Colchicine is safe and effective for secondary prevention of recurrent pericarditis.

Abstract:

:The CORP (COlchicine for Recurrent Pericarditis) trial [7]is a prospective, randomized, double-blind, placebo controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in association with conventional anti-inflammatory therapy for the secondary prevention of recurrence in patients with a first relapse of pericarditis. Patients were excluded if they were having their first episode of acute pericarditis, or their second or subsequent recurrence, or had pericarditis with tuberculous, purulent, or neoplastic causes. The primary study end point was the recurrence rate at 18 months. Secondary end points were symptom persistence after 72 h, remission rate at 1 week, number of recurrences, time to first recurrence, disease-related hospitalizations,cardiac tamponade, and constrictive pericarditis rates.120 patients (60 in the colchicine and 60 in the placebo group) were included in the analysis. The recurrence rate is 24 % in the colchicine group and 55 % in the placebo group (absolute risk reduction 0.31 [95 % CI 0.13–0.46];relative risk reduction 0.56 [0.27–0.73]; number needed to treat 3 [2–7]). Colchicine improves the persistence of symptoms at 72 h (absolute risk reduction 0.30 [95 % IC,0.13–0.45]; relative risk reduction 0.56 [0.27–0.74]). It also reduces the mean number of recurrences, increases the remission rate at 1 week and prolongs the time to subsequent recurrence. Colchicine and placebo groups have similar rates of side effects (7 %) and drug withdrawal (8 vs. 5 %, P = 0.89);no severe side effects occurred in any of the groups. Gastrointestinal intolerance was the main side effect during the study.

journal_name

Intern Emerg Med

authors

Gianni F,Solbiati M,Gruppo di Autoformazione Metodologica (GrAM).

doi

10.1007/s11739-012-0775-z

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

181-2

issue

2

eissn

1828-0447

issn

1970-9366

journal_volume

7

pub_type

杂志文章,多中心研究,随机对照试验
  • Overcrowding in emergency department: an international issue.

    abstract::Overcrowding in the emergency department (ED) has become an increasingly significant worldwide public health problem in the last decade. It is a consequence of simultaneous increasing demand for health care and a deficit in available hospital beds and ED beds, as for example it occurs in mass casualty incidents, but a...

    journal_title:Internal and emergency medicine

    pub_type: 社论

    doi:10.1007/s11739-014-1154-8

    authors: Di Somma S,Paladino L,Vaughan L,Lalle I,Magrini L,Magnanti M

    更新日期:2015-03-01 00:00:00

  • A comparison between time to clinical stability in community-acquired aspiration pneumonia and community-acquired pneumonia.

    abstract::Antimicrobial therapy has been the main stay of therapy of community-acquired aspiration pneumonia (CAAP), but the duration of treatment has not been established. The objective of this study was to describe the time to reach clinical stability in patients with aspiration pneumonia compared to community-acquired pneumo...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-012-0764-2

    authors: Jaoude P,Badlam J,Anandam A,El-Solh AA

    更新日期:2014-03-01 00:00:00

  • The perception of health-related quality of life in colon cancer patients during chemotherapy: differences between men and women.

    abstract::There is a need for more information on the quality of life (QoL) in patients undergoing chemotherapy. We wanted to investigate the perception of health status in colon cancer patients before, 3 and 6 months after chemotherapy. A secondary purpose was to assess the different perceptions of QoL between men and women du...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-014-1174-4

    authors: Domati F,Luppi G,Reggiani-Bonetti L,Zironi S,Depenni R,Fontana A,Gelsomino F,de Leon MP

    更新日期:2015-06-01 00:00:00

  • Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients.

    abstract::Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper endoscopy for dyspe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-015-1218-4

    authors: Dore MP,Marras G,Rocchi C,Soro S,Loria MF,Bassotti G,Graham DY,Malaty HM,Pes GM

    更新日期:2015-10-01 00:00:00

  • Failure to achieve first attempt success at intubation using video laryngoscopy is associated with increased complications.

    abstract::The purpose of this investigation was to investigate the association between first attempt success and intubation-related complications in the Intensive Care Unit after the widespread adoption of video laryngoscopy. We further sought to characterize and identify the predictors of complications that occur despite first...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1549-9

    authors: Hypes C,Sakles J,Joshi R,Greenberg J,Natt B,Malo J,Bloom J,Chopra H,Mosier J

    更新日期:2017-12-01 00:00:00

  • Cardiometabolic risk prevention strategies: the importance of sharing experiences between Mediterranean countries.

