Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding.

Abstract:

:Hypertension and diabetes are known risk factors for obesity-related thrombosis, but several studies have shown that obesity is characterised by a potentially prothrombotic inflammatory state because of activated coagulation and impaired fibrinolysis. In order to verify if obese patients-unaffected by hypertension, diabetes, dyslipidemia, cigarette smoking or inflammatory diseases-show increased prothrombotic markers and whether the weight loss induced by gastric banding normalises such parameters. Plasma levels of C reactive protein (CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (VWF) and factor VII (FVII) were measured in 25 women with isolated obesity prior to, as well as 3, 6 and 12 months subsequent to gastric banding. Twenty-five healthy women served as a baseline control group. The obese women had higher CRP (p = 0.0001), fibrinogen (p = 0.014), PAI-1 (p = 0.003), VWF (p = 0.004) and FVII levels (p = 0.0001) than the normal controls, and their body mass index (BMI) positively correlated with CRP (r = 0.462, p = 0.02), fibrinogen (r = 0.426, p = 0.04) and PAI-1 (r = 0.468, p = 0.02). Twelve months after gastric banding, the median BMI had decreased from 40.0 to 34.9 (p = 0.0001); CRP from 4.18 to 1.69 μg/ml (p = 0.01); fibrinogen from 389 to 318 mg/dl (p = 0.0001); PAI-1 from 32.1 to 12.0 UI/ml (p = 0.003); VWF from 144 to 120% (p = 0.0001); and FVII from 134 to 112% (p = 0.002). Even in the absence of major cardiovascular risk factors, obese patients are characterised by a prothrombotic state. The weight loss induced by gastric banding decreases the parameters of inflammation, coagulation and impaired fibrinolysis, thus potentially reducing the thrombotic risk.

journal_name

Intern Emerg Med

authors

Cugno M,Castelli R,Mari D,Mozzi E,Zappa MA,Boscolo-Anzoletti M,Roviaro G,Mannucci PM

doi

10.1007/s11739-011-0522-x

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

237-42

issue

3

eissn

1828-0447

issn

1970-9366

journal_volume

7

pub_type

杂志文章
  • Endometriosis, need for a multidisciplinary clinical setting: the internist's point of view.

    abstract::Endometriosis is a common condition characterized by proliferation of endometrial tissue outside the uterus, both in the pelvis and in other extra-pelvic sites. The clinical picture of endometriosis is widely heterogeneous. A correct diagnostic work-up of these patients can sometimes be very difficult, since there are...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-010-0404-7

    authors: Montalto M,Santoro L,D'Onofrio F,Gallo A,Campo S,Campo V,Gasbarrini A,Gasbarrini G

    更新日期:2010-12-01 00:00:00

  • Chronic kidney disease and kidney health care status: the healthy life in Suriname (HeliSur) study.

    abstract::The high cardiovascular risk burden in low- and middle-income countries is expected to lead to an explosive increase in chronic kidney disease (CKD). However, population data on CKD from these countries are scarce. Therefore, we assessed kidney health in Suriname. In the Healthy Life in Suriname (HeliSur) study, a ran...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1962-3

    authors: Nannan Panday R,Haan Y,Diemer F,Punwasi A,Rommy C,Heerenveen I,van Montfrans GA,Brewster LM

    更新日期:2019-03-01 00:00:00

  • The effect of management models on thromboembolic and bleeding rates in anticoagulated patients: an ecological study.

    abstract::The primary study objective is to compare the outcomes of patients taking oral anticoagulant medications in two distinct populations treated according to different management models (comprehensive vs. usual care). (Design: regional prospective cohort study; setting: hospital admission data from two regions). Eligible ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-019-02148-7

    authors: Tosetto A,Testa S,Palareti G,Paoletti O,Nichele I,Catalano F,Morandini R,Di Paolo M,Tala M,Esteban P,Cora' F,Mannino S,Maroni A,Sessa M,Castaman G

    更新日期:2019-11-01 00:00:00

  • Screening of new bioactive metabolites for diabetes therapy.

    abstract::Microorganisms and plants produce bioactive metabolites that are potentially useful in the treatment of disease. We have designed and synthesized DHMEQ as a specific inhibitor of NF-κB based on the structure of epoxyquinomicin. It directly binds to NF-κB components to inhibit DNA-binding and was shown to be endowed wi...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-013-0922-1

    authors: Sidthipong K,Todo S,Takei I,Kojima I,Umezawa K

    更新日期:2013-04-01 00:00:00

  • Point-of-care ultrasound modalities in terms of diagnosing acute decompensated heart failure in emergency department; a diagnostic accuracy study.

