mortality, severe morbidity, and functional impairment leading to considerable financial burden for both patients and society. Since disease progression and complications can differ from one patient to another, genetic markers are of...

journal_title：Current pharmaceutical design

authors： Rodriguez-Rodriguez L,López-Mejias R,Fernández-Gutiérrez B,Balsa A,González-Gay MA,Martín J

更新日期：2015-01-01 00:00:00

abstract：Background:Capsinoids (CSN), the novel non-pungent capsaicin analogs have been reported to promote metabolic health and exercise tolerance. However, the effect of CSN on fat oxidation and changes in skeletal muscle glycogen levels during post-exercise recovery has not been investigated in humans. Purpose:We examined t...

journal_title：Current pharmaceutical design

authors： Liao SF,Korivi M,Tsao JP,Huang CC,Chang CC,Cheng IS

更新日期：2020-08-23 00:00:00

abstract：BACKGROUND:Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnes...

journal_title：Current pharmaceutical design

authors： Giglio RV,Patti AM,Cicero AFG,Lippi G,Rizzo M,Toth PP,Banach M

更新日期：2018-01-01 00:00:00

abstract：:The American Academy of Pediatrics has proposed guidelines for treating term/near term infants with hyperbilirubinemia based primarily on maintaining the total serum bilirubin concentration (TSB) below a "critical" level of 25 mg/dL (426 micromol/L). We estimated the sensitivity and specificity of this critical TSB us...

journal_title：Current pharmaceutical design

authors： Wennberg RP,Ahlfors CE,Aravkin AY

更新日期：2009-01-01 00:00:00

abstract：:The present review discusses the mechanism of late stent thrombosis and its distinction from restenosis and summarizes the advisory note issued by FDA on the proper usage of different treatments available for atherosclerosis. In light of the latest developments, a plethora of new stents have been and continue to be de...

journal_title：Current pharmaceutical design

authors： Rastogi A,Stavchansky S

更新日期：2008-01-01 00:00:00