Prevention of anthracycline-induced cardiotoxicity: a systematic review and meta-analysis.

Abstract:

:Anthracyclines are extensively used in oncologic patients, in particular for breast cancer and hematological malignancies. Cardiac injury is a potentially dangerous side effect of these drugs. In this systematic review, we analyzed published randomized controlled trials (RCTs) to assess if potential cardioprotective drugs (i.e., renin-angiotensin-aldosterone system [RAAS] blockers and β-blockers) may prevent heart damage by anthracyclines. Studies were identified by electronic search of MEDLINE and EMBASE database until August 2020. The impact of cardioprotective drugs to prevent anthracyclines-induced cardiac injury was expressed as mean difference (MD) or odds ratio (OR) and 95% confidence intervals (95% CI). Statistical heterogeneity was assessed with the I2 statistic. Twelve RCTs for a total of 1.035 cancer patients treated with anthracyclines were included. RAAS blockers, β-blockers, and aldosterone antagonists showed a statistically significant benefit in preventing left ventricular ejection fraction (LVEF) reduction (MD 3.57, 95% CI 1.04, 6.09) in 11 studies. A non-statistically significant difference was observed in preventing E/A velocity decrease (MD 0.09, 95% CI 0.00, 0.17; 9 studies), left ventricular end-systolic diameter (LVESD) increase (MD - 0.88, 95% CI, - 2.75,0.99; 6 studies), left ventricular end-diastolic diameter (LVEDD) increase (MD -0.95, 95% CI - 2.67,0.76; 6 studies), and mitral A velocity decrease (MD - 1.42, 95% CI - 3.01,0.17; 4 studies). Heart failure was non-significantly reduced in the cardioprotective arm (OR 0.31, 95% CI 0.06, 1.59; 5 studies). Hypotension was non-significantly increased in the cardioprotective arm (OR 3.91, 95% CI 0.42, 36.46, 3 studies). Cardioprotective drugs reduce anthracycline-induced cardiac damage as assessed by echocardiographic parameters. The clinical relevance of this positive effect is still to be defined.

journal_name

Intern Emerg Med

authors

Caspani F,Tralongo AC,Campiotti L,Asteggiano R,Guasti L,Squizzato A

doi

10.1007/s11739-020-02508-8

subject

Has Abstract

pub_date

2020-10-03 00:00:00

eissn

1828-0447

issn

1970-9366

pii

10.1007/s11739-020-02508-8

pub_type

杂志文章,评审
  • Anticoagulant therapy in the treatment of splanchnic vein thrombosis associated to acute pancreatitis: a 3-year single-centre experience.

    abstract::Splanchnic vein thrombosis (SVT) is a possible complication of acute pancreatitis (AP). There are no precise guidelines on the use of anticoagulant therapy (AT) in these patients. The aim of the study was to determine the safety and the efficacy of AT in AP-associated SVT. Two hundred twenty-one patients were retrospe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-019-02271-5

    authors: Pagliari D,Cianci R,Brizi MG,Mancarella FA,Musso M,Cintoni M,Franza L,Flore RA,Gasbarrini A,Tondi P

    更新日期:2020-09-01 00:00:00

  • An Italian version of the Ottawa Crisis Resource Management Global Rating Scale: a reliable and valid tool for assessment of simulation performance.

    abstract::Objective measurement of simulation performance requires a validated and reliable tool. However, no published Italian language assessment tool is available. Translation of a published English language tool, the Ottawa Crisis Resource Management Global Rating Scale (GRS), may lead to a validated and reliable tool. Afte...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1486-7

    authors: Franc JM,Verde M,Gallardo AR,Carenzo L,Ingrassia PL

    更新日期:2017-08-01 00:00:00

  • Prevalence and 1-year prognosis of transient heart failure following coronary revascularization.

    abstract::The occurrence of heart failure during the whole pre-discharge course of coronary revascularization, as far as its influence on subsequent prognosis, is poorly understood. The present study examined the effect of transient heart failure (THF) developing in the acute and rehabilitative phase on survival after coronary ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11739-013-1006-y

    authors: Ambrosetti M,Griffo R,Tramarin R,Fattirolli F,Temporelli PL,Faggiano P,De Feo S,Vestri AR,Giallauria F,Greco C

    更新日期:2014-09-01 00:00:00

  • Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes.

    abstract::Type 1 diabetes is associated with high morbidity and mortality, mostly due to the acute and chronic complications of the disease. Restoration of the lost beta cell mass by pancreas transplantation is the treatment of choice in selected type 1 diabetic patients. Growing data show that successful pancreas transplantati...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-013-0912-3

    authors: Marchetti P,Occhipinti M,Rondinini L,Mariotti R,Amorese G,Barsotti M,Vistoli F,Boggi U

