Can haemostatic factors predict atherothrombosis?


:Thrombosis is "haemostasis in the wrong place", and there is increasing evidence that haemostatic factors are associated with increased risk of atherothrombotic events. Increasing plasma levels of fibrinogen are associated with increased risks of coronary heart disease, stroke and peripheral arterial disease, and with vascular and nonvascular mortality. However, as with other markers of haemostasis (and of inflammation), their additional predictive value to conventional risk factors is small. Ongoing studies of activation markers of coagulation (e.g. fibrin D-dimer), endothelium (e.g. von Willebrand factor, tissue plasminogen activator antigen) and platelets (mean platelet volume) may provide additional predictive value for atherothrombotic events. However, at present there is no sufficient evidence base for their routine measurement in prediction.


Intern Emerg Med


Lowe G




Has Abstract


2011-12-01 00:00:00












  • An Italian version of the Ottawa Crisis Resource Management Global Rating Scale: a reliable and valid tool for assessment of simulation performance.

    abstract::Objective measurement of simulation performance requires a validated and reliable tool. However, no published Italian language assessment tool is available. Translation of a published English language tool, the Ottawa Crisis Resource Management Global Rating Scale (GRS), may lead to a validated and reliable tool. Afte...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Franc JM,Verde M,Gallardo AR,Carenzo L,Ingrassia PL

    更新日期:2017-08-01 00:00:00

  • Clinical assessment of endothelial function in patients with chronic obstructive pulmonary disease: a systematic review with meta-analysis.

    abstract::Patients with chronic obstructive pulmonary disease (COPD) have an increased cardiovascular morbidity and mortality. Flow-mediated (FMD) and nitrate-mediated dilatation (NMD) are considered non-invasive methods to assess endothelial function and surrogate markers of subclinical atherosclerosis. We performed a systemat...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Ambrosino P,Lupoli R,Iervolino S,De Felice A,Pappone N,Storino A,Di Minno MND

    更新日期:2017-09-01 00:00:00

  • Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients.

    abstract::Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper endoscopy for dyspe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Dore MP,Marras G,Rocchi C,Soro S,Loria MF,Bassotti G,Graham DY,Malaty HM,Pes GM

    更新日期:2015-10-01 00:00:00

  • Association of physician experience with a higher prescription rate of anti-influenza agents in low-risk patients.

    abstract::During the influenza season, most patients suspected of having influenza undergo rapid influenza diagnostic tests (RIDTs) in Japan despite their low sensitivity. However, the physician's actual rationale for prescribing antivirals, besides the results of RIDTs, remains poorly understood. Our study sought to identify t...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Nakajima K,Akebo H,Tsugihashi Y,Ishimaru H,Sada R

    更新日期:2021-01-02 00:00:00

  • Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience.

    abstract::The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Valente S,Lazzeri C,Chiostri M,Alterini B,Ognibene A,Giglioli C,Pigozzi C,Gensini GF

    更新日期:2013-06-01 00:00:00

  • Anticoagulant therapy in the treatment of splanchnic vein thrombosis associated to acute pancreatitis: a 3-year single-centre experience.

    abstract::Splanchnic vein thrombosis (SVT) is a possible complication of acute pancreatitis (AP). There are no precise guidelines on the use of anticoagulant therapy (AT) in these patients. The aim of the study was to determine the safety and the efficacy of AT in AP-associated SVT. Two hundred twenty-one patients were retrospe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Pagliari D,Cianci R,Brizi MG,Mancarella FA,Musso M,Cintoni M,Franza L,Flore RA,Gasbarrini A,Tondi P

    更新日期:2020-09-01 00:00:00

  • Comparison of lercanidipine plus hydrochlorothiazide vs. lercanidipine plus enalapril on micro and macrocirculation in patients with mild essential hypertension.

    abstract::Dihydropyridine calcium channel blockers may possess antioxidant properties, and might improve micro and macrovascular structure and function. Combination treatment with an ACE inhibitor may have additional advantages, compared with a thiazide diuretic. The aim of the present study is to investigate the effects of a s...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: De Ciuceis C,Salvetti M,Paini A,Rossini C,Muiesan ML,Duse S,Caletti S,Coschignano MA,Semeraro F,Trapletti V,Bertacchini F,Brami V,Petelca A,Agabiti Rosei E,Rizzoni D,Agabiti Rosei C

    更新日期:2017-10-01 00:00:00

  • Changes in erythropoiesis, iron metabolism and oxidative stress after half-marathon.

