Abstract：
:Whether there is a link between venous and arterial thrombotic disorders is still a matter of debate. They share common risk factors, such as old age, male sex and obesity. Endothelial dysfunction and inflammation are likely to play a role in determining the simultaneous involvement of the two vascular compartments. Unlike subclinical atherosclerosis, symptomatic complications of atherosclerosis such as myocardial infarction, ischemic stroke and atrial fibrillation are likely to predict the subsequent development of venous thromboembolic (VTE) complications. Patients with VTE, especially those with apparently unprovoked episodes, have a definitely increased risk of subsequent arterial thrombotic disorders. Drugs that reduce the risk of arterial thrombosis are likely to reduce the risk of venous thrombosis and vice versa. In particular, the direct oral anticoagulants have recently been shown to reduce the risk of both vascular disorders. In conclusion, recent evidence provides compelling evidence in support of the link between venous and arterial thrombosis. Future studies are needed to clarify the nature of this association, to assess its extent, and to evaluate its implications for clinical practice.
journal_name
Intern Emerg Medjournal_title
Internal and emergency medicineauthors
Prandoni Pdoi
10.1007/s11739-019-02238-6subject
Has Abstractpub_date
2020-01-01 00:00:00pages
33-36issue
1eissn
1828-0447issn
1970-9366pii
10.1007/s11739-019-02238-6journal_volume
15pub_type
杂志文章,评审abstract：:Antimicrobial therapy has been the main stay of therapy of community-acquired aspiration pneumonia (CAAP), but the duration of treatment has not been established. The objective of this study was to describe the time to reach clinical stability in patients with aspiration pneumonia compared to community-acquired pneumo...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-012-0764-2
更新日期：2014-03-01 00:00:00
abstract：:In patients with acute coronary syndrome, gamma-glutamyltransferase activity (GGT) proved to be an independent predictor of the development of major adverse cardiac events at early and long terms. No data are available on GGT in ST-elevation myocardial infarction (STEMI). We assessed, in 337 consecutive STEMI patients...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-010-0464-8
更新日期：2011-06-01 00:00:00
abstract：:The idea of using small RNA fragments (oligonucleotides) for therapeutic purposes dates back to the 1990s, following the landmark discoveries on the mechanisms of gene silencing and RNA-interference (RNA-i). However, the first applications in medicine were hampered by difficulties in chemical stabilization and efficie...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-018-1810-5
更新日期：2018-04-01 00:00:00
abstract：:Inflammation plays a pivotal role in all stages of atherosclerosis from endothelial dysfunction and plaque formation to plaque destabilization and disruption. Inflammatory biomarkers, originally studied to better understand the pathophysiology of atherosclerosis, have generated increasing interest among clinicians, be...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-010-0361-1
更新日期：2010-06-01 00:00:00
abstract：:Elderly patients are under-represented in trials assessing strategies of early coronary revascularization in acute myocardial infarction, though they are the fastest growing segment of our population. The aims of the present investigation, performed in 357 elderly (≥75 years) patients with ST elevation myocardial infa...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-010-0459-5
更新日期：2011-02-01 00:00:00
abstract：:Thrombosis is "haemostasis in the wrong place", and there is increasing evidence that haemostatic factors are associated with increased risk of atherothrombotic events. Increasing plasma levels of fibrinogen are associated with increased risks of coronary heart disease, stroke and peripheral arterial disease, and with...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11739-011-0536-4
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Patients with decompensated cirrhosis frequently require hospital admissions, which are associated with worse prognosis. The aim of this study was to analyze the effect of TIPS on the need for hospital care. Secondary objectives were to assess the clinical and biological impact of TIPS and to identi...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-020-02602-x
更新日期：2021-01-05 00:00:00
abstract：:Chronic thromboembolic pulmonary hypertension (CTPH) is a potential complication of pulmonary embolism (PE). Only few studies have assessed the role of brain natriuretic peptide (BNP) in patients with chronic pulmonary hypertension, and there are no data on the potential utility of BNP as a preclinical biomarker of CT...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-009-0231-x
