Errors in medical literature: not a question of impact.


:The editorial and peer-review processes should guarantee readers as to the reliability of published data. The first step of these processes is to check for errors. The aim of our study was to look for the presence of objective errors in consecutive articles published on three of the most authoritative clinical journals. Two reviewers evaluated the presence of any error in 200 consecutive original articles containing at least two tables, allowing a reanalysis of the data, published between October 2010 and April 2011. Error was considered any action different from what was planned. Errors were listed as: methodological, numerical and slips. They were considered as severe if numbers in the abstract were completely different from numbers reported in the full text. Among the 125 articles included in the study, 102 (82 %, 95 % CI 74-88 %) contained some kind of error, even multiple. Nine articles (7 %, 95 % CI 3-13 %) contained one slip, 92 articles (74 %, 95 % CI 65-81 %) contained at least one numerical error, and 22 articles (18 %, 95 % CI 11-25 %) contained one methodological error. Five articles (4 %, 95 % CI 1-9 %) contained one serious error. None of the errors retrieved (0 %, 95 % CI 0-2 %) would have changed the results of the studies. Most of the articles published in the most important medical journals present mistakes. Our results could be a clue to editorial and peer review systems system weaknesses. A debate within the scientific medical community about these systems, and possible alternative adjustments are needed.


Intern Emerg Med


Costantino G,Casazza G,Cernuschi G,Solbiati M,Birocchi S,Ceriani E,Duca P,Montano N




Has Abstract


2013-03-01 00:00:00












  • Cardiovascular and metabolic risks associated with PCOS.

    abstract::Polycystic ovary syndrome, the most common endocrine disorder of reproductive age women, is often associated with insulin resistance and associated disorders. The frequency of type 2 diabetes, hyperlipidemia, cardiac risk markers, structural vascular disease, and clinical disease events are increased in this populatio...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Cobin RH

    更新日期:2013-04-01 00:00:00

  • Predictors of the early outcome in elderly patients with ST elevation myocardial infarction treated with primary angioplasty: a single center experience.

    abstract::Elderly patients are under-represented in trials assessing strategies of early coronary revascularization in acute myocardial infarction, though they are the fastest growing segment of our population. The aims of the present investigation, performed in 357 elderly (≥75 years) patients with ST elevation myocardial infa...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Lazzeri C,Valente S,Chiostri M,Picariello C,Gensini GF

    更新日期:2011-02-01 00:00:00

  • Correction to: Prognostic influence of prior chronic obstructive pulmonary disease in patients admitted for their first episode of acute heart failure.

    abstract::In the original publication, the given name and family name of the fifth author Dr Margherita Migone De Amicis were incorrectly published. The correct given name and family name should read as 'Margherita' and 'Migone De Amicis', respectively. ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,已发布勘误


    authors: Londoño KL,Formiga F,Chivite D,Moreno-Gonzalez R,Migone De Amicis M,Corbella X

    更新日期:2018-09-01 00:00:00

  • Can C-reactive protein and white blood cell count alone rule out an urgent condition in acute abdominal pain?

    abstract::Up to 10% of all patients at the Emergency Department present for acute abdominal pain. The C-reactive protein (CRP) and white blood cell (WBC) are routinely determined as part of the workup of patients with abdominal pain. Three large prospective cohort studies comprising a total of 2961 adult patients with acute abd...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Paolillo C,Spallino I,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2016-02-01 00:00:00

  • Etomidate use in severe sepsis and septic shock patients does not contribute to mortality.

    abstract::Use of etomidate in severe sepsis and septic shock has been challenged in recent literature due to its link to adrenal insufficiency and suspected increased mortality. We hypothesized that etomidate does not contribute to mortality in this patient population. A retrospective chart review of 230 intubated, severe sepsi...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Ehrman R,Wira C,Lomax A,Hayward A,Marcelin J,Ellis T,Przyklenk K,Volturo G,Mullen M

    更新日期:2011-06-01 00:00:00

  • Clinical features of 1487 COVID-19 patients with outpatient management in the Greater Paris: the COVID-call study.