    abstract::According to the Global Burden of Disease Study 2017, between 1990 and 2017, Italy experienced a more attenuate reduction in cardiovascular deaths than Western Europe. When considering risk factors, our Country experienced a reduction in the prevalence of hypertension in the last few decades, especially in women. On t...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-019-02263-5

    authors: Modesti PA,Jarraya F,Mascherini G,Perticone F

    更新日期:2020-06-01 00:00:00

  • Subclinical hyperthyroidism and cardiovascular manifestations: a reevaluation of the association.

    abstract::Subclinical hyperthyroidism (SH) has been reported associated with atrial fibrillation (AF), heart failure (HF) and coronary heart disease events, including mortality. An expert opinion indicates that AF is the possible link between SH and the other important cardiovascular (CV) manifestations. We analyzed the data of...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-013-0913-2

    authors: Carpi A,Cini G,Russo M,Antonelli A,Gaudio C,Galetta F,Franzoni F,Rossi G

    更新日期:2013-04-01 00:00:00

  • Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding.

    abstract::Hypertension and diabetes are known risk factors for obesity-related thrombosis, but several studies have shown that obesity is characterised by a potentially prothrombotic inflammatory state because of activated coagulation and impaired fibrinolysis. In order to verify if obese patients-unaffected by hypertension, di...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0522-x

    authors: Cugno M,Castelli R,Mari D,Mozzi E,Zappa MA,Boscolo-Anzoletti M,Roviaro G,Mannucci PM

    更新日期:2012-06-01 00:00:00

  • Prevalence and prognostic impact of left ventricular non-compaction in patients with thalassemia.

    abstract::A high incidence of isolated left ventricular non-compaction (LVNC) has been reported in previous studies on smaller cohorts of patients with thalassemia by cardiac MRI but the clinical impact of the finding is unknown. This prospective cohort study evaluates the prevalence and clinical implication of the finding. Pro...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-019-02114-3

    authors: Bonamini R,Imazio M,Faletti R,Gatti M,Xhyheri B,Limone M,Longo F,Piga A

    更新日期:2019-11-01 00:00:00

  • E-cigarette use is strongly associated with recent smoking cessation: an analysis of a representative population sample in Greece.

    abstract::The purpose was to examine the association between e-cigarette use and smoking cessation according to quit duration in Greece in 2017. A cross-sectional survey of a representative sample of adults living in Attica prefecture was performed in May 2017 through telephone interviews. The present analysis was confined to c...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-02023-x

    authors: Farsalinos K,Siakas G,Poulas K,Voudris V,Merakou K,Barbouni A

    更新日期:2019-09-01 00:00:00

  • NIV by an interdisciplinary respiratory care team in severe respiratory failure in the emergency department limited to day time hours.

    abstract::Non-invasive ventilatory support is frequently used in patients with severe respiratory failure (SRF), but is often limited to intensive care units (ICU). We hypothesized that an instantaneous short course of NIV (up to 2 h), limited to regular working hours as an additional therapy on the emergency department (ED) wo...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1546-z

    authors: Horvath CM,Brutsche MH,Schoch OD,Schillig B,Baty F,vonOw D,Rüdiger JJ

    更新日期:2017-12-01 00:00:00

  • Antimicrobial stewardship in an Internal Medicine ward: effects on antibiotic consumption and on the use of carbapenems.

    abstract::Assessing the effects of an antimicrobial stewardship program (ASP) implemented in a 78-bed Internal Medicine ward of an Italian mid-sized acute care hospital of 296 beds (26,820 bed days/year in 2015 and 26,653 in 2016). The ASP, implemented in May 2016, included: (a) formulation and dissemination of local guidelines...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1916-9

    authors: Fortini A,Faraone A,Di Pietro M,Cappugi C,Magnante G,Boccadori C,Bartolini S,Rabatti L

    更新日期:2018-12-01 00:00:00

  • Emergencies in motoneuron disease.

    abstract::Genetic and acquired motor-neuron-disorders (MNDs) may undergo acute deterioration resulting in various emergency situations. This literature review aims at summarising and discussing current knowledge about emergencies in MNDs. Emergencies that have been reported in MND patients include: respiratory, bulbar, cardiac,...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-017-1644-6

    authors: Finsterer J,Stöllberger C

    更新日期:2017-08-01 00:00:00

  • Right ventricular function predicts cardiovascular events in outpatients with stable cardiovascular diseases: preliminary results.