    abstract:OBJECTIVE:In marathon runners changes in red blood cell count, haematocrit and haemoglobin in relation to haemodilution have been reported. Moreover, it has been hypothesized that strenuous exercise induces oxidant stress through several different mechanisms. This study investigated the haematological variables, iron s...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Duca L,Da Ponte A,Cozzi M,Carbone A,Pomati M,Nava I,Cappellini MD,Fiorelli G

    更新日期:2006-01-01 00:00:00

  • Extreme hypomagnesemia: characteristics of 119 consecutive inpatients.

    abstract::Extreme hypomagnesemia (hypoMg) can be encountered in many situations, but little data currently exist. Our aim is to describe the epidemiological, clinical, etiological characteristics, and the biological abnormalities of consecutive inpatients with extreme hypomagnesemia. In our observational monocentric study, betw...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Cheminet G,Clain G,Jannot AS,Ranque B,Passeron A,Michon A,De Luna G,Diehl JL,Oudard S,Cellier C,Karras A,Vedié B,Prot-Bertoye C,Pouchot J,Arlet JB

    更新日期:2018-12-01 00:00:00

  • A simple lung ultrasound protocol for the screening of COVID-19 pneumonia in the emergency department.

    abstract::The most relevant manifestation of coronavirus disease 2019 (COVID-19) is interstitial pneumonia. Several lung ultrasound (US) protocols for pneumonia diagnosis are used in clinical practice, but none has been proposed for COVID-19 patients' screening in the emergency department. We adopted a simplified 6-scan lung US...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Dacrema A,Silva M,Rovero L,Vertemati V,Losi G,Piepoli MF,Sacchi R,Mangiacotti M,Nazerian P,Pagani L,Tinelli V,Poggiali E,Bastoni D,Vercelli A,Magnacavallo A

    更新日期:2021-01-11 00:00:00

  • Cardiovascular and metabolic risks associated with PCOS.

    abstract::Polycystic ovary syndrome, the most common endocrine disorder of reproductive age women, is often associated with insulin resistance and associated disorders. The frequency of type 2 diabetes, hyperlipidemia, cardiac risk markers, structural vascular disease, and clinical disease events are increased in this populatio...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Cobin RH

    更新日期:2013-04-01 00:00:00

  • Subclinical liver fibrosis in patients with idiopathic pulmonary fibrosis.

    abstract::Data on the presence of subclinical fibrosis across multiple organs in patients with idiopathic lung fibrosis (IPF) are lacking. Our study aimed at investigating through hepatic transient elastography (HTE) the prevalence and clinical impact of subclinical liver fibrosis in a cohort of patients with IPF. Patients refe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Cocconcelli E,Tonelli R,Abbati G,Marchioni A,Castaniere I,Pelizzaro F,Russo FP,Vegetti A,Balestro E,Pietrangelo A,Richeldi L,Luppi F,Spagnolo P,Clini E,Cerri S

    更新日期:2020-05-25 00:00:00

  • Italian intersociety consensus on DOAC use in internal medicine.

    abstract::The direct oral anticoagulants (DOACs) are drugs used in clinical practice since 2009 for the prevention of stroke or systemic embolism in non-valvular atrial fibrillation, and for the treatment and secondary prevention of venous thromboembolism. The four DOACs, including the three factor Xa inhibitors (rivaroxaban, a...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Prisco D,Ageno W,Becattini C,D'Angelo A,Davì G,De Cristofaro R,Dentali F,Di Minno G,Falanga A,Gussoni G,Masotti L,Palareti G,Pignatelli P,Santi RM,Santilli F,Silingardi M,Tufano A,Violi F,SIMI (Italian Society of Inte

    更新日期:2017-04-01 00:00:00

  • Prevalence and outcome of diuretic resistance in heart failure.

    abstract::Diuretic resistance (DR) is common in patients with decompensated heart failure (HF), and is associated with adverse outcomes. To determine the prevalence of DR and its impact on survival among patients with decompensated HF, we prospectively evaluated the prevalence and influence on prognosis of DR (defined as persis...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Trullàs JC,Casado J,Morales-Rull JL,Formiga F,Conde-Martel A,Quirós R,Epelde F,González-Franco Á,Manzano L,Montero-Pérez-Barquero M

    更新日期:2019-06-01 00:00:00

  • Prevalence and 1-year prognosis of transient heart failure following coronary revascularization.

