Pneumonia in frail older patients: an up to date.

Abstract:

:Despite advances in diagnosis, antimicrobial therapy and supportive care modalities, community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality, especially in patients who require hospitalization. Elderly patients with poor functional status are characterized by a higher risk of developing severe CAP, due to the frequent presence of underlying respiratory and cardiac diseases, alteration of mental status, and immunosuppression. In recent years, changes in the healthcare system have shifted a considerable part of older patient care from hospitals to the community, and the traditional distinction between community- and hospital-acquired infections has become less clear. Pneumonia occurring among outpatients in contact with the healthcare system has been termed healthcare-associated pneumonia. Older frail patients have a high frequency of aspiration pneumonia and pneumonia due to gram-negative bacilli and other multidrug resistant pathogens. The contemporary presence of renal impairment usually requires specific dose adjustment of antibiotic therapy, which may be toxic in this specific patient population. This review produces a summary of therapeutic recommendations on the basis of the most updated clinical and pharmacological data.

journal_name

Intern Emerg Med

authors

Falcone M,Blasi F,Menichetti F,Pea F,Violi F

doi

10.1007/s11739-012-0796-7

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

415-24

issue

5

eissn

1828-0447

issn

1970-9366

journal_volume

7

pub_type

杂志文章,评审
  • Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience.

    abstract::The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0619-2

    authors: Valente S,Lazzeri C,Chiostri M,Alterini B,Ognibene A,Giglioli C,Pigozzi C,Gensini GF

    更新日期:2013-06-01 00:00:00

  • Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding.

    abstract::Hypertension and diabetes are known risk factors for obesity-related thrombosis, but several studies have shown that obesity is characterised by a potentially prothrombotic inflammatory state because of activated coagulation and impaired fibrinolysis. In order to verify if obese patients-unaffected by hypertension, di...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0522-x

    authors: Cugno M,Castelli R,Mari D,Mozzi E,Zappa MA,Boscolo-Anzoletti M,Roviaro G,Mannucci PM

    更新日期:2012-06-01 00:00:00

  • The effect of management models on thromboembolic and bleeding rates in anticoagulated patients: an ecological study.

    abstract::The primary study objective is to compare the outcomes of patients taking oral anticoagulant medications in two distinct populations treated according to different management models (comprehensive vs. usual care). (Design: regional prospective cohort study; setting: hospital admission data from two regions). Eligible ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-019-02148-7

    authors: Tosetto A,Testa S,Palareti G,Paoletti O,Nichele I,Catalano F,Morandini R,Di Paolo M,Tala M,Esteban P,Cora' F,Mannino S,Maroni A,Sessa M,Castaman G

    更新日期:2019-11-01 00:00:00

  • Association between hemoglobin levels and clinical outcomes in adult patients after in-hospital cardiac arrest: a retrospective cohort study.

    abstract::In addition to cardiac output, oxygen delivery is determined by the amount of oxygen carried by hemoglobin, which is estimated by the product of hemoglobin level and peripheral hemoglobin oxygen saturation (SpO2). Optimal hemoglobin concentration for post-cardiac arrest syndrome (PCAS) has not yet been investigated th...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-015-1386-2

    authors: Wang CH,Huang CH,Chang WT,Tsai MS,Yu PH,Wang AY,Chen NC,Chen WJ

    更新日期:2016-08-01 00:00:00

  • Screening of new bioactive metabolites for diabetes therapy.

    abstract::Microorganisms and plants produce bioactive metabolites that are potentially useful in the treatment of disease. We have designed and synthesized DHMEQ as a specific inhibitor of NF-κB based on the structure of epoxyquinomicin. It directly binds to NF-κB components to inhibit DNA-binding and was shown to be endowed wi...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-013-0922-1

    authors: Sidthipong K,Todo S,Takei I,Kojima I,Umezawa K

    更新日期:2013-04-01 00:00:00

  • E-cigarette use is strongly associated with recent smoking cessation: an analysis of a representative population sample in Greece.

    abstract::The purpose was to examine the association between e-cigarette use and smoking cessation according to quit duration in Greece in 2017. A cross-sectional survey of a representative sample of adults living in Attica prefecture was performed in May 2017 through telephone interviews. The present analysis was confined to c...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-02023-x

    authors: Farsalinos K,Siakas G,Poulas K,Voudris V,Merakou K,Barbouni A

    更新日期:2019-09-01 00:00:00

  • Chronic kidney disease and kidney health care status: the healthy life in Suriname (HeliSur) study.

