Abstract:
:Data on the presence of subclinical fibrosis across multiple organs in patients with idiopathic lung fibrosis (IPF) are lacking. Our study aimed at investigating through hepatic transient elastography (HTE) the prevalence and clinical impact of subclinical liver fibrosis in a cohort of patients with IPF. Patients referred to the Centre for Rare Lung Disease of the University Hospital of Modena (Italy) from March 2012 to February 2013 with established diagnosis of IPF and without a documented history of liver diseases were consecutively enrolled and underwent HTE. Based on hepatic stiffness status as assessed through METAVIR score patients were categorized as "with liver fibrosis" (corresponding to a METAVIR score of F1-F4) and "without liver fibrosis" (METAVIR F0). Potential predictors of liver fibrosis were investigated through logistic regression model among clinical and serological variables. The overall survival (OS) was assessed according to liver fibrosis and multivariate Cox regression analysis was used to identify independent predictors. In 13 out of 37 patients (35%) with IPF, a certain degree of liver fibrosis was documented. No correlation was found between liver stiffness and clinical-functional parameters. OS was lower in patients 'with liver fibrosis' than in patients 'without liver fibrosis' (median months 33 [23-55] vs. 63 [26-94], p = 0.038). Patients 'with liver fibrosis' presented a higher risk of death at seven years as compared to patients 'without liver fibrosis' (HR = 2.6, 95% CI [1.003-6.7], p = 0.049). Higher level of AST to platelet ratio index (APRI) was an independent predictor of survival (HR = 4.52 95% CI [1.3-15.6], p = 0.02). In our cohort, more than one-third of IPF patients had concomitant subclinical liver fibrosis that negatively affected OS. These preliminary claims further investigation aimed at clarifying the mechanisms beyond multiorgan fibrosis and its clinical implication in patients with IPF.
journal_name
Intern Emerg Medjournal_title
Internal and emergency medicineauthors
Cocconcelli E,Tonelli R,Abbati G,Marchioni A,Castaniere I,Pelizzaro F,Russo FP,Vegetti A,Balestro E,Pietrangelo A,Richeldi L,Luppi F,Spagnolo P,Clini E,Cerri Sdoi
10.1007/s11739-020-02376-2subject
Has Abstractpub_date
2020-05-25 00:00:00eissn
1828-0447issn
1970-9366pii
10.1007/s11739-020-02376-2pub_type
杂志文章abstract::Rapid diagnostic tools for Helicobacter pylori are important in endoscopy. To assess the accuracy of a new 5-min rapid urease test (UFT300, ABS Cernusco, sul Naviglio, Italy) compared with the 1-h Pyloritek (Serim Laboratories, Elkhart, IN) and the 24-h CLO test (Kimberly-Clark Ballard Medical Products, Roswell, GA), ...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-009-0344-2
更新日期:2010-02-01 00:00:00
abstract::The objective is to describe the characteristics of mechanically restrained patients in the emergency department (ED) of a university hospital and to evaluate the quality of restraint documentation that was filled out according to the dedicated protocol with respect to the law on restraint. All adult patients (≥16 yea...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-017-1697-6
更新日期:2018-06-01 00:00:00
abstract::Despite the availability of updated guidelines for the diagnosis and treatment of venous thromboembolism (VTE), the management of this disorder in clinical practice is often not standardized, given the different degree of compliance with official recommendations by the various involved specialists. The aim of this con...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-018-1802-5
更新日期:2018-10-01 00:00:00
abstract::The CORP (COlchicine for Recurrent Pericarditis) trial [7]is a prospective, randomized, double-blind, placebo controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in association with conventional ant...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s11739-012-0775-z
更新日期:2012-04-01 00:00:00
abstract::In heart failure survival is closely related to functional capacity. Peak O2 consumption at cardiopulmonary exercise test (CPET) is considered the gold standard for the evaluation of exercise tolerance. Since >70% of patients with heart failure, usually elderly or with significant comorbidities, are referred to Depart...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-008-0130-6
更新日期:2008-09-01 00:00:00
abstract::The authors have investigated the incidence of acute kidney injury (AKI) and short-term mortality following an activated STEMI and stroke alert at a tertiary referral and academic center. A single center, retrospective chart review of STEMI and stroke activation patients from January 2010 to March 2012. Data was colle...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-016-1407-9
