Abstract:
:Use of etomidate in severe sepsis and septic shock has been challenged in recent literature due to its link to adrenal insufficiency and suspected increased mortality. We hypothesized that etomidate does not contribute to mortality in this patient population. A retrospective chart review of 230 intubated, severe sepsis/septic shock patients at two university tertiary care referral centers was conducted for patients receiving treatment between 12/2001 and 10/2009. The primary endpoint was in-hospital mortality. Additional investigated variables included the use of corticosteroids, hospital and intensive care unit (ICU) length of stay, mechanical ventilation days and patient demographics. One hundred seventy-three patients received etomidate and fifty-seven patients received either no medication or an alternative drug. Use of etomidate in this patient cohort did not worsen mortality. Mortality in the etomidate group was 43.9% (76/173). Mortality in the non-etomidate cohort was 45.6% (26/57) (p = 0.48). APACHE II scores were 22 ± 7.2 and 23 ± 7.1 for the etomidate group and the non-etomidate group, respectively, (p = 0.36). There was no significant difference in mortality between etomidate and non-etomidate cohorts in this study. This large retrospective multi-center study further supports the safety of etomidate use in severe sepsis and septic shock.
journal_name
Intern Emerg Medjournal_title
Internal and emergency medicineauthors
Ehrman R,Wira C,Lomax A,Hayward A,Marcelin J,Ellis T,Przyklenk K,Volturo G,Mullen Mdoi
10.1007/s11739-011-0553-3subject
Has Abstractpub_date
2011-06-01 00:00:00pages
253-7issue
3eissn
1828-0447issn
1970-9366journal_volume
6pub_type
杂志文章abstract::Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. Th...
journal_title:Internal and emergency medicine
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abstract::Diuretic resistance (DR) is common in patients with decompensated heart failure (HF), and is associated with adverse outcomes. To determine the prevalence of DR and its impact on survival among patients with decompensated HF, we prospectively evaluated the prevalence and influence on prognosis of DR (defined as persis...
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pub_type: 杂志文章,评审
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journal_title:Internal and emergency medicine
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journal_title:Internal and emergency medicine
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doi:10.1007/BF02934717
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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doi:10.1007/s11739-016-1438-2
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journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-020-02494-x
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pub_type: 杂志文章,评审
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journal_title:Internal and emergency medicine
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journal_title:Internal and emergency medicine
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journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-010-0429-y
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journal_title:Internal and emergency medicine
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journal_title:Internal and emergency medicine
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abstract::Ethnic minority groups are disproportionately affected by cardiovascular diseases (CVDs). The reasons for the high prevalence of CVD in ethnic minority groups are not fully understood. Recently, the importance of early-life developmental factors and their impact on CVDs in adulthood is increasingly being recognised, b...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
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journal_title:Internal and emergency medicine
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journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-019-02148-7
更新日期:2019-11-01 00:00:00