Abstract:
:Despite its rarity, infliximab-related hepatitis constitutes a cutting edge and challenging problem. In December 2004, a drug warning was issued by the Food and Drug Administration to alert healthcare professionals to the risk of hepatotoxicity in course of infliximab therapy. Subsequently, several reports of probable infliximab hepatitis have been published and interest is growing in trying to elucidate the impact of these events on clinical practice. After discussing our case report, the main characteristics of infliximab-mediated liver injury are analyzed, coupled with a review of the medical literature. Infliximab seems to provoke both immunomediated and a direct liver injury, but how this latter happens remains unclear. Moreover, infliximab immunomediated liver dysfunction resembles that of autoimmune hepatitis type I, with elevation of antinuclear, anti-smooth muscle, anti-double-strand DNA antibodies, and a clear preference for female sex. Finally, a flow chart is proposed with the purpose to help clinicians in the management of patients who develop signs of liver dysfunction during treatment with infliximab.
journal_name
Intern Emerg Medjournal_title
Internal and emergency medicineauthors
Mancini S,Amorotti E,Vecchio S,Ponz de Leon M,Roncucci Ldoi
10.1007/s11739-009-0342-4subject
Has Abstractpub_date
2010-06-01 00:00:00pages
193-200issue
3eissn
1828-0447issn
1970-9366journal_volume
5pub_type
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s11739-014-1100-9
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doi:10.1007/s11739-009-0231-x
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