    更新日期:2013-04-01 00:00:00

  • Non-alcoholic fatty liver disease and cardiovascular disease: epidemiological, clinical and pathophysiological evidences.

    abstract::Non-alcoholic fatty liver disease is recognized as the most common and emerging chronic liver disease in western countries. The disease has been traditionally interpreted as a possibly progressing condition to liver fibrosis and cirrhosis. However, recently, a large number of publications have demonstrated that people...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-012-0819-4

    authors: Del Ben M,Baratta F,Polimeni L,Angelico F

    更新日期:2012-10-01 00:00:00

  • Upper extremity deep vein thrombosis.

    abstract::Upper extremities deep venous thrombosis (UEDVT) is a rare condition. According to the literature, approximately 4-10% of all cases of venous thrombosis may involve the subclavian, axillary or brachial veins. In the last few decades, the incidence of UEDVT has increased because of more frequent use of central venous c...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-009-0320-x

    authors: Spiezia L,Simioni P

    更新日期:2010-04-01 00:00:00

  • Diagnosis and management of acute aortic syndromes in the emergency department.

    abstract::Acute aortic syndromes (AASs) are deadly cardiovascular emergencies involving the thoracic aorta. AASs are relatively rare conditions, have unspecific signs and symptoms (including truncal pain, syncope, neurologic deficit and limb ischemia) and require contrast-enhanced tomography angiography (CTA) of the chest and a...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-020-02354-8

    authors: Morello F,Santoro M,Fargion AT,Grifoni S,Nazerian P

    更新日期:2021-01-01 00:00:00

  • Evaluation of community-acquired sepsis by PIRO system in the emergency department.

    abstract::The predisposition, infection/insult, response, and organ dysfunction (PIRO) staging system for septic patients allows grouping of heterogeneous patients into homogeneous subgroups. The purposes of this single-center, prospective, observational cohort study were to create a PIRO system for patients with community-acqu...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-013-0969-z

    authors: Chen YX,Li CS

    更新日期:2013-09-01 00:00:00

  • New direct thrombin inhibitors.

    abstract::Direct thrombin inhibitors (DTIs) are a class of anticoagulants that bind selectively to thrombin and block its interaction with its substrates. Dabigatran etexilate and AZD0837, the new generation of DTIs, are now under intense development, and are potentially of great interest for internists. Dabigatran etexilate is...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-009-0314-8

    authors: Squizzato A,Dentali F,Steidl L,Ageno W

    更新日期:2009-12-01 00:00:00

  • Bedside ultrasonography (US), Echoscopy and US point of care as a new kind of stethoscope for Internal Medicine Departments: the training program of the Italian Internal Medicine Society (SIMI).

    abstract::In recent years, thanks to the development of miniaturized ultrasound devices, comparable to personal computers, tablets and even to smart phones, we have seen an increasing use of bedside ultrasound in internal medicine departments as a novel kind of ultrasound stethoscope. The clinical ultrasound-assisted approach h...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-014-1113-4

    authors: Arienti V,Di Giulio R,Cogliati C,Accogli E,Aluigi L,Corazza GR,Ultrasound SIMI Study Group.

    更新日期:2014-10-01 00:00:00

  • Variations in clinical management of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation according to different equations for estimating renal function : Post hoc analysis of a prospective cohort.

    abstract::Prescription of non-vitamin K antagonist oral anticoagulants (NOACs) requires an assessment of renal function (RF) and the Cockcroft-Gault (CG) equation is traditionally recommended. The objective of the study was to evaluate the potential changes in NOACs management using different equations for estimating RF. In a p...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1857-3

    authors: Malavasi VL,Pettorelli D,Fantecchi E,Zoccali C,Laronga G,Trenti T,Lip GYH,Boriani G

    更新日期:2018-10-01 00:00:00

  • An attempt to measure the spread of emergency medicine internationally.

    abstract:OBJECTIVE:To determine the feasibility of using the internet to track the spread of emergency medicine internationally. METHODS: OVERVIEW:This was an attempt to perform a descriptive cross-sectional study employing a web-based survey. SUBJECTS:Potential respondents were identified from multiple sources. OBSERVATION...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-007-0083-1

    authors: Nagurney JT,Huang C,Kulkarni RG,Sane S,Davis MA,Anderson PD,Gaufberg SV,Ciottone GR,Motola I,Chang Y,Setnik G

    更新日期:2007-12-01 00:00:00

  • Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients.