    abstract::The occurrence of heart failure during the whole pre-discharge course of coronary revascularization, as far as its influence on subsequent prognosis, is poorly understood. The present study examined the effect of transient heart failure (THF) developing in the acute and rehabilitative phase on survival after coronary ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,多中心研究


    authors: Ambrosetti M,Griffo R,Tramarin R,Fattirolli F,Temporelli PL,Faggiano P,De Feo S,Vestri AR,Giallauria F,Greco C

    更新日期:2014-09-01 00:00:00

  • Cardiovascular oncology: a new discipline inside internal medicine?

    abstract::Cardiovascular disease and cancer incidence and prevalence have risen over the past few decades to become the leading causes of death. On the one hand, cancer patients will be treated with cardiotoxic chemotherapies; on the other, cardiovascular patients will receive a new diagnosis of cancer and will have to face tre...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Prisco D,D'Elios MM,Cenci C,Ciucciarelli L,Tamburini C

    更新日期:2014-06-01 00:00:00

  • Can C-reactive protein and white blood cell count alone rule out an urgent condition in acute abdominal pain?

    abstract::Up to 10% of all patients at the Emergency Department present for acute abdominal pain. The C-reactive protein (CRP) and white blood cell (WBC) are routinely determined as part of the workup of patients with abdominal pain. Three large prospective cohort studies comprising a total of 2961 adult patients with acute abd...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Paolillo C,Spallino I,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2016-02-01 00:00:00

  • Impact of comorbidity on outcome in kidney transplant recipients: a retrospective study in Italy.

    abstract::The aim of this study was to relate in-hospital mortality (IHM), cardiovascular events (CVEs) and non-immunologic comorbidity evaluated on the basis of International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codification, in Italian kidney transplant recipients (KTRs). We evaluated IHM...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Fabbian F,De Giorgi A,Manfredini F,Lamberti N,Forcellini S,Storari A,Todeschini P,Gallerani M,La Manna G,Mikhailidis DP,Manfredini R

    更新日期:2016-09-01 00:00:00

  • The role of the combination of echo-HRCT score as a tool to evaluate the presence of pulmonary hypertension in idiopathic pulmonary fibrosis.

    abstract::Pulmonary hypertension (PH) is defined as an elevated mean pulmonary artery pressure at rest (mPAP ≥ 25 mmHg), evaluated by right heart catheterization (RHC). The aim of the present study was to evaluate HRCT findings in relation to transthoracic echocardiographic data to better characterize PH in IPF patients and to ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Refini RM,Bettini G,Kacerja E,Cameli P,d'Alessandro M,Bergantini L,De Negri F,Rottoli P,Sestini P,Bargagli E,Mazzei MA

    更新日期:2020-11-05 00:00:00

  • Bedside ultrasonography (US), Echoscopy and US point of care as a new kind of stethoscope for Internal Medicine Departments: the training program of the Italian Internal Medicine Society (SIMI).

    abstract::In recent years, thanks to the development of miniaturized ultrasound devices, comparable to personal computers, tablets and even to smart phones, we have seen an increasing use of bedside ultrasound in internal medicine departments as a novel kind of ultrasound stethoscope. The clinical ultrasound-assisted approach h...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Arienti V,Di Giulio R,Cogliati C,Accogli E,Aluigi L,Corazza GR,Ultrasound SIMI Study Group.

    更新日期:2014-10-01 00:00:00

  • Prevention of anthracycline-induced cardiotoxicity: a systematic review and meta-analysis.

    abstract::Anthracyclines are extensively used in oncologic patients, in particular for breast cancer and hematological malignancies. Cardiac injury is a potentially dangerous side effect of these drugs. In this systematic review, we analyzed published randomized controlled trials (RCTs) to assess if potential cardioprotective d...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Caspani F,Tralongo AC,Campiotti L,Asteggiano R,Guasti L,Squizzato A

    更新日期:2020-10-03 00:00:00

  • Cognitive impairment in patients hospitalized for congestive heart failure: data from the RICA Registry.

    abstract::The objective of this study is to determine the prevalence of cognitive impairment (CogI) in patients hospitalized for congestive heart failure, and the influence of CogI on mortality and hospital readmission. This is a multicenter cohort study of patients hospitalized for congestive heart failure enrolled in the RICA...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: García Bruñén JM,Povar Echeverria M,Díez-Manglano J,Manzano L,Trullàs JC,Romero Requena JM,Salamanca Bautista MP,González Franco Á,Cepeda Rodrigo JM,Montero-Pérez-Barquero M,RICA Investigators Group.