    abstract::Right ventricular (RV) function impacts the outcome in cardiac and pulmonary diseases such as heart failure, pulmonary hypertension, myocardial infarction, valvular, and congenital heart diseases. To our knowledge, simultaneous evaluation of left ventricular (LV) and RV systolic and diastolic echocardiographic indices...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0508-8

    authors: Giovanardi P,Tincani E,Rossi R,Agnoletto V,Bondi M,Modena MG

    更新日期:2012-06-01 00:00:00

  • Usefulness of procalcitonin level as an outcome predictor of adult bacterial meningitis.

    abstract::Acute bacterial meningitis is rare, but can be fulminant unless rapidly evaluated and treated. The aim of this study was to evaluate whether serum procalcitonin (PCT) levels could predict unfavorable outcomes of bacterial meningitis. We retrospectively reviewed the medical records of 604 meningitis patients from the e...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1509-4

    authors: Ko BS,Ryoo SM,Ahn S,Sohn CH,Seo DW,Kim WY

    更新日期:2017-10-01 00:00:00

  • Prevalence and 1-year prognosis of transient heart failure following coronary revascularization.

    abstract::The occurrence of heart failure during the whole pre-discharge course of coronary revascularization, as far as its influence on subsequent prognosis, is poorly understood. The present study examined the effect of transient heart failure (THF) developing in the acute and rehabilitative phase on survival after coronary ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11739-013-1006-y

    authors: Ambrosetti M,Griffo R,Tramarin R,Fattirolli F,Temporelli PL,Faggiano P,De Feo S,Vestri AR,Giallauria F,Greco C

    更新日期:2014-09-01 00:00:00

  • Physician in triage improves emergency department patient throughput.

    abstract::To determine if a physician in triage (PIT) improves Emergency Department (ED) patient flow in a community teaching hospital. This is an interventional study comparing patient flow parameters for the 3-month periods before and after implementation of a PIT model. During the interventional time an additional attending ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-012-0839-0

    authors: Imperato J,Morris DS,Binder D,Fischer C,Patrick J,Sanchez LD,Setnik G

    更新日期:2012-10-01 00:00:00

  • The effect of body mass index on intubation success rates and complications during emergency airway management.

    abstract::We evaluated the effect of body mass index (BMI) on intubation success rates and complications during emergency airway management. We retrospectively analyzed an airway registry at an academic medical center. The primary outcomes were the incidence of difficult intubation and complication rates, stratified by BMI. We ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-012-0874-x

    authors: Dargin JM,Emlet LL,Guyette FX

    更新日期:2013-02-01 00:00:00

  • Endometriosis, need for a multidisciplinary clinical setting: the internist's point of view.

    abstract::Endometriosis is a common condition characterized by proliferation of endometrial tissue outside the uterus, both in the pelvis and in other extra-pelvic sites. The clinical picture of endometriosis is widely heterogeneous. A correct diagnostic work-up of these patients can sometimes be very difficult, since there are...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-010-0404-7

    authors: Montalto M,Santoro L,D'Onofrio F,Gallo A,Campo S,Campo V,Gasbarrini A,Gasbarrini G

    更新日期:2010-12-01 00:00:00

  • Cardiovascular oncology: a new discipline inside internal medicine?

    abstract::Cardiovascular disease and cancer incidence and prevalence have risen over the past few decades to become the leading causes of death. On the one hand, cancer patients will be treated with cardiotoxic chemotherapies; on the other, cardiovascular patients will receive a new diagnosis of cancer and will have to face tre...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-014-1064-9

    authors: Prisco D,D'Elios MM,Cenci C,Ciucciarelli L,Tamburini C

    更新日期:2014-06-01 00:00:00

  • Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh-frozen plasma.

    abstract::Cirrhosis is characterized by a complex coagulation defect leading to the prolongation of the prothrombin and activated partial thromboplastin times (PT and APTT). Arbitrary PT cut-off values are still used as a yardstick to guide treatment with fresh-frozen plasma (FFP) or other pro-coagulant agents in patients under...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0528-4

    authors: Tripodi A,Chantarangkul V,Primignani M,Clerici M,Dell'era A,Aghemo A,Mannucci PM

    更新日期:2012-04-01 00:00:00

  • Association between in-hospital acute hypertensive episodes and outcomes in older trauma patients.

    abstract::Although chronic hypertension is associated with long-term complications, few studies directly examine the effects of in-hospital acute hypertensive episodes in trauma patients. The aim was to determine whether there is an association between in-hospital acute hypertension and morbidity. We included trauma patients be...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-013-0984-0

    authors: Saliba L,Stawicki SP,Thongrong C,Bergese SD,Papadimos TJ,Gerlach AT

    更新日期:2014-08-01 00:00:00

  • Variations in clinical management of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation according to different equations for estimating renal function : Post hoc analysis of a prospective cohort.