    abstract::Clinical features of COVID-19 have been mostly described in hospitalized patients with and without ICU admission. Yet, up to 80% of patients are managed in an outpatient setting. This population is poorly documented. In France, health authorities recommend outpatient management of patients presenting mild-to-moderate ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Lapostolle F,Schneider E,Vianu I,Dollet G,Roche B,Berdah J,Michel J,Goix L,Chanzy E,Petrovic T,Adnet F

    更新日期:2020-08-01 00:00:00

  • Association between hemoglobin levels and clinical outcomes in adult patients after in-hospital cardiac arrest: a retrospective cohort study.

    abstract::In addition to cardiac output, oxygen delivery is determined by the amount of oxygen carried by hemoglobin, which is estimated by the product of hemoglobin level and peripheral hemoglobin oxygen saturation (SpO2). Optimal hemoglobin concentration for post-cardiac arrest syndrome (PCAS) has not yet been investigated th...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Wang CH,Huang CH,Chang WT,Tsai MS,Yu PH,Wang AY,Chen NC,Chen WJ

    更新日期:2016-08-01 00:00:00

  • Endometriosis, need for a multidisciplinary clinical setting: the internist's point of view.

    abstract::Endometriosis is a common condition characterized by proliferation of endometrial tissue outside the uterus, both in the pelvis and in other extra-pelvic sites. The clinical picture of endometriosis is widely heterogeneous. A correct diagnostic work-up of these patients can sometimes be very difficult, since there are...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Montalto M,Santoro L,D'Onofrio F,Gallo A,Campo S,Campo V,Gasbarrini A,Gasbarrini G

    更新日期:2010-12-01 00:00:00

  • Treatment outcome in a cohort of young patients with polycythemia vera.

    abstract::The treatment of polycythemia vera in young adults is challenging, requiring one to run a balance between the increased risk of vascular complications, if left untreated, versus the potential of promoting secondary leukemia/myelodysplasia or cancer, if actively managed with chemotherapy. We report the results of a 20-...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Ruggeri M,Finotto S,Fortuna S,Rodeghiero F

    更新日期:2010-10-01 00:00:00

  • Prevalence and prognostic impact of left ventricular non-compaction in patients with thalassemia.

    abstract::A high incidence of isolated left ventricular non-compaction (LVNC) has been reported in previous studies on smaller cohorts of patients with thalassemia by cardiac MRI but the clinical impact of the finding is unknown. This prospective cohort study evaluates the prevalence and clinical implication of the finding. Pro...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Bonamini R,Imazio M,Faletti R,Gatti M,Xhyheri B,Limone M,Longo F,Piga A

    更新日期:2019-11-01 00:00:00

  • Brain natriuretic peptide as a preclinical marker of chronic pulmonary hypertension in patients with pulmonary embolism.

    abstract::Chronic thromboembolic pulmonary hypertension (CTPH) is a potential complication of pulmonary embolism (PE). Only few studies have assessed the role of brain natriuretic peptide (BNP) in patients with chronic pulmonary hypertension, and there are no data on the potential utility of BNP as a preclinical biomarker of CT...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Dentali F,Donadini M,Gianni M,Bertolini A,Lonn E,Venco A,Cattozzo G,Ageno W

    更新日期:2009-04-01 00:00:00

  • New direct thrombin inhibitors.

    abstract::Direct thrombin inhibitors (DTIs) are a class of anticoagulants that bind selectively to thrombin and block its interaction with its substrates. Dabigatran etexilate and AZD0837, the new generation of DTIs, are now under intense development, and are potentially of great interest for internists. Dabigatran etexilate is...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Squizzato A,Dentali F,Steidl L,Ageno W

    更新日期:2009-12-01 00:00:00

  • Transjugular intrahepatic portosystemic shunt (TIPS): current indications and strategies to improve the outcomes.

    abstract::Transjugular intrahepatic portosystemic shunt (TIPS) represents a very effective treatment of complications of portal hypertension. Established indications to TIPS in cirrhotic patients include portal hypertensive bleeding and refractory ascites. Over the years additional indications have been proposed, such as the tr...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Vizzutti F,Schepis F,Arena U,Fanelli F,Gitto S,Aspite S,Turco L,Dragoni G,Laffi G,Marra F

    更新日期:2020-01-01 00:00:00

  • Usefulness of procalcitonin level as an outcome predictor of adult bacterial meningitis.