更新日期：2009-04-01 00:00:00
abstract：:To determine if a physician in triage (PIT) improves Emergency Department (ED) patient flow in a community teaching hospital. This is an interventional study comparing patient flow parameters for the 3-month periods before and after implementation of a PIT model. During the interventional time an additional attending ...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-012-0839-0
更新日期：2012-10-01 00:00:00
abstract：:During the influenza season, most patients suspected of having influenza undergo rapid influenza diagnostic tests (RIDTs) in Japan despite their low sensitivity. However, the physician's actual rationale for prescribing antivirals, besides the results of RIDTs, remains poorly understood. Our study sought to identify t...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-020-02570-2
更新日期：2021-01-02 00:00:00
abstract：:Venous thromboembolism (VTE) is the third most common cardiovascular disease. Real-life data on the clinical presentation, risk factors, diagnosis, and treatment of VTE in Italy and Europe are required to optimize the management of this disease. The PREFER in VTE registry, a prospective non-interventional real-life st...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-016-1507-6
更新日期：2016-12-01 00:00:00
abstract：:Transjugular intrahepatic portosystemic shunt (TIPS) represents a very effective treatment of complications of portal hypertension. Established indications to TIPS in cirrhotic patients include portal hypertensive bleeding and refractory ascites. Over the years additional indications have been proposed, such as the tr...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-019-02252-8
更新日期：2020-01-01 00:00:00
abstract：:Up to 10% of all patients at the Emergency Department present for acute abdominal pain. The C-reactive protein (CRP) and white blood cell (WBC) are routinely determined as part of the workup of patients with abdominal pain. Three large prospective cohort studies comprising a total of 2961 adult patients with acute abd...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-015-1333-2
更新日期：2016-02-01 00:00:00
abstract：:The editorial and peer-review processes should guarantee readers as to the reliability of published data. The first step of these processes is to check for errors. The aim of our study was to look for the presence of objective errors in consecutive articles published on three of the most authoritative clinical journal...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-012-0880-z
更新日期：2013-03-01 00:00:00
abstract：:Ulcerative colitis, one of the two main forms of inflammatory bowel disease, is characterized by inflammation of the large bowel with constant involvement of the rectum, and a possible continuous retrograde distribution up to the cecum. Typical macroscopic lesions are mucosal ulcerations, with immune cell infiltration...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-011-0719-z
更新日期：2012-04-01 00:00:00
abstract：:The objective of this study is to evaluate potential drug-drug interactions (pDDIs) and risk factors for pDDIs in three phases of an acute coronary syndrome (ACS) treatment: from the point of first medical contact to the coronary angiography (first phase), after coronary angiography to the last day of hospitalization ...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-018-1994-8
更新日期：2019-04-01 00:00:00
abstract：:Inconsistent findings in the studies have been observed concerning the higher dose of statins use in the acute phase of ischemic stroke and transient ischemic attack (TIA). Therefore, we performed a systematic review to assess this issue. A computerized literature search in PubMed, Cochrane Library databases, and EMBA...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-017-1650-8
更新日期：2017-08-01 00:00:00
abstract：:The primary study objective is to compare the outcomes of patients taking oral anticoagulant medications in two distinct populations treated according to different management models (comprehensive vs. usual care). (Design: regional prospective cohort study; setting: hospital admission data from two regions). Eligible ...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-019-02148-7
更新日期：2019-11-01 00:00:00
abstract：:Use of etomidate in severe sepsis and septic shock has been challenged in recent literature due to its link to adrenal insufficiency and suspected increased mortality. We hypothesized that etomidate does not contribute to mortality in this patient population. A retrospective chart review of 230 intubated, severe sepsi...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-011-0553-3