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Patients with decompensated cirrhosis frequently require hospital admissions, which are associated with worse prognosis. The aim of this study was to analyze the effect of TIPS on the need for hospital care. Secondary objectives were to assess the clinical and biological impact of TIPS and to identi...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-020-02602-x
更新日期:2021-01-05 00:00:00
abstract::Non-alcoholic fatty liver disease is recognized as the most common and emerging chronic liver disease in western countries. The disease has been traditionally interpreted as a possibly progressing condition to liver fibrosis and cirrhosis. However, recently, a large number of publications have demonstrated that people...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-012-0819-4
更新日期:2012-10-01 00:00:00
abstract::Intracranial bruits (ICB) are faint, high-pitched, and mostly heard on the orbit in the systolic phase of the cardiovascular cycle. This report discusses a case of Listeria monocytogenes meningitis in a 17-month-old male patient in whom ICB were auscultated. ICB is thought to be caused by compression of blood vessels ...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-020-02579-7
更新日期:2021-01-03 00:00:00
abstract::SCODIAC was a pilot study which revealed an increasing use of SGLT2i in 123 outpatients affected with Heart Failure (HF) and Type 2 Diabetes Mellitus. SCODIAC-II study, the second phase of the program, has been carried out to determine diagnostic and therapeutic pathways in a larger group of patients and to verify whe...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-020-02528-4
更新日期:2020-10-17 00:00:00
abstract::This study aims at evaluating the prevalence of left ventricular diastolic dysfunction in a group of 319 hypertensive patients with stage 3b-4-5 chronic kidney disease (according to Kidney Disease Improving Global Outcomes classification), compared with 216 patients with essential hypertension and normal renal functio...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-019-02028-0
更新日期:2019-09-01 00:00:00
abstract::The most relevant manifestation of coronavirus disease 2019 (COVID-19) is interstitial pneumonia. Several lung ultrasound (US) protocols for pneumonia diagnosis are used in clinical practice, but none has been proposed for COVID-19 patients' screening in the emergency department. We adopted a simplified 6-scan lung US...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-020-02596-6
更新日期:2021-01-11 00:00:00
abstract::A meta-analysis to determine the impact of gender on mortality in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS): PubMed, EMBASE, and Cochrane Library, was systematically searched. Two investigators independently reviewed retrieved articles and assessed eligibility. Unadjusted mortality rat...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11739-017-1684-y
更新日期:2018-03-01 00:00:00
abstract::Extended-spectrum β-lactamase (ESBL)-producing bacteria have been spreading from hospitals to communities. Despite this, there are limited emergency department (ED) patient-based studies about these bacteremias. A retrospective matched case-control study with a ratio of 1:3 was conducted at a university hospital. The ...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-011-0707-3
更新日期:2011-12-01 00:00:00
abstract::Non-invasive ventilatory support is frequently used in patients with severe respiratory failure (SRF), but is often limited to intensive care units (ICU). We hypothesized that an instantaneous short course of NIV (up to 2 h), limited to regular working hours as an additional therapy on the emergency department (ED) wo...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-016-1546-z
更新日期:2017-12-01 00:00:00
abstract::Diuretic resistance (DR) is common in patients with decompensated heart failure (HF), and is associated with adverse outcomes. To determine the prevalence of DR and its impact on survival among patients with decompensated HF, we prospectively evaluated the prevalence and influence on prognosis of DR (defined as persis...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-018-02019-7
更新日期:2019-06-01 00:00:00
abstract::The high cardiovascular risk burden in low- and middle-income countries is expected to lead to an explosive increase in chronic kidney disease (CKD). However, population data on CKD from these countries are scarce. Therefore, we assessed kidney health in Suriname. In the Healthy Life in Suriname (HeliSur) study, a ran...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-018-1962-3
更新日期:2019-03-01 00:00:00
abstract::The idea of using small RNA fragments (oligonucleotides) for therapeutic purposes dates back to the 1990s, following the landmark discoveries on the mechanisms of gene silencing and RNA-interference (RNA-i). However, the first applications in medicine were hampered by difficulties in chemical stabilization and efficie...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-018-1810-5