    abstract::Acute bacterial meningitis is rare, but can be fulminant unless rapidly evaluated and treated. The aim of this study was to evaluate whether serum procalcitonin (PCT) levels could predict unfavorable outcomes of bacterial meningitis. We retrospectively reviewed the medical records of 604 meningitis patients from the e...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Ko BS,Ryoo SM,Ahn S,Sohn CH,Seo DW,Kim WY

    更新日期:2017-10-01 00:00:00

  • Antimicrobial stewardship in an Internal Medicine ward: effects on antibiotic consumption and on the use of carbapenems.

    abstract::Assessing the effects of an antimicrobial stewardship program (ASP) implemented in a 78-bed Internal Medicine ward of an Italian mid-sized acute care hospital of 296 beds (26,820 bed days/year in 2015 and 26,653 in 2016). The ASP, implemented in May 2016, included: (a) formulation and dissemination of local guidelines...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Fortini A,Faraone A,Di Pietro M,Cappugi C,Magnante G,Boccadori C,Bartolini S,Rabatti L

    更新日期:2018-12-01 00:00:00

  • Is echocardiography mandatory for patients with chronic kidney disease?

    abstract::This study aims at evaluating the prevalence of left ventricular diastolic dysfunction in a group of 319 hypertensive patients with stage 3b-4-5 chronic kidney disease (according to Kidney Disease Improving Global Outcomes classification), compared with 216 patients with essential hypertension and normal renal functio...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Nardi E,Mulè G,Nardi C,Geraci G,Giammanco A,Bentivegna R,Averna M

    更新日期:2019-09-01 00:00:00

  • Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding.

    abstract::Hypertension and diabetes are known risk factors for obesity-related thrombosis, but several studies have shown that obesity is characterised by a potentially prothrombotic inflammatory state because of activated coagulation and impaired fibrinolysis. In order to verify if obese patients-unaffected by hypertension, di...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Cugno M,Castelli R,Mari D,Mozzi E,Zappa MA,Boscolo-Anzoletti M,Roviaro G,Mannucci PM

    更新日期:2012-06-01 00:00:00

  • Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease.

    abstract::The objective of this study is to determine the prevalence of respiratory syncytial virus (RSV) and other viral respiratory pathogens in emergency department (ED) patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). COPD patients presenting to the ED with <10 days of AECOPD symptoms wer...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Camargo CA Jr,Ginde AA,Clark S,Cartwright CP,Falsey AR,Niewoehner DE

    更新日期:2008-12-01 00:00:00

  • Amiodarone-related thyroid dysfunction.

    abstract::Nowadays, amiodarone is the most commonly used antidysrhythmic drug in clinical practice. It is highly effective in the management of recurrent ventricular dysrhythmias, paroxysmal supraventricular dysrhythmias, including atrial fibrillation and flutter, and in the maintenance of sinus rhythm after electrical cardiove...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Hudzik B,Zubelewicz-Szkodzinska B

    更新日期:2014-12-01 00:00:00

  • Colchicine is safe and effective for secondary prevention of recurrent pericarditis.

    abstract::The CORP (COlchicine for Recurrent Pericarditis) trial [7]is a prospective, randomized, double-blind, placebo controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in association with conventional ant...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gianni F,Solbiati M,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2012-04-01 00:00:00

  • Intracranial bruits in meningitis.

    abstract::Intracranial bruits (ICB) are faint, high-pitched, and mostly heard on the orbit in the systolic phase of the cardiovascular cycle. This report discusses a case of Listeria monocytogenes meningitis in a 17-month-old male patient in whom ICB were auscultated. ICB is thought to be caused by compression of blood vessels ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Sugiura K,Ihara T

    更新日期:2021-01-03 00:00:00

  • Subclinical liver fibrosis in patients with idiopathic pulmonary fibrosis.

    abstract::Data on the presence of subclinical fibrosis across multiple organs in patients with idiopathic lung fibrosis (IPF) are lacking. Our study aimed at investigating through hepatic transient elastography (HTE) the prevalence and clinical impact of subclinical liver fibrosis in a cohort of patients with IPF. Patients refe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Cocconcelli E,Tonelli R,Abbati G,Marchioni A,Castaniere I,Pelizzaro F,Russo FP,Vegetti A,Balestro E,Pietrangelo A,Richeldi L,Luppi F,Spagnolo P,Clini E,Cerri S

