Abstract:
:The aim of this systematic review was to assess AKI (acute kidney injury) in adult patients, treated with vancomycin (V) + piperacillin/tazobactam (PT) compared to V monotherapy. Studies were found in Pubmed, Web of Science and Scopus databases. Articles not in English, pediatric studies and case reports were excluded. A study is eligible for inclusion if the adjusted Odds ratio (aOR) for AKI in V + PT compared to V monotherapy groups, could be extracted or determined from available data. Six retrospective cohort studies were eligible for inclusion criteria and so they were included in the analysis. All studies separately showed a significant higher risk of developing AKI (OR > 1, p < 0.05) in V + PT group compared to V monotherapy group. Considering the methodological difference of included studies, a random effect model was preferred. The model showed a pooled significant higher risk of developing AKI [OR 2.77 (95% CI 1.94, 3.96), p < 0.0001] in V + PT group compared to V group. Association of V and PT appears to be associated with a greater risk of AKI compared to V in monotherapy. These results may serve as the impetus for further evaluation into true mechanisms behind this additive nephrotoxic effect and its potential implications on mortality.
journal_name
Intern Emerg Medjournal_title
Internal and emergency medicineauthors
Ciarambino T,Giannico OV,Campanile A,Tirelli P,Para O,Signoriello G,Giordano Mdoi
10.1007/s11739-020-02287-2subject
Has Abstractpub_date
2020-03-01 00:00:00pages
327-331issue
2eissn
1828-0447issn
1970-9366pii
10.1007/s11739-020-02287-2journal_volume
15pub_type
杂志文章abstract::Inconsistent findings in the studies have been observed concerning the higher dose of statins use in the acute phase of ischemic stroke and transient ischemic attack (TIA). Therefore, we performed a systematic review to assess this issue. A computerized literature search in PubMed, Cochrane Library databases, and EMBA...
journal_title:Internal and emergency medicine
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pub_type: 杂志文章,已发布勘误
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