    abstract::This study aimed to compare the diagnostic accuracy of heart, lung and inferior vena cava (IVC) ultrasonography modalities, alone and combined, for possible added accuracy in diagnosing acute decompensated heart failure (ADHF), in a group of patients with the final diagnosis of ADHF based on plasma level of B-type nat...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-019-02233-x

    authors: Farahmand S,Abdolhoseini A,Aliniagerdroudbari E,Babaniamansour S,Baratloo A,Bagheri-Hariri S

    更新日期:2020-04-01 00:00:00

  • Author Correction: Toxic alcohol diagnosis and management: an emergency medicine review.

    abstract::Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. Th...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11739-018-1833-y

    authors: Ng PC,Long BJ,Davis WT,Sessions DJ,Koyfman A

    更新日期:2018-08-01 00:00:00

  • Association between in-hospital acute hypertensive episodes and outcomes in older trauma patients.

    abstract::Although chronic hypertension is associated with long-term complications, few studies directly examine the effects of in-hospital acute hypertensive episodes in trauma patients. The aim was to determine whether there is an association between in-hospital acute hypertension and morbidity. We included trauma patients be...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-013-0984-0

    authors: Saliba L,Stawicki SP,Thongrong C,Bergese SD,Papadimos TJ,Gerlach AT

    更新日期:2014-08-01 00:00:00

  • The utility of head computed tomography in the emergency department evaluation of syncope.

    abstract:OBJECTIVE:Current guidelines for evaluation of syncope recommend that in the absence of objective focal neurologic findings, head computed tomography (HCT) may not be necessary. Compliance with this recommendation is highly variable, which may be due in part to the lack of currently available evidence. We undertook the...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/BF02936543

    authors: Goyal N,Donnino MW,Vachhani R,Bajwa R,Ahmad T,Otero R

    更新日期:2006-01-01 00:00:00

  • Association between hemoglobin levels and clinical outcomes in adult patients after in-hospital cardiac arrest: a retrospective cohort study.

    abstract::In addition to cardiac output, oxygen delivery is determined by the amount of oxygen carried by hemoglobin, which is estimated by the product of hemoglobin level and peripheral hemoglobin oxygen saturation (SpO2). Optimal hemoglobin concentration for post-cardiac arrest syndrome (PCAS) has not yet been investigated th...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-015-1386-2

    authors: Wang CH,Huang CH,Chang WT,Tsai MS,Yu PH,Wang AY,Chen NC,Chen WJ

    更新日期:2016-08-01 00:00:00

  • Is there a link between venous and arterial thrombosis? A reappraisal.

    abstract::Whether there is a link between venous and arterial thrombotic disorders is still a matter of debate. They share common risk factors, such as old age, male sex and obesity. Endothelial dysfunction and inflammation are likely to play a role in determining the simultaneous involvement of the two vascular compartments. U...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-019-02238-6

    authors: Prandoni P

    更新日期:2020-01-01 00:00:00

  • Predictors of the early outcome in elderly patients with ST elevation myocardial infarction treated with primary angioplasty: a single center experience.

    abstract::Elderly patients are under-represented in trials assessing strategies of early coronary revascularization in acute myocardial infarction, though they are the fastest growing segment of our population. The aims of the present investigation, performed in 357 elderly (≥75 years) patients with ST elevation myocardial infa...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-010-0459-5

    authors: Lazzeri C,Valente S,Chiostri M,Picariello C,Gensini GF

    更新日期:2011-02-01 00:00:00

  • Infectious complications in neutropenic cancer patients.

    abstract::Cancer patients are at risk of infectious complications due to neutropenia following chemotherapy or early post-HSCT (Hemato Stem Cell Transplantation). The first episode of fever during recent onset neutropenia is caused mostly by bacteria, while subsequent episodes are mainly fungal in nature. Proper management of i...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-010-0456-8

    authors: Menichetti F

    更新日期:2010-10-01 00:00:00

  • Genetic and nutritional factors determining circulating levels of lipoprotein(a): results of the "Montignoso Study".

    abstract::Increasing evidence shows an association between high lipoprotein(a) [Lp(a)] levels and atherothrombotic diseases. Lp(a) trait is largely controlled by kringle-IV type 2 (KIV-2) size polymorphism in LPA gene, encoding for apo(a). Environmental factors are considered to determinate minor phenotypic variability in Lp(a)...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02276-5

    authors: Sereni A,Sticchi E,Gori AM,Magi A,Della Latta D,Volta A,Murri A,Jamagidze G,Chiappino D,Abbate R,Gensini GF,Marcucci R,Sofi F,Giusti B