更新日期:2018-04-01 00:00:00
abstract::Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. Th...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11739-018-1833-y
更新日期:2018-08-01 00:00:00
abstract::General concepts about medical disasters, public health and triage are outlined. Triage is described in the context of public health emergencies and disaster settings, and the main ethical values at stake in triage are discussed. Possible conflicts between competing values are outlined. Special attention is given to p...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-010-0362-0
更新日期:2010-04-01 00:00:00
abstract::Objective measurement of simulation performance requires a validated and reliable tool. However, no published Italian language assessment tool is available. Translation of a published English language tool, the Ottawa Crisis Resource Management Global Rating Scale (GRS), may lead to a validated and reliable tool. Afte...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-016-1486-7
更新日期:2017-08-01 00:00:00
abstract::In chronic heart failure (CHF), neurohumoral systems, which help to maintain circulatory homeostasis, are maladaptive and responsible for disease progression and congestion in the long term. The activation of sympathetic hormones and renin-angiotensin-aldosterone system (RAAS), in addition to non-osmotic vasopressin r...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-011-0674-8
更新日期:2011-10-01 00:00:00
abstract::Genetic and acquired motor-neuron-disorders (MNDs) may undergo acute deterioration resulting in various emergency situations. This literature review aims at summarising and discussing current knowledge about emergencies in MNDs. Emergencies that have been reported in MND patients include: respiratory, bulbar, cardiac,...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-017-1644-6
更新日期:2017-08-01 00:00:00
abstract::The primary study objective is to compare the outcomes of patients taking oral anticoagulant medications in two distinct populations treated according to different management models (comprehensive vs. usual care). (Design: regional prospective cohort study; setting: hospital admission data from two regions). Eligible ...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-019-02148-7
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:In marathon runners changes in red blood cell count, haematocrit and haemoglobin in relation to haemodilution have been reported. Moreover, it has been hypothesized that strenuous exercise induces oxidant stress through several different mechanisms. This study investigated the haematological variables, iron s...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/BF02934717
更新日期:2006-01-01 00:00:00
abstract::Splanchnic vein thrombosis (SVT) is a possible complication of acute pancreatitis (AP). There are no precise guidelines on the use of anticoagulant therapy (AT) in these patients. The aim of the study was to determine the safety and the efficacy of AT in AP-associated SVT. Two hundred twenty-one patients were retrospe...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-019-02271-5
更新日期:2020-09-01 00:00:00
abstract::Anthracyclines are extensively used in oncologic patients, in particular for breast cancer and hematological malignancies. Cardiac injury is a potentially dangerous side effect of these drugs. In this systematic review, we analyzed published randomized controlled trials (RCTs) to assess if potential cardioprotective d...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-020-02508-8
更新日期:2020-10-03 00:00:00
abstract::Endometriosis is a common condition characterized by proliferation of endometrial tissue outside the uterus, both in the pelvis and in other extra-pelvic sites. The clinical picture of endometriosis is widely heterogeneous. A correct diagnostic work-up of these patients can sometimes be very difficult, since there are...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-010-0404-7
更新日期:2010-12-01 00:00:00
abstract::During the influenza season, most patients suspected of having influenza undergo rapid influenza diagnostic tests (RIDTs) in Japan despite their low sensitivity. However, the physician's actual rationale for prescribing antivirals, besides the results of RIDTs, remains poorly understood. Our study sought to identify t...
journal_title:Internal and emergency medicine
pub_type: 杂志文章
doi:10.1007/s11739-020-02570-2
更新日期:2021-01-02 00:00:00
abstract::Recurrent pericarditis is one of the most frequent pericardial diseases, affecting up to 30% of the patients who have experienced acute pericarditis. While the diagnosis of acute pericarditis is sometime straight forward, its etiology and therapeutic management are still a challenge for physicians. In developed countr...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-018-1842-x
更新日期:2018-06-01 00:00:00