    更新日期:2021-01-01 00:00:00

  • Bronchoalveolar lavage and serum KL-6 concentrations in chronic hypersensitivity pneumonitis: correlations with radiological and immunological features.

    abstract::Chronic hypersensitivity pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from inhalation of different organic substances and chemical compounds determining an inflammatory and immunological response in sensitized individuals. KL-6, a human mucin protein expressed by type 2 pneumocytes, has be...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Lanzarone N,Gentili F,Alonzi V,Bergantini L,d'Alessandro M,Rottoli P,Refini RM,Pieroni M,Vietri L,Bianchi F,Mazzei MA,Volterrani L,Perrone A,Cameli P,Bargagli E,Sestini P

    更新日期:2020-10-01 00:00:00

  • Impact of gender on short-term and long-term all-cause mortality in patients with non-ST-segment elevation acute coronary syndromes: a meta-analysis.

    abstract::A meta-analysis to determine the impact of gender on mortality in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS): PubMed, EMBASE, and Cochrane Library, was systematically searched. Two investigators independently reviewed retrieved articles and assessed eligibility. Unadjusted mortality rat...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Wang Y,Zhu S,Du R,Zhou J,Chen Y,Zhang Q

    更新日期:2018-03-01 00:00:00

  • Drug-drug interactions in patients with acute coronary syndrome across phases of treatment.

    abstract::The objective of this study is to evaluate potential drug-drug interactions (pDDIs) and risk factors for pDDIs in three phases of an acute coronary syndrome (ACS) treatment: from the point of first medical contact to the coronary angiography (first phase), after coronary angiography to the last day of hospitalization ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Pejčić AV,Janković SM,Davidović G

    更新日期:2019-04-01 00:00:00

  • An attempt to measure the spread of emergency medicine internationally.

    abstract:OBJECTIVE:To determine the feasibility of using the internet to track the spread of emergency medicine internationally. METHODS: OVERVIEW:This was an attempt to perform a descriptive cross-sectional study employing a web-based survey. SUBJECTS:Potential respondents were identified from multiple sources. OBSERVATION...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Nagurney JT,Huang C,Kulkarni RG,Sane S,Davis MA,Anderson PD,Gaufberg SV,Ciottone GR,Motola I,Chang Y,Setnik G

    更新日期:2007-12-01 00:00:00

  • Association between in-hospital acute hypertensive episodes and outcomes in older trauma patients.

    abstract::Although chronic hypertension is associated with long-term complications, few studies directly examine the effects of in-hospital acute hypertensive episodes in trauma patients. The aim was to determine whether there is an association between in-hospital acute hypertension and morbidity. We included trauma patients be...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Saliba L,Stawicki SP,Thongrong C,Bergese SD,Papadimos TJ,Gerlach AT

    更新日期:2014-08-01 00:00:00

  • The management of patients with venous thromboembolism in Italy: insights from the PREFER in VTE registry.

    abstract::Venous thromboembolism (VTE) is the third most common cardiovascular disease. Real-life data on the clinical presentation, risk factors, diagnosis, and treatment of VTE in Italy and Europe are required to optimize the management of this disease. The PREFER in VTE registry, a prospective non-interventional real-life st...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Guercini F,Mommi V,Camporese G,Tonello C,Imberti D,Benedetti R,De Bartolomeo G,Di Lecce L,Romeo F,Agnelli G

    更新日期:2016-12-01 00:00:00

  • The prognostic role of gamma-glutamyltransferase activity in non-diabetic ST-elevation myocardial infarction.

    abstract::In patients with acute coronary syndrome, gamma-glutamyltransferase activity (GGT) proved to be an independent predictor of the development of major adverse cardiac events at early and long terms. No data are available on GGT in ST-elevation myocardial infarction (STEMI). We assessed, in 337 consecutive STEMI patients...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Lazzeri C,Valente S,Tarquini R,Chiostri M,Picariello C,Gensini GF

    更新日期:2011-06-01 00:00:00

  • NIV by an interdisciplinary respiratory care team in severe respiratory failure in the emergency department limited to day time hours.

    abstract::Non-invasive ventilatory support is frequently used in patients with severe respiratory failure (SRF), but is often limited to intensive care units (ICU). We hypothesized that an instantaneous short course of NIV (up to 2 h), limited to regular working hours as an additional therapy on the emergency department (ED) wo...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Horvath CM,Brutsche MH,Schoch OD,Schillig B,Baty F,vonOw D,Rüdiger JJ

    更新日期:2017-12-01 00:00:00