    更新日期:2020-10-01 00:00:00

  • Relation between admission serum potassium levels and long-term mortality in acute coronary syndrome.

    abstract::Serum potassium homeostasis play an important role in myocardial function, but the impact of serum potassium levels on long-term mortality has not been well evaluated. In the current study, we investigated patients with acute coronary syndrome (ACS) and analyzed the relationship between admission serum potassium level...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-015-1253-1

    authors: Peng Y,Huang FY,Liu W,Zhang C,Zhao ZG,Huang BT,Liao YB,Li Q,Chai H,Luo XL,Ren X,Chen C,Meng QT,Huang DJ,Wang H,Chen M

    更新日期:2015-12-01 00:00:00

  • The prognostic role of gamma-glutamyltransferase activity in non-diabetic ST-elevation myocardial infarction.

    abstract::In patients with acute coronary syndrome, gamma-glutamyltransferase activity (GGT) proved to be an independent predictor of the development of major adverse cardiac events at early and long terms. No data are available on GGT in ST-elevation myocardial infarction (STEMI). We assessed, in 337 consecutive STEMI patients...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-010-0464-8

    authors: Lazzeri C,Valente S,Tarquini R,Chiostri M,Picariello C,Gensini GF

    更新日期:2011-06-01 00:00:00

  • Non-alcoholic fatty liver disease and cardiovascular disease: epidemiological, clinical and pathophysiological evidences.

    abstract::Non-alcoholic fatty liver disease is recognized as the most common and emerging chronic liver disease in western countries. The disease has been traditionally interpreted as a possibly progressing condition to liver fibrosis and cirrhosis. However, recently, a large number of publications have demonstrated that people...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-012-0819-4

    authors: Del Ben M,Baratta F,Polimeni L,Angelico F

    更新日期:2012-10-01 00:00:00

  • Cardiovascular oncology: a new discipline inside internal medicine?

    abstract::Cardiovascular disease and cancer incidence and prevalence have risen over the past few decades to become the leading causes of death. On the one hand, cancer patients will be treated with cardiotoxic chemotherapies; on the other, cardiovascular patients will receive a new diagnosis of cancer and will have to face tre...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-014-1064-9

    authors: Prisco D,D'Elios MM,Cenci C,Ciucciarelli L,Tamburini C

    更新日期:2014-06-01 00:00:00

  • The difficulties of polytherapy: examples from antimicrobial chemotherapy.

    abstract::Medical therapy in patients with more than one pathology means using more pharmaceuticals, which results in a higher risk of drug interactions which are modifications in the action of one drug when it is administered in the presence of another. The consequences can be diminished therapeutic effect or increased adverse...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0680-x

    authors: Mazzei T

    更新日期:2011-10-01 00:00:00

  • Treatment outcome in a cohort of young patients with polycythemia vera.

    abstract::The treatment of polycythemia vera in young adults is challenging, requiring one to run a balance between the increased risk of vascular complications, if left untreated, versus the potential of promoting secondary leukemia/myelodysplasia or cancer, if actively managed with chemotherapy. We report the results of a 20-...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-010-0429-y

    authors: Ruggeri M,Finotto S,Fortuna S,Rodeghiero F

    更新日期:2010-10-01 00:00:00

  • Direct oral anticoagulants in atrial fibrillation: can data from randomized clinical trials be safely transferred to the general population? Yes.

    abstract::Atrial fibrillation is the most common arrhythmia and is associated with significant morbidity and mortality. The current therapeutic options for patients at high thromboembolic risk include the vitamin K antagonists and the direct oral anticoagulants. These novel agents have been evaluated in more than 40,000 patient...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-015-1277-6

    authors: Riva N,Ageno W

    更新日期:2015-09-01 00:00:00

  • Correlation between religion and hypertension.

    abstract::The objectives of the study were to investigate the relationship between religion and hypertension, as well as the theoretical mechanism through which religion exerts effect on hypertension. A MEDLINE literature search was performed on articles describing religion and hypertension (N = 543) excluding unqualified ones ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1791-4

    authors: Meng Q,Zhang X,Shi R,Liao H,Chen X

    更新日期:2019-03-01 00:00:00

  • Cognitive impairment in patients hospitalized for congestive heart failure: data from the RICA Registry.

    abstract::The objective of this study is to determine the prevalence of cognitive impairment (CogI) in patients hospitalized for congestive heart failure, and the influence of CogI on mortality and hospital readmission. This is a multicenter cohort study of patients hospitalized for congestive heart failure enrolled in the RICA...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02400-5

    authors: García Bruñén JM,Povar Echeverria M,Díez-Manglano J,Manzano L,Trullàs JC,Romero Requena JM,Salamanca Bautista MP,González Franco Á,Cepeda Rodrigo JM,Montero-Pérez-Barquero M,RICA Investigators Group.