    更新日期:2020-05-25 00:00:00

  • Survival protection by bodyweight in isolated scleroderma-related pulmonary artery hypertension.

    abstract::In chronic heart failure (CHF) due to systemic cardiovascular disease, obese patients have better survival. Bodyweight versus survival was analyzed post hoc in subjects with limited scleroderma (SSc) and isolated pulmonary artery hypertension (PAH), i.e. with CHF due to pulmonary vascular disease. Rheumatologists refe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Marini C,Formichi B,Bauleo C,Michelassi C,Airò E,Rossi G,Giuntini C

    更新日期:2016-10-01 00:00:00

  • Author Correction: Toxic alcohol diagnosis and management: an emergency medicine review.

    abstract::Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. Th...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,已发布勘误


    authors: Ng PC,Long BJ,Davis WT,Sessions DJ,Koyfman A

    更新日期:2018-08-01 00:00:00

  • ESC position paper on cardiovascular toxicity of cancer treatments: challenges and expectations.

    abstract::The recent position paper of the European Society of Cardiology (ESC) on cardiovascular toxicity of cancer treatments has attracted considerable interest by healthcare professionals, since it is the first concrete help in the difficult task of monitoring and approaching cardiovascular side effects of anticancer treatm...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Raschi E,Diemberger I,Cosmi B,De Ponti F

    更新日期:2018-01-01 00:00:00

  • Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients.

    abstract::Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper endoscopy for dyspe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Dore MP,Marras G,Rocchi C,Soro S,Loria MF,Bassotti G,Graham DY,Malaty HM,Pes GM

    更新日期:2015-10-01 00:00:00

  • Clinical impact of application of risk assessment models (Padua Prediction Score and Improve Bleeding Score) on venous thromboembolism, major hemorrhage and health expenditure associated with pharmacologic VTE prophylaxis: a "real life" prospective and re

    abstract::International guidelines recommend the use of pharmacological prophylaxis in hospitalized medical patients at high risk of venous thromboembolism (VTE). The same international guidelines suggest the employment of standardized risk assessment models (RAMs) when evaluating the administration of pharmacological prophylax...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Depietri L,Marietta M,Scarlini S,Marcacci M,Corradini E,Pietrangelo A,Ventura P

    更新日期:2018-06-01 00:00:00

  • The prognostic role of gamma-glutamyltransferase activity in non-diabetic ST-elevation myocardial infarction.

    abstract::In patients with acute coronary syndrome, gamma-glutamyltransferase activity (GGT) proved to be an independent predictor of the development of major adverse cardiac events at early and long terms. No data are available on GGT in ST-elevation myocardial infarction (STEMI). We assessed, in 337 consecutive STEMI patients...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Lazzeri C,Valente S,Tarquini R,Chiostri M,Picariello C,Gensini GF

    更新日期:2011-06-01 00:00:00

  • Italian intersociety consensus on DOAC use in internal medicine.

    abstract::The direct oral anticoagulants (DOACs) are drugs used in clinical practice since 2009 for the prevention of stroke or systemic embolism in non-valvular atrial fibrillation, and for the treatment and secondary prevention of venous thromboembolism. The four DOACs, including the three factor Xa inhibitors (rivaroxaban, a...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Prisco D,Ageno W,Becattini C,D'Angelo A,Davì G,De Cristofaro R,Dentali F,Di Minno G,Falanga A,Gussoni G,Masotti L,Palareti G,Pignatelli P,Santi RM,Santilli F,Silingardi M,Tufano A,Violi F,SIMI (Italian Society of Inte

    更新日期:2017-04-01 00:00:00

  • Hypoadiponectinemia, cardiometabolic comorbidities and left ventricular hypertrophy.

    abstract::This study was designed to evaluate the prevalence of cardiometabolic comorbidities and the changes in left ventricular geometry and function in 135 subjects subgrouped according to low or normal total adiponectin plasma (ADPN) levels. Left ventricular (LV) internal diameter/height, total LV mass (LVM) and LVM index (...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Di Chiara T,Argano C,Scaglione A,Duro G,Corrao S,Scaglione R,Licata G

    更新日期:2015-02-01 00:00:00