Neuropsychiatric involvement in systemic lupus erythematosus: current therapeutic approach.

abstract：:Pancreatic cancer is one of the most fatal human malignancies. Though a relatively rare malignancy, it remains one of the deadliest tumors, with an extremely high mortality rate. The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a com...

journal_title：Current pharmaceutical design

authors： Liu H,Ma Q,Xu Q,Lei J,Li X,Wang Z,Wu E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Medical treatments are used either alone or in combination with assisted reproductive techniques for treatment of infertile patients with hypergonadotropic hypogonadism. A wide range of treatment options such as gonadotropins, aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs) and the...

journal_title：Current pharmaceutical design

authors： Kalkanli A,Akdere H,Cevik G,Salabas E,Cilesiz NC,Kadioglu A

更新日期：2020-11-01 00:00:00

abstract：:Despite the significant progresses made in antiretroviral therapy, current drugs still cannot cure or prevent HIV infection. And all drugs continue to select for drug-resistant HIV strains. Consequently, new antiretroviral drugs are constantly being developed. To ensure safety, these drugs are usually designed to inhi...

journal_title：Current pharmaceutical design

authors： Provencher VM,Coccaro E,Lacasse JJ,Schang LM

更新日期：2004-01-01 00:00:00

abstract：:Hyperferritinemia is observed in one-third of patients with non-alcoholic fatty liver disease (NAFLD) and Metabolic Syndrome (MetS). The condition characterized by increased body iron stores associated with components of MetS has been defined as Dysmetabolic Iron Overload Syndrome (DIOS). DIOS represents the most freq...

journal_title：Current pharmaceutical design

authors： Rametta R,Fracanzani AL,Fargion S,Dongiovanni P

更新日期：2020-01-01 00:00:00

abstract：:Retinoids (vitamin A and its analogs) exert profound effects on a wide variety of life processes, including morphogenesis and embryonic development. Several retinoids are also effective drugs for therapy of skin diseases and some types of cancer. However, the applicability of this class of compounds is limited by thei...

journal_title：Current pharmaceutical design

authors： Tzimas G,Nau H

更新日期：2001-06-01 00:00:00

abstract：:Invasive fungal infections are a major cause of morbidity and mortality in immunosuppressed patients with fatality rates ranging from 30 % to 80 % in neutropenic patients. This results at least partly in difficulties obtaining a reliable and early diagnosis, followed by the fact that clinical symptoms are unspecific a...

journal_title：Current pharmaceutical design

authors： Lackner M,Lass-Flörl C

更新日期：2013-01-01 00:00:00

abstract：:Gestational diabetes mellitus is a common metabolic complication of pregnancy. Universal guidelines on gestational diabetes have been impeded by the long-term controversies on its definition and screening strategies. The prevalence of gestational diabetes is rising all over the world, is significantly influenced by et...

journal_title：Current pharmaceutical design

authors： Kousta E,Kontogeorgi A,Robinson S,Johnston DG

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Ultrasound contrast agents involving a therapeutic drug applied during enhanced imaging can be used for targeted therapy. The preparation of contrast agents is a precondition and basis for the use of multifunctional contrast agents in molecular imaging. METHODS:This study uses thin-film hydration-mechanical vi...

journal_title：Current pharmaceutical design

authors： Yang F,Li Y,Liufu C,Wang Y,Chen Z

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The use of aromatic plants to relief different illness is not a new therapy. Actually aromatic plants have been used for many centuries by different cultures around the world. Pharmacological studies provide scientific support to the traditional use of aromatic medicinal plants and aromatherapy; nevertheless...

journal_title：Current pharmaceutical design

authors： Maggio A,Rosselli S,Bruno M

更新日期：2016-01-01 00:00:00

abstract：:Patients with diabetes mellitus (DM) type 2 have a high prevalence of coronary artery disease (CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Hyperglycemia, elevated free fatty acid, increased amount of circulating end-glucosylated serum products and insulin resistance are the main mechani...

journal_title：Current pharmaceutical design

authors： Tousoulis D,Kampoli AM,Papageorgiou N,Papaoikonomou S,Antoniades C,Stefanadis C

更新日期：2009-01-01 00:00:00

abstract：:There is now a large body of evidence that weight loss in older persons not only increases mortality, but also increases the incidence of hip fracture, functional deterioration and institutionalization. Weight loss is a central component of frailty. There is evidence that it is not only muscle, but also fat loss that ...

journal_title：Current pharmaceutical design

authors： Morley JE

更新日期：2007-01-01 00:00:00

abstract：:The review describes key aspects of the synthesis and biological activities of conjugates of oligonucleotides and their analogues with synthetic peptides, in particular aimed towards gene silencing applications. The common methods of synthesis of oligonucleotide-peptide conjugates (OPCs) and PNA-peptide conjugates (PP...

journal_title：Current pharmaceutical design

authors： Zatsepin TS,Turner JJ,Oretskaya TS,Gait MJ

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research focused on identifying compounds that restore cognition and memory in AD patients is a very active investigational pursuit, but unfortunately, it has been only successful in terms of developing symptomatic treatments. Aβ deposition a...

journal_title：Current pharmaceutical design

authors： Solas M,Puerta E,Ramirez MJ

更新日期：2015-01-01 00:00:00

abstract：:Bisphosphonates are widely use for pathologies such as osteoporosis, Paget's disease or bone metastasis. However, their potent antiresorptive properties open new therapeutic opportunities for other conditions associated with an increased focal or systemic bone remodelling. Moreover, apart from their antiresorptive act...

journal_title：Current pharmaceutical design

authors： Le Goff B,Berthelot JM,Maugars Y,Romas E

更新日期：2010-01-01 00:00:00

abstract：:NAP (davunetide) is an eight amino acid peptide (NAPVSIPQ) that has been shown to provide potent neuroprotection, in vitro and in vivo. In human clinical trials, NAP has been shown to increase memory scores in patients suffering from amnestic mild cognitive impairment, a precursor to Alzheimer's disease and to enhance...

journal_title：Current pharmaceutical design

authors： Gozes I

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Vitamin D exerts multiple pleiotropic effects beyond its role in calcium-phosphate metabolism. Growing evidence suggests an association between hypovitaminosis D and sleep disorders, thus increasing the interest in the role of this vitamin in the regulatory mechanisms of the sleep-wake cycle. OBJECTIVE:The ...

journal_title：Current pharmaceutical design

authors： Romano F,Muscogiuri G,Di Benedetto E,Zhukouskaya VV,Barrea L,Savastano S,Colao A,Di Somma C

更新日期：2020-01-01 00:00:00

abstract：:The maintenance and regulation of cellular NAD(P)(H) content and its influence on cell function involves many metabolic pathways, some of which remain poorly understood. Niacin deficiency in humans, which leads to low NAD status, causes sun sensitivity in skin, indicative of deficiencies in responding to UV damage. An...

journal_title：Current pharmaceutical design

authors： Benavente CA,Jacobson MK,Jacobson EL

更新日期：2009-01-01 00:00:00

abstract：:Cytokines are known to play a key role in regulation of gastric functions. Interferon-alpha (IFN-α) has been published to impair gastric motility. Aims of this study were to clarify effect of IFN-α on gastric acid secretion (GAS) and determine role of nitric oxide (NO) in the process. Both subcutaneous (1000, 10000, 1...

journal_title：Current pharmaceutical design

authors： Czimmer J,Király Á,Szabó IL,Mózsik G,Sütő G

更新日期：2013-01-01 00:00:00

abstract：:Subjects affected by ischemic heart disease with non-obstructive coronary arteries constitute a population that has received increasing attention over the past two decades. Since the first studies with coronary angiography, female patients have been reported to have non-obstructive coronary artery disease more frequen...

journal_title：Current pharmaceutical design

authors： Bergami M,Scarpone M,Cenko E,Varotti E,Amaduzzi PL,Manfrini O

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Human brain is amongst the most complex organs in human body, and delivery of therapeutic agents across the brain is a tedious task. Existence of blood brain barrier (BBB) protects the brain from invasion of undesirable substances; therefore it hinders the transport of various drugs used for the treatment of...

journal_title：Current pharmaceutical design

authors： Mittal S,Ashhar MU,Qizilbash FF,Qamar Z,Narang JK,Kumar S,Ali J,Baboota S

更新日期：2020-01-01 00:00:00

abstract：:Adenosine is released in large amounts during myocardial ischemia and is capable of exerting potent cardioprotective effects in the heart. Although these observations on adenosine have been known for a long time, how adenosine acts to achieve its anti-ischemic effect remains incompletely understood. However, recent ad...

journal_title：Current pharmaceutical design

authors： Liang BT,Jacobson KA

更新日期：1999-12-01 00:00:00

abstract：:The apoptosis inducing factor (AIF) was first discovered as a caspase-independent apoptosis effector that promoted cell death upon release from the mitochondria (triggered by pro-apoptotic stimuli) and relocalization into the nucleus, where it promotes chromatin condensation and DNA fragmentation. AIF is a mammalian m...

journal_title：Current pharmaceutical design

authors： Ferreira P,Villanueva R,Cabon L,Susín SA,Medina M

更新日期：2013-01-01 00:00:00

abstract：:Dioxygen (O2) is an exogenously supplied gas with a number of properties that make it valuable as a biological source of energy and as a result much of life has become dependent on this molecule. Nitric oxide (NO), carbon dioxide (CO) and hydrogen sulfide (H2S) are small molecules that are sometimes in a gaseous state...

journal_title：Current pharmaceutical design

authors： Fukuto JM,Collins MD

更新日期：2007-01-01 00:00:00

abstract：:Infections are the most common inflammatory triggers and acute and chronic infections have been associated with the development and progression of atherosclerotic disease raising interest in the infectious hypothesis of atherosclerosis. Pathogens have been identified in atherosclerotic plaques and large epidemiologica...

journal_title：Current pharmaceutical design

authors： Charakida M,Tousoulis D

更新日期：2013-01-01 00:00:00

abstract：:Several lines of evidence support a mutual relationship between the nervous system and the immune system. Therefore, it is not surprising that some neuropsychiatric disorders are also characterized by immune abnormalities. In patients with phobic disorders and in patients with migraine without aura some common immune ...

journal_title：Current pharmaceutical design

authors： Covelli V,Pellegrino NM,Jirillo E

更新日期：2003-01-01 00:00:00

abstract：:The aging phenomenon is intrinsically responsible for diseases and lifestyle-associated conditions afflicting the aging male. In particular, male infertility seems to result from deleterious lifestyle choices. However, the aging effect at the individual gene/protein level is poorly discussed and valuable information i...

journal_title：Current pharmaceutical design

authors： Bastos P,Freitas MJ,Gomes A,Vitorino R,Fardilha M

更新日期：2017-11-28 00:00:00

abstract：:Thrombotic events occurring in either arteries or veins are the primary causes of fatal perioperative cardiovascular events. Risk factors for deep vein thrombosis, several of which are evidently associated with specific surgical procedures, are quite different from those for arterial thrombosis (e.g., aging or atheros...

journal_title：Current pharmaceutical design

authors： Azma T,Tuluc F,Ito T,Aoyama-Mani C,Kawahito S,Kinoshita H

更新日期：2014-01-01 00:00:00

abstract：:siRNA-induced RNA Interference (RNAi) responses have great potential to treat human disease; however, siRNAs are highly charged macromolecules with no ability to enter cells and require a delivery agent. Peptide Transduction Domains (PTDs), also called Cell Penetrating Peptides (CPPs), are delivery peptides with the p...

journal_title：Current pharmaceutical design

authors： Presente A,Dowdy SF

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) has high mortality partly due to acquiring drug resistance during chemotherapy treatment. Therefore, it is necessary to explore the underlying mechanism of drug resistance. METHODS:We used 2-DE and MALDI-TOF-MS analysis to explore the possible molecular insight into 5-FU resis...

journal_title：Current pharmaceutical design

authors： Tan Y,Qin S,Hou X,Qian X,Xia J,Li Y,Wang R,Chen C,Yang Q,Miele L,Wu Q,Wang Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Cancer is the world's second-largest cause of death, with an estimated 9.6 million fatalities in 2018. Malignant tumour (cancer) is caused by a mixture of genetic modifications due to the environmental variables that tend to activate or inactivate different genes, ultimately resulting in neoplastic transform...

journal_title：Current pharmaceutical design

authors： Jindal M,Nagpal M,Singh M,Aggarwal G,Dhingra GA

更新日期：2020-01-01 00:00:00