    abstract::The high cardiovascular risk burden in low- and middle-income countries is expected to lead to an explosive increase in chronic kidney disease (CKD). However, population data on CKD from these countries are scarce. Therefore, we assessed kidney health in Suriname. In the Healthy Life in Suriname (HeliSur) study, a ran...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1962-3

    authors: Nannan Panday R,Haan Y,Diemer F,Punwasi A,Rommy C,Heerenveen I,van Montfrans GA,Brewster LM

    更新日期:2019-03-01 00:00:00

  • Bedside ultrasonography (US), Echoscopy and US point of care as a new kind of stethoscope for Internal Medicine Departments: the training program of the Italian Internal Medicine Society (SIMI).

    abstract::In recent years, thanks to the development of miniaturized ultrasound devices, comparable to personal computers, tablets and even to smart phones, we have seen an increasing use of bedside ultrasound in internal medicine departments as a novel kind of ultrasound stethoscope. The clinical ultrasound-assisted approach h...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-014-1113-4

    authors: Arienti V,Di Giulio R,Cogliati C,Accogli E,Aluigi L,Corazza GR,Ultrasound SIMI Study Group.

    更新日期:2014-10-01 00:00:00

  • Correction to: Reversal agents for oral anticoagulant-associated major or life-threatening bleeding.

    abstract::The article Reversal agents for oral anticoagulant-associated major or life-threatening bleeding, written by Marco Moia, Alessandro Squizzato was originally published electronically on the publisher's internet portal (currently SpringerLink) on 24 August 2019 without open access. ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11739-019-02232-y

    authors: Moia M,Squizzato A

    更新日期:2020-06-01 00:00:00

  • Etomidate use in severe sepsis and septic shock patients does not contribute to mortality.

    abstract::Use of etomidate in severe sepsis and septic shock has been challenged in recent literature due to its link to adrenal insufficiency and suspected increased mortality. We hypothesized that etomidate does not contribute to mortality in this patient population. A retrospective chart review of 230 intubated, severe sepsi...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0553-3

    authors: Ehrman R,Wira C,Lomax A,Hayward A,Marcelin J,Ellis T,Przyklenk K,Volturo G,Mullen M

    更新日期:2011-06-01 00:00:00

  • Usefulness of procalcitonin level as an outcome predictor of adult bacterial meningitis.

    abstract::Acute bacterial meningitis is rare, but can be fulminant unless rapidly evaluated and treated. The aim of this study was to evaluate whether serum procalcitonin (PCT) levels could predict unfavorable outcomes of bacterial meningitis. We retrospectively reviewed the medical records of 604 meningitis patients from the e...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1509-4

    authors: Ko BS,Ryoo SM,Ahn S,Sohn CH,Seo DW,Kim WY

    更新日期:2017-10-01 00:00:00

  • Cardiovascular oncology: a new discipline inside internal medicine?

    abstract::Cardiovascular disease and cancer incidence and prevalence have risen over the past few decades to become the leading causes of death. On the one hand, cancer patients will be treated with cardiotoxic chemotherapies; on the other, cardiovascular patients will receive a new diagnosis of cancer and will have to face tre...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-014-1064-9

    authors: Prisco D,D'Elios MM,Cenci C,Ciucciarelli L,Tamburini C

    更新日期:2014-06-01 00:00:00

  • Cognitive impairment in patients hospitalized for congestive heart failure: data from the RICA Registry.

    abstract::The objective of this study is to determine the prevalence of cognitive impairment (CogI) in patients hospitalized for congestive heart failure, and the influence of CogI on mortality and hospital readmission. This is a multicenter cohort study of patients hospitalized for congestive heart failure enrolled in the RICA...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02400-5

    authors: García Bruñén JM,Povar Echeverria M,Díez-Manglano J,Manzano L,Trullàs JC,Romero Requena JM,Salamanca Bautista MP,González Franco Á,Cepeda Rodrigo JM,Montero-Pérez-Barquero M,RICA Investigators Group.

