Human rhinovirus 2 induces the autophagic pathway and replicates more efficiently in autophagic cells.

abstract：:BALB/c mice infected on the scarified cornea with herpes simplex virus type 1 strain 35 [HSV-1(35)] rarely developed ocular disease even at challenge doses as high as 10(7) PFU per eye. In contrast, HSV-1(RE) consistently induced stromal keratitis at an inoculum of 2 x 10(4) PFU. The goal of this study was to determin...

journal_title：Journal of virology

authors： Su YH,Oakes JE,Lausch RN

更新日期：1990-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) nucleotide sequences encoding p24Gag and the Env C2V3 region were obtained from seven patients who were selected on the basis of having paradoxical seronegativity on a subset of HIV enzyme-linked immunosorbent assay detection kits and having atypical Western blot (immunoblot...

journal_title：Journal of virology

authors： Loussert-Ajaka I,Chaix ML,Korber B,Letourneur F,Gomas E,Allen E,Ly TD,Brun-Vézinet F,Simon F,Saragosti S

更新日期：1995-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) isolates derived directly from clinical samples are usually unable to grow in cytokine-independent continuous cell lines, thus hindering the study of their biological features and their sensitivity to humoral and cellular protective immunity. To overcome these limitations, w...

journal_title：Journal of virology

authors： Lusso P,Cocchi F,Balotta C,Markham PD,Louie A,Farci P,Pal R,Gallo RC,Reitz MS Jr

更新日期：1995-06-01 00:00:00

abstract：:The avian and Nelson Bay reoviruses are two of only a limited number of nonenveloped viruses capable of inducing cell-cell membrane fusion. These viruses encode the smallest known membrane fusion proteins (p10). We now show that a region of moderate hydrophobicity we call the hydrophobic patch (HP), present in the sma...

journal_title：Journal of virology

authors： Shmulevitz M,Epand RF,Epand RM,Duncan R

更新日期：2004-03-01 00:00:00

abstract：:Numerous deaths of koi and common carp (Cyprinus carpio) were observed on many farms throughout Israel, resulting in severe financial losses. The lethal viral disease observed is highly contagious and extremely virulent, but morbidity and mortality are restricted to koi and common carp populations. Diseased fish exhib...

journal_title：Journal of virology

authors： Hutoran M,Ronen A,Perelberg A,Ilouze M,Dishon A,Bejerano I,Chen N,Kotler M

更新日期：2005-02-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) Tat protein, which is essential for HIV gene expression and viral replication, is known to mediate pleiotropic effects on various cell functions. For instance, Tat protein is able to regulate the rate of transcription of host cellular genes and to interact with the signa...

journal_title：Journal of virology

authors： Calzado MA,Sancho R,Muñoz E

更新日期：2004-07-01 00:00:00

abstract：:In 1997, an H5N1 influenza virus outbreak occurred in chickens in Hong Kong, and the virus was transmitted directly to humans. Because there is limited information about the avian influenza virus reservoir in that region, we genetically characterized virus strains isolated in Hong Kong during the 1997 outbreak. We seq...

journal_title：Journal of virology

authors： Hoffmann E,Stech J,Leneva I,Krauss S,Scholtissek C,Chin PS,Peiris M,Shortridge KF,Webster RG

更新日期：2000-07-01 00:00:00

abstract：:During ϕX174 morphogenesis, 240 copies of the external scaffolding protein D organize 12 pentameric assembly intermediates into procapsids, a reaction reconstituted in vitro In previous studies, ϕX174 strains resistant to exogenously expressed dominant lethal D genes were experimentally evolved. Resistance was achieve...

journal_title：Journal of virology

authors： Cherwa JE Jr.,,Tyson J,Bedwell GJ,Brooke D,Edwards AG,Dokland T,Prevelige PE,Fane BA

更新日期：2016-12-16 00:00:00

abstract：:The genome of the simian virus 40 (SV40) temperature-sensitive (ts) mutant tsD202 rescued by passage on transformed permissive monkey lines (see accompanying paper [Y. Gluzman et al., J. Virol. 24:534-540, 1977]) was analyzed by restriction endonuclease cleavage mapping to obtain biochemical evidence that the rescue o...