更新日期：2011-06-01 00:00:00
abstract：:The predisposition, infection/insult, response, and organ dysfunction (PIRO) staging system for septic patients allows grouping of heterogeneous patients into homogeneous subgroups. The purposes of this single-center, prospective, observational cohort study were to create a PIRO system for patients with community-acqu...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-013-0969-z
更新日期：2013-09-01 00:00:00
abstract：:We sought to compare length-of-stay (LOS), total hospital costs, and readmissions among pulmonary embolism (PE) patients treated with rivaroxaban versus parenterally bridged warfarin. We identified adult PE (primary diagnostic code = 415.1x) patients in the Premier Database (11/2012-9/2015), and included those with ≥1...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-016-1552-1
更新日期：2017-04-01 00:00:00
abstract：:Type 1 diabetes is associated with high morbidity and mortality, mostly due to the acute and chronic complications of the disease. Restoration of the lost beta cell mass by pancreas transplantation is the treatment of choice in selected type 1 diabetic patients. Growing data show that successful pancreas transplantati...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-013-0912-3
更新日期：2013-04-01 00:00:00
abstract：:The recent position paper of the European Society of Cardiology (ESC) on cardiovascular toxicity of cancer treatments has attracted considerable interest by healthcare professionals, since it is the first concrete help in the difficult task of monitoring and approaching cardiovascular side effects of anticancer treatm...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-017-1755-0
更新日期：2018-01-01 00:00:00
abstract：:In the original publication, the given name and family name of the fifth author Dr Margherita Migone De Amicis were incorrectly published. The correct given name and family name should read as 'Margherita' and 'Migone De Amicis', respectively. ...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11739-018-1921-z
更新日期：2018-09-01 00:00:00
abstract：:Although ketamine has been used for procedural sedation and analgesia, some researchers have assessed ketamine-propofol as a better alternative because of its reduced adverse events. The goal of this review was to compare adverse events between ketamine-propofol and ketamine for procedural sedation and analgesia in ch...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s11739-019-02173-6
更新日期：2019-10-01 00:00:00
abstract：:Ethnic minority groups are disproportionately affected by cardiovascular diseases (CVDs). The reasons for the high prevalence of CVD in ethnic minority groups are not fully understood. Recently, the importance of early-life developmental factors and their impact on CVDs in adulthood is increasingly being recognised, b...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-015-1272-y
更新日期：2016-04-01 00:00:00
abstract：:Cancer patients are at risk of infectious complications due to neutropenia following chemotherapy or early post-HSCT (Hemato Stem Cell Transplantation). The first episode of fever during recent onset neutropenia is caused mostly by bacteria, while subsequent episodes are mainly fungal in nature. Proper management of i...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-010-0456-8
更新日期：2010-10-01 00:00:00
abstract：:Gut microbiota is known to have a relevant role in our health, and is also related to both gastrointestinal and extradigestive diseases. Therefore, restoring the alteration of gut microbiota represents an outstanding clinical target for the treatment of gut microbiota-related diseases. The modulation of gut microbiota...
journal_title：Internal and emergency medicine
pub_type： 杂志文章,评审
doi：10.1007/s11739-014-1069-4
更新日期：2014-06-01 00:00:00
abstract：:Direct thrombin inhibitors (DTIs) are a class of anticoagulants that bind selectively to thrombin and block its interaction with its substrates. Dabigatran etexilate and AZD0837, the new generation of DTIs, are now under intense development, and are potentially of great interest for internists. Dabigatran etexilate is...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/s11739-009-0314-8
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:Postprandial lipemia is generally studied after a test meal that provides most of the calories as fat and that does not reflect the common food intake. We investigated postprandial changes in serum triglycerides (TG) and in high-density lipoprotein (HDL) concentration and composition after a regular meal poor...
journal_title：Internal and emergency medicine
pub_type： 杂志文章
doi：10.1007/BF02934762
更新日期：2006-01-01 00:00:00