    更新日期:2021-01-01 00:00:00

  • Colchicine is safe and effective for secondary prevention of recurrent pericarditis.

    abstract::The CORP (COlchicine for Recurrent Pericarditis) trial [7]is a prospective, randomized, double-blind, placebo controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in association with conventional ant...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s11739-012-0775-z

    authors: Gianni F,Solbiati M,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2012-04-01 00:00:00

  • Supraglottic jet oxygenation and ventilation-assisted fibre-optic bronchoscope intubation in patients with difficult airways.

    abstract::A difficult airway may lead to hypoxia and brain damage. The WEI Nasal Jet Tube (WNJ) is a new nasal pharyngeal tube that applies supraglottic jet oxygenation and ventilation (SJOV) for patients during tracheal intubation without the need for mask ventilation. We evaluated the effectiveness and safety of SJOV-assisted...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1531-6

    authors: Wu C,Wei J,Cen Q,Sha X,Cai Q,Ma W,Cao Y

    更新日期:2017-08-01 00:00:00

  • The utility of head computed tomography in the emergency department evaluation of syncope.

    abstract:OBJECTIVE:Current guidelines for evaluation of syncope recommend that in the absence of objective focal neurologic findings, head computed tomography (HCT) may not be necessary. Compliance with this recommendation is highly variable, which may be due in part to the lack of currently available evidence. We undertook the...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/BF02936543

    authors: Goyal N,Donnino MW,Vachhani R,Bajwa R,Ahmad T,Otero R

    更新日期:2006-01-01 00:00:00

  • Six minute walk test: a simple and useful test to evaluate functional capacity in patients with heart failure.

    abstract::In heart failure survival is closely related to functional capacity. Peak O2 consumption at cardiopulmonary exercise test (CPET) is considered the gold standard for the evaluation of exercise tolerance. Since >70% of patients with heart failure, usually elderly or with significant comorbidities, are referred to Depart...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-008-0130-6

    authors: Rostagno C,Gensini GF

    更新日期:2008-09-01 00:00:00

  • The effect of body mass index on intubation success rates and complications during emergency airway management.

    abstract::We evaluated the effect of body mass index (BMI) on intubation success rates and complications during emergency airway management. We retrospectively analyzed an airway registry at an academic medical center. The primary outcomes were the incidence of difficult intubation and complication rates, stratified by BMI. We ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-012-0874-x

    authors: Dargin JM,Emlet LL,Guyette FX

    更新日期:2013-02-01 00:00:00

  • Safety and efficacy of sucrosomial iron in inflammatory bowel disease patients with iron deficiency anemia.

    abstract::Iron deficiency anemia (IDA) is one of the most common complications of inflammatory bowel disease (IBD). We planned a prospective study to address tolerability and efficacy of sucrosomial iron, a new oral formulation of ferric pyrophosphate, in IBD patients. Thirty patients with a confirmed diagnosis of Crohn's Disea...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1993-9

    authors: Abbati G,Incerti F,Boarini C,Pileri F,Bocchi D,Ventura P,Buzzetti E,Pietrangelo A

    更新日期:2019-04-01 00:00:00

  • Quality of life impairment in Behçet's disease and relationship with disease activity: a prospective study.

    abstract::Our aim was to prospectively investigate the impact of Behçet's disease (BD), disease activity, and clinical and demographic characteristics on different aspects of quality of life (QoL) measured by the short-form (SF)-36 QoL scale. We administered the SF-36 to 37 consecutive BD patients in different moments of diseas...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-017-1691-z

    authors: Fabiani C,Vitale A,Orlando I,Sota J,Capozzoli M,Franceschini R,Galeazzi M,Tosi GM,Frediani B,Cantarini L

    更新日期:2017-10-01 00:00:00

  • Prevention of anthracycline-induced cardiotoxicity: a systematic review and meta-analysis.

    abstract::Anthracyclines are extensively used in oncologic patients, in particular for breast cancer and hematological malignancies. Cardiac injury is a potentially dangerous side effect of these drugs. In this systematic review, we analyzed published randomized controlled trials (RCTs) to assess if potential cardioprotective d...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-020-02508-8

    authors: Caspani F,Tralongo AC,Campiotti L,Asteggiano R,Guasti L,Squizzato A

    更新日期:2020-10-03 00:00:00

  • Predictors of the early outcome in elderly patients with ST elevation myocardial infarction treated with primary angioplasty: a single center experience.

    abstract::Elderly patients are under-represented in trials assessing strategies of early coronary revascularization in acute myocardial infarction, though they are the fastest growing segment of our population. The aims of the present investigation, performed in 357 elderly (≥75 years) patients with ST elevation myocardial infa...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-010-0459-5

    authors: Lazzeri C,Valente S,Chiostri M,Picariello C,Gensini GF

    更新日期:2011-02-01 00:00:00

  • The incidence and significance of acute kidney injury following emergent contrast administration in patients with STEMI and stroke.