    abstract::Prescription of non-vitamin K antagonist oral anticoagulants (NOACs) requires an assessment of renal function (RF) and the Cockcroft-Gault (CG) equation is traditionally recommended. The objective of the study was to evaluate the potential changes in NOACs management using different equations for estimating RF. In a p...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1857-3

    authors: Malavasi VL,Pettorelli D,Fantecchi E,Zoccali C,Laronga G,Trenti T,Lip GYH,Boriani G

    更新日期:2018-10-01 00:00:00

  • Gut microbiota modulation: probiotics, antibiotics or fecal microbiota transplantation?

    abstract::Gut microbiota is known to have a relevant role in our health, and is also related to both gastrointestinal and extradigestive diseases. Therefore, restoring the alteration of gut microbiota represents an outstanding clinical target for the treatment of gut microbiota-related diseases. The modulation of gut microbiota...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-014-1069-4

    authors: Cammarota G,Ianiro G,Bibbò S,Gasbarrini A

    更新日期:2014-06-01 00:00:00

  • Which method is best for an early accurate diagnosis of acute heart failure? Comparison between lung ultrasound, chest X-ray and NT pro-BNP performance: a prospective study.

    abstract::Acute heart failure is a common condition among adults presenting with dyspnea in the Emergency Department (ED), still the diagnosis is challenging as objective standardized criteria are lacking. First line work-up, other then clinical findings, is nowadays made with lung ultrasound imaging study, chest X-ray study an...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1498-3

    authors: Sartini S,Frizzi J,Borselli M,Sarcoli E,Granai C,Gialli V,Cevenini G,Guazzi G,Bruni F,Gonnelli S,Pastorelli M

    更新日期:2017-09-01 00:00:00

  • Can haemostatic factors predict atherothrombosis?

    abstract::Thrombosis is "haemostasis in the wrong place", and there is increasing evidence that haemostatic factors are associated with increased risk of atherothrombotic events. Increasing plasma levels of fibrinogen are associated with increased risks of coronary heart disease, stroke and peripheral arterial disease, and with...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11739-011-0536-4

    authors: Lowe G

    更新日期:2011-12-01 00:00:00

  • Quality of life impairment in Behçet's disease and relationship with disease activity: a prospective study.

    abstract::Our aim was to prospectively investigate the impact of Behçet's disease (BD), disease activity, and clinical and demographic characteristics on different aspects of quality of life (QoL) measured by the short-form (SF)-36 QoL scale. We administered the SF-36 to 37 consecutive BD patients in different moments of diseas...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-017-1691-z

    authors: Fabiani C,Vitale A,Orlando I,Sota J,Capozzoli M,Franceschini R,Galeazzi M,Tosi GM,Frediani B,Cantarini L

    更新日期:2017-10-01 00:00:00

  • An Italian version of the Ottawa Crisis Resource Management Global Rating Scale: a reliable and valid tool for assessment of simulation performance.

    abstract::Objective measurement of simulation performance requires a validated and reliable tool. However, no published Italian language assessment tool is available. Translation of a published English language tool, the Ottawa Crisis Resource Management Global Rating Scale (GRS), may lead to a validated and reliable tool. Afte...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1486-7

    authors: Franc JM,Verde M,Gallardo AR,Carenzo L,Ingrassia PL

    更新日期:2017-08-01 00:00:00

  • The incidence and significance of acute kidney injury following emergent contrast administration in patients with STEMI and stroke.

    abstract::The authors have investigated the incidence of acute kidney injury (AKI) and short-term mortality following an activated STEMI and stroke alert at a tertiary referral and academic center. A single center, retrospective chart review of STEMI and stroke activation patients from January 2010 to March 2012. Data was colle...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1407-9

    authors: Marchick MR,Allen BR,Weeks EC,Shuster JJ,Elie MC

    更新日期:2016-09-01 00:00:00

  • Non-alcoholic fatty liver disease and cardiovascular disease: epidemiological, clinical and pathophysiological evidences.

    abstract::Non-alcoholic fatty liver disease is recognized as the most common and emerging chronic liver disease in western countries. The disease has been traditionally interpreted as a possibly progressing condition to liver fibrosis and cirrhosis. However, recently, a large number of publications have demonstrated that people...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-012-0819-4

    authors: Del Ben M,Baratta F,Polimeni L,Angelico F

    更新日期:2012-10-01 00:00:00