    abstract::Auto-titrating noninvasive ventilation (NIV) has been developed as a new mode applying variable expiratory-positive airway pressure (EPAP) in addition to variable inspiratory pressures (IPAP), both to deliver targeted tidal volume (VT) and to eliminate upper airway resistance. The purpose of this study is to evaluate ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1821-2

    authors: Gursel G,Zerman A,Basarik B,Gonderen K,Aydogdu M,Memmedova S

    更新日期:2018-04-01 00:00:00

  • Colchicine is safe and effective for secondary prevention of recurrent pericarditis.

    abstract::The CORP (COlchicine for Recurrent Pericarditis) trial [7]is a prospective, randomized, double-blind, placebo controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in association with conventional ant...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s11739-012-0775-z

    authors: Gianni F,Solbiati M,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2012-04-01 00:00:00

  • Supraglottic jet oxygenation and ventilation-assisted fibre-optic bronchoscope intubation in patients with difficult airways.

    abstract::A difficult airway may lead to hypoxia and brain damage. The WEI Nasal Jet Tube (WNJ) is a new nasal pharyngeal tube that applies supraglottic jet oxygenation and ventilation (SJOV) for patients during tracheal intubation without the need for mask ventilation. We evaluated the effectiveness and safety of SJOV-assisted...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1531-6

    authors: Wu C,Wei J,Cen Q,Sha X,Cai Q,Ma W,Cao Y

    更新日期:2017-08-01 00:00:00

  • Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience.

    abstract::The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0619-2

    authors: Valente S,Lazzeri C,Chiostri M,Alterini B,Ognibene A,Giglioli C,Pigozzi C,Gensini GF

    更新日期:2013-06-01 00:00:00

  • Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding.

    abstract::Hypertension and diabetes are known risk factors for obesity-related thrombosis, but several studies have shown that obesity is characterised by a potentially prothrombotic inflammatory state because of activated coagulation and impaired fibrinolysis. In order to verify if obese patients-unaffected by hypertension, di...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0522-x

    authors: Cugno M,Castelli R,Mari D,Mozzi E,Zappa MA,Boscolo-Anzoletti M,Roviaro G,Mannucci PM

    更新日期:2012-06-01 00:00:00

  • Antimicrobial stewardship in an Internal Medicine ward: effects on antibiotic consumption and on the use of carbapenems.

    abstract::Assessing the effects of an antimicrobial stewardship program (ASP) implemented in a 78-bed Internal Medicine ward of an Italian mid-sized acute care hospital of 296 beds (26,820 bed days/year in 2015 and 26,653 in 2016). The ASP, implemented in May 2016, included: (a) formulation and dissemination of local guidelines...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1916-9

    authors: Fortini A,Faraone A,Di Pietro M,Cappugi C,Magnante G,Boccadori C,Bartolini S,Rabatti L

    更新日期:2018-12-01 00:00:00

  • Echocardiographic assessment of the right ventricle in COVID -related acute respiratory syndrome.

    abstract::In patients with the novel coronavirus (COVID-19) infection, the echocardiographic assessment of the right ventricle (RV) represents a pivotal element in the understanding of current disease status and in monitoring disease progression. The present manuscript is aimed at specifically describing the echocardiographic a...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02494-x

    authors: Lazzeri C,Bonizzoli M,Batacchi S,Peris A

    更新日期:2021-01-01 00:00:00

  • Brain natriuretic peptide as a preclinical marker of chronic pulmonary hypertension in patients with pulmonary embolism.

    abstract::Chronic thromboembolic pulmonary hypertension (CTPH) is a potential complication of pulmonary embolism (PE). Only few studies have assessed the role of brain natriuretic peptide (BNP) in patients with chronic pulmonary hypertension, and there are no data on the potential utility of BNP as a preclinical biomarker of CT...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-009-0231-x

    authors: Dentali F,Donadini M,Gianni M,Bertolini A,Lonn E,Venco A,Cattozzo G,Ageno W

    更新日期:2009-04-01 00:00:00

  • Can haemostatic factors predict atherothrombosis?

    abstract::Thrombosis is "haemostasis in the wrong place", and there is increasing evidence that haemostatic factors are associated with increased risk of atherothrombotic events. Increasing plasma levels of fibrinogen are associated with increased risks of coronary heart disease, stroke and peripheral arterial disease, and with...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11739-011-0536-4

    authors: Lowe G

    更新日期:2011-12-01 00:00:00

  • Survival protection by bodyweight in isolated scleroderma-related pulmonary artery hypertension.

    abstract::In chronic heart failure (CHF) due to systemic cardiovascular disease, obese patients have better survival. Bodyweight versus survival was analyzed post hoc in subjects with limited scleroderma (SSc) and isolated pulmonary artery hypertension (PAH), i.e. with CHF due to pulmonary vascular disease. Rheumatologists refe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1446-2

    authors: Marini C,Formichi B,Bauleo C,Michelassi C,Airò E,Rossi G,Giuntini C

    更新日期:2016-10-01 00:00:00

  • Infliximab-related hepatitis: discussion of a case and review of the literature.

    abstract::Despite its rarity, infliximab-related hepatitis constitutes a cutting edge and challenging problem. In December 2004, a drug warning was issued by the Food and Drug Administration to alert healthcare professionals to the risk of hepatotoxicity in course of infliximab therapy. Subsequently, several reports of probable...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-009-0342-4

    authors: Mancini S,Amorotti E,Vecchio S,Ponz de Leon M,Roncucci L

    更新日期:2010-06-01 00:00:00

  • Multidisciplinary approach to the management of patients with pulmonary embolism and deep vein thrombosis: a consensus on diagnosis, traditional therapy and therapy with rivaroxaban.

    abstract::Despite the availability of updated guidelines for the diagnosis and treatment of venous thromboembolism (VTE), the management of this disorder in clinical practice is often not standardized, given the different degree of compliance with official recommendations by the various involved specialists. The aim of this con...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1802-5

    authors: Imberti D,Becattini C,Bernardi E,Camporese G,Cuccia C,Dentali F,Paretti D

    更新日期:2018-10-01 00:00:00

  • The incidence and significance of acute kidney injury following emergent contrast administration in patients with STEMI and stroke.

    abstract::The authors have investigated the incidence of acute kidney injury (AKI) and short-term mortality following an activated STEMI and stroke alert at a tertiary referral and academic center. A single center, retrospective chart review of STEMI and stroke activation patients from January 2010 to March 2012. Data was colle...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1407-9

    authors: Marchick MR,Allen BR,Weeks EC,Shuster JJ,Elie MC

    更新日期:2016-09-01 00:00:00

  • Splanchnic vein thrombosis: clinical presentation, risk factors and treatment.

    abstract::The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (BCS), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis; the simultaneous involvement of additional regions is frequent, and clinical presentations and risk factors may be shared. The annual incidence of BCS and isolated m...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-010-0413-6

    authors: De Stefano V,Martinelli I

    更新日期:2010-12-01 00:00:00

  • The management of patients with venous thromboembolism in Italy: insights from the PREFER in VTE registry.

    abstract::Venous thromboembolism (VTE) is the third most common cardiovascular disease. Real-life data on the clinical presentation, risk factors, diagnosis, and treatment of VTE in Italy and Europe are required to optimize the management of this disease. The PREFER in VTE registry, a prospective non-interventional real-life st...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1507-6

    authors: Guercini F,Mommi V,Camporese G,Tonello C,Imberti D,Benedetti R,De Bartolomeo G,Di Lecce L,Romeo F,Agnelli G

    更新日期:2016-12-01 00:00:00

  • Management of idiopathic recurrent pericarditis in adults and in children: a role for IL-1 receptor antagonism.

    abstract::Recurrent pericarditis is one of the most frequent pericardial diseases, affecting up to 30% of the patients who have experienced acute pericarditis. While the diagnosis of acute pericarditis is sometime straight forward, its etiology and therapeutic management are still a challenge for physicians. In developed countr...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-018-1842-x

    authors: Brucato A,Emmi G,Cantarini L,Di Lenarda A,Gattorno M,Lopalco G,Marcolongo R,Imazio M,Martini A,Prisco D

    更新日期:2018-06-01 00:00:00

  • A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations.

    abstract::Coronavirus disease 2019 (COVID-19) is an emerging infectious disease which has had a rapid surge in cases and deaths since it is first documented in Wuhan, China, in December 2019. COVID-19 is caused by the Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses angiotensin-conve...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-020-02616-5

    authors: Krishnan A,Hamilton JP,Alqahtani SA,A Woreta T

    更新日期:2021-01-16 00:00:00

  • Hospital length-of-stay and costs among pulmonary embolism patients treated with rivaroxaban versus parenteral bridging to warfarin.

    abstract::We sought to compare length-of-stay (LOS), total hospital costs, and readmissions among pulmonary embolism (PE) patients treated with rivaroxaban versus parenterally bridged warfarin. We identified adult PE (primary diagnostic code = 415.1x) patients in the Premier Database (11/2012-9/2015), and included those with ≥1...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1552-1

    authors: Weeda ER,Wells PS,Peacock WF,Fermann GJ,Baugh CW,Ashton V,Crivera C,Wildgoose P,Schein JR,Coleman CI

    更新日期:2017-04-01 00:00:00