    abstract::The authors have investigated the incidence of acute kidney injury (AKI) and short-term mortality following an activated STEMI and stroke alert at a tertiary referral and academic center. A single center, retrospective chart review of STEMI and stroke activation patients from January 2010 to March 2012. Data was colle...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1407-9

    authors: Marchick MR,Allen BR,Weeks EC,Shuster JJ,Elie MC

    更新日期:2016-09-01 00:00:00

  • A simple lung ultrasound protocol for the screening of COVID-19 pneumonia in the emergency department.

    abstract::The most relevant manifestation of coronavirus disease 2019 (COVID-19) is interstitial pneumonia. Several lung ultrasound (US) protocols for pneumonia diagnosis are used in clinical practice, but none has been proposed for COVID-19 patients' screening in the emergency department. We adopted a simplified 6-scan lung US...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02596-6

    authors: Dacrema A,Silva M,Rovero L,Vertemati V,Losi G,Piepoli MF,Sacchi R,Mangiacotti M,Nazerian P,Pagani L,Tinelli V,Poggiali E,Bastoni D,Vercelli A,Magnacavallo A

    更新日期:2021-01-11 00:00:00

  • The difficulties of polytherapy: examples from antimicrobial chemotherapy.

    abstract::Medical therapy in patients with more than one pathology means using more pharmaceuticals, which results in a higher risk of drug interactions which are modifications in the action of one drug when it is administered in the presence of another. The consequences can be diminished therapeutic effect or increased adverse...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0680-x

    authors: Mazzei T

    更新日期:2011-10-01 00:00:00

  • Underuse of oral anticoagulants in patients with nonvalvular atrial fibrillation in Italy.

    abstract:INTRODUCTION:Oral anticoagulants (OAs) are significantly more effective than Aspirin in the prevention of cerebrovascular accidents among patients with atrial fibrillation (AF). Several studies, however, showed OAs to be widely underused in these patients. OBJECTIVE:To assess the appropriateness of antithrombotic ther...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-007-0005-2

    authors: Ferro D,Loffredo L,Polimeni L,Violi F

    更新日期:2007-03-01 00:00:00

  • Diagnosis and management of acute aortic syndromes in the emergency department.

    abstract::Acute aortic syndromes (AASs) are deadly cardiovascular emergencies involving the thoracic aorta. AASs are relatively rare conditions, have unspecific signs and symptoms (including truncal pain, syncope, neurologic deficit and limb ischemia) and require contrast-enhanced tomography angiography (CTA) of the chest and a...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-020-02354-8

    authors: Morello F,Santoro M,Fargion AT,Grifoni S,Nazerian P

    更新日期:2021-01-01 00:00:00

  • Emergencies in motoneuron disease.

    abstract::Genetic and acquired motor-neuron-disorders (MNDs) may undergo acute deterioration resulting in various emergency situations. This literature review aims at summarising and discussing current knowledge about emergencies in MNDs. Emergencies that have been reported in MND patients include: respiratory, bulbar, cardiac,...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-017-1644-6

    authors: Finsterer J,Stöllberger C

    更新日期:2017-08-01 00:00:00

  • Infliximab-related hepatitis: discussion of a case and review of the literature.

    abstract::Despite its rarity, infliximab-related hepatitis constitutes a cutting edge and challenging problem. In December 2004, a drug warning was issued by the Food and Drug Administration to alert healthcare professionals to the risk of hepatotoxicity in course of infliximab therapy. Subsequently, several reports of probable...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-009-0342-4

    authors: Mancini S,Amorotti E,Vecchio S,Ponz de Leon M,Roncucci L

    更新日期:2010-06-01 00:00:00

  • Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh-frozen plasma.

    abstract::Cirrhosis is characterized by a complex coagulation defect leading to the prolongation of the prothrombin and activated partial thromboplastin times (PT and APTT). Arbitrary PT cut-off values are still used as a yardstick to guide treatment with fresh-frozen plasma (FFP) or other pro-coagulant agents in patients under...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0528-4

    authors: Tripodi A,Chantarangkul V,Primignani M,Clerici M,Dell'era A,Aghemo A,Mannucci PM

    更新日期:2012-04-01 00:00:00