    更新日期:2021-01-01 00:00:00

  • The efficacy and safety of high-dose statins in acute phase of ischemic stroke and transient ischemic attack: a systematic review.

    abstract::Inconsistent findings in the studies have been observed concerning the higher dose of statins use in the acute phase of ischemic stroke and transient ischemic attack (TIA). Therefore, we performed a systematic review to assess this issue. A computerized literature search in PubMed, Cochrane Library databases, and EMBA...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-017-1650-8

    authors: Fang JX,Wang EQ,Wang W,Liu Y,Cheng G

    更新日期:2017-08-01 00:00:00

  • New direct thrombin inhibitors.

    abstract::Direct thrombin inhibitors (DTIs) are a class of anticoagulants that bind selectively to thrombin and block its interaction with its substrates. Dabigatran etexilate and AZD0837, the new generation of DTIs, are now under intense development, and are potentially of great interest for internists. Dabigatran etexilate is...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-009-0314-8

    authors: Squizzato A,Dentali F,Steidl L,Ageno W

    更新日期:2009-12-01 00:00:00

  • Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience.

    abstract::The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0619-2

    authors: Valente S,Lazzeri C,Chiostri M,Alterini B,Ognibene A,Giglioli C,Pigozzi C,Gensini GF

    更新日期:2013-06-01 00:00:00

  • Correction to: Prognostic influence of prior chronic obstructive pulmonary disease in patients admitted for their first episode of acute heart failure.

    abstract::In the original publication, the given name and family name of the fifth author Dr Margherita Migone De Amicis were incorrectly published. The correct given name and family name should read as 'Margherita' and 'Migone De Amicis', respectively. ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11739-018-1921-z

    authors: Londoño KL,Formiga F,Chivite D,Moreno-Gonzalez R,Migone De Amicis M,Corbella X

    更新日期:2018-09-01 00:00:00

  • Pneumonia in frail older patients: an up to date.

    abstract::Despite advances in diagnosis, antimicrobial therapy and supportive care modalities, community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality, especially in patients who require hospitalization. Elderly patients with poor functional status are characterized by a higher risk of developin...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-012-0796-7

    authors: Falcone M,Blasi F,Menichetti F,Pea F,Violi F

    更新日期:2012-10-01 00:00:00

  • Validation of the Italian version of a new coma scale: the FOUR score.

    abstract::The Glasgow Coma Scale (GCS) is the most widely accepted tool for the evaluation of consciousness, despite several reported shortcomings. A new coma scale, named Full Outline of UnResponsiveness (FOUR) score, is now available. The aim of the present study is to provide and validate the Italian version of the FOUR scor...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0583-x

    authors: Marcati E,Ricci S,Casalena A,Toni D,Carolei A,Sacco S

    更新日期:2012-04-01 00:00:00

  • Impact of gender on short-term and long-term all-cause mortality in patients with non-ST-segment elevation acute coronary syndromes: a meta-analysis.

    abstract::A meta-analysis to determine the impact of gender on mortality in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS): PubMed, EMBASE, and Cochrane Library, was systematically searched. Two investigators independently reviewed retrieved articles and assessed eligibility. Unadjusted mortality rat...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11739-017-1684-y

    authors: Wang Y,Zhu S,Du R,Zhou J,Chen Y,Zhang Q

    更新日期:2018-03-01 00:00:00

  • A simple lung ultrasound protocol for the screening of COVID-19 pneumonia in the emergency department.

    abstract::The most relevant manifestation of coronavirus disease 2019 (COVID-19) is interstitial pneumonia. Several lung ultrasound (US) protocols for pneumonia diagnosis are used in clinical practice, but none has been proposed for COVID-19 patients' screening in the emergency department. We adopted a simplified 6-scan lung US...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02596-6

    authors: Dacrema A,Silva M,Rovero L,Vertemati V,Losi G,Piepoli MF,Sacchi R,Mangiacotti M,Nazerian P,Pagani L,Tinelli V,Poggiali E,Bastoni D,Vercelli A,Magnacavallo A

    更新日期:2021-01-11 00:00:00