journal_title：Journal of virology

authors： Vogel T,Gluzman Y,Winocour E

更新日期：1977-11-01 00:00:00

abstract：:GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely wi...

journal_title：Journal of virology

authors： Takenouchi N,Jones KS,Lisinski I,Fugo K,Yao K,Cushman SW,Ruscetti FW,Jacobson S

更新日期：2007-02-01 00:00:00

abstract：:Two major DNA variants have been isolated from serially propagated stocks of the WR strain of vaccinia virus. Restriction enzyme mapping of the two variants with HindIII, AvaI, XhoI, SstII, and SmaI revealed a 6.3-megadalton deletion in the smaller DNA variant. The deletion was mapped at ca. 6.8 megadaltons in from th...

journal_title：Journal of virology

authors： Panicali D,Davis SW,Mercer SR,Paoletti E

更新日期：1981-03-01 00:00:00

abstract：:Production of a vesicular stomatitis virus spike protein G (VSVG)-pseudotyped lentiviral expression vector in HEK293 cells decreased on overexpression of low-density lipoprotein receptor (LDLR) but not that of ICAM1 or TfR1. Reverse transcription-quantitative PCR (RT-qPCR) revealed a reduction in vector RNA as a funct...

journal_title：Journal of virology

authors： Otahal A,Fuchs R,Al-Allaf FA,Blaas D

更新日期：2015-11-01 00:00:00

abstract：:The entry of the viral genomic DNA of cauliflower mosaic virus into the nucleus is a critical step of viral infection. We have shown by transient expression in plant protoplasts that the viral coat protein (CP), which is processed from the product of open reading frame IV, contains an N-terminal nuclear localization s...

journal_title：Journal of virology

authors： Leclerc D,Chapdelaine Y,Hohn T

更新日期：1999-01-01 00:00:00

abstract：:The nucleoprotein (NP) of influenza B virus is 50 amino acids longer at the N-terminus than influenza A virus NP and lacks homology to the A virus protein over the first 69 residues. We have deleted the N-terminal 51 and 69 residues of the influenza B/Ann Arbor/1/66 virus NP and show that nuclear accumulation of the p...

journal_title：Journal of virology

authors： Stevens MP,Barclay WS

更新日期：1998-06-01 00:00:00

abstract：:The human papillomavirus 1 (HPV-1) virion is composed of two virally encoded proteins: a 57,000-molecular-weight polypeptide (57K polypeptide), which is the product of the L1 open reading frame (ORF), and a 78K polypeptide, which is derived from the L2 ORF. The 57K (L1) product, which represents the major structural c...

journal_title：Journal of virology

authors： Doorbar J,Gallimore PH

更新日期：1987-09-01 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) expresses IE86, IE72, IE55, and IE18 mRNA by differential splicing. Reverse transcription-PCR with IE72-specific primers generated an 0.65-kb cDNA from HCMV-infected fibroblast RNA, which does not correspond to any known MIE cDNA. Nucleotide sequenci...

journal_title：Journal of virology

authors： Shirakata M,Terauchi M,Ablikim M,Imadome K,Hirai K,Aso T,Yamanashi Y

更新日期：2002-04-01 00:00:00

abstract：:It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infection efficiency. Here, we show that cytosolic plasmid DNA activates the cGAS/STING signaling pathway, which ultimately leads to the induction of an antiviral state of the cells. Using a transient one-plasmid clustered reg...

journal_title：Journal of virology

authors： Langereis MA,Rabouw HH,Holwerda M,Visser LJ,van Kuppeveld FJ

更新日期：2015-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：:The herpesvirus tegument is a layer of viral and cellular proteins located between the capsid and envelope of the virion. The VP1/2 tegument protein is critical for the propagation of all herpesviruses examined. Using an infectious clone of the alphaherpesvirus pseudorabies virus, we have made a collection of truncati...

journal_title：Journal of virology

authors： Lee JI,Luxton GW,Smith GA

更新日期：2006-12-01 00:00:00

abstract：:The E5 protein of human papillomavirus type 16 is a small, hydrophobic protein that localizes predominantly to membranes of the endoplasmic reticulum (ER). To define the orientation of E5 in these membranes, we employed a differential, detergent permeabilization technique that makes use of the ability of low concentra...

journal_title：Journal of virology

authors： Krawczyk E,Suprynowicz FA,Sudarshan SR,Schlegel R

更新日期：2010-02-01 00:00:00

abstract：UNLABELLED:To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) regulatory protein ICP0 promotes viral gene expression and replication, we screened cells overexpressing ICP0 for ICP0-binding host cell proteins. Tandem affinity purification of transiently expressed ICP0 coupled with mass spe...

journal_title：Journal of virology

authors： Sato Y,Kato A,Maruzuru Y,Oyama M,Kozuka-Hata H,Arii J,Kawaguchi Y

更新日期：2016-01-06 00:00:00

abstract：:To analyze intrauterine transmission, MT-2 cells, a human T-cell line producing human T-cell leukemia virus type I (HTLV-I), were injected into eight pregnant F344 rats, and cesarean section was performed at day 23 of pregnancy. HTLV-I provirus was detected by PCR in the liver and spleen taken from one of the eight fe...

journal_title：Journal of virology

authors： Hori M,Ami Y,Kushida S,Kobayashi M,Uchida K,Abe T,Miwa M

更新日期：1995-02-01 00:00:00

abstract：:More often than not, analyses of virus evolution have considered that virus populations are so large that evolution can be explained by purely deterministic models. However, virus populations could have much smaller effective numbers than the huge reported census numbers, and random genetic drift could be important in...

journal_title：Journal of virology

authors： Sacristán S,Malpica JM,Fraile A,García-Arenal F

更新日期：2003-09-01 00:00:00

abstract：:Vaccinia virus (VACV) stimulates long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (mousepox [ectromelia virus {ECTV}]) despite the lack of a natural host-pathogen relationship with either of these species. Previous research revealed that VACV is able to induce polyfunc...

journal_title：Journal of virology

authors： Hersperger AR,Siciliano NA,Eisenlohr LC

更新日期：2012-07-01 00:00:00

abstract：:To identify essential host genes affecting replication of Tomato bushy stunt virus (TBSV), a small model plant virus, we screened 800 yeast genes present in the yeast Tet promoters Hughes Collection. In total, we have identified 30 new host genes whose down-regulation either increased or decreased the accumulation of ...

journal_title：Journal of virology

authors： Jiang Y,Serviene E,Gal J,Panavas T,Nagy PD

更新日期：2006-08-01 00:00:00

abstract：:It was recently shown that the 7a protein of severe acute respiratory syndrome coronavirus induces biochemical changes associated with apoptosis. In this study, the mechanism by which the 7a protein induces apoptosis was examined. The 7a protein was tested for the ability to inhibit cellular gene expression because se...

journal_title：Journal of virology

authors： Kopecky-Bromberg SA,Martinez-Sobrido L,Palese P

更新日期：2006-01-01 00:00:00

abstract：:All hepadnaviruses known so far have a very limited host range, restricted to their natural hosts and a few closely related species. This is thought to be due mainly to sequence divergence in the large envelope protein and species-specific differences in host components essential for virus propagation. Here we report ...

journal_title：Journal of virology

authors： Prassolov A,Hohenberg H,Kalinina T,Schneider C,Cova L,Krone O,Frölich K,Will H,Sirma H

更新日期：2003-02-01 00:00:00

abstract：:The natural life cycle of alphaviruses, a group of plus-strand RNA viruses, involves transmission to vertebrate hosts via mosquitoes. Chronic infections are established in mosquitoes (and usually in mosquito cell cultures), but infection of susceptible vertebrate cells typically results in rapid shutoff of host mRNA t...

journal_title：Journal of virology

authors： Frolov I,Agapov E,Hoffman TA Jr,Prágai BM,Lippa M,Schlesinger S,Rice CM

更新日期：1999-05-01 00:00:00

abstract：:Superinfection exclusion is the ability of an established viral infection to interfere with a second viral infection. Using West Nile virus (WNV) as a model, we show that replicating replicons in BHK-21 cells suppress subsequent WNV infection. The WNV replicon also suppresses superinfections of other flaviviruses but ...

journal_title：Journal of virology

authors： Zou G,Zhang B,Lim PY,Yuan Z,Bernard KA,Shi PY

更新日期：2009-11-01 00:00:00

abstract：:In adenovirus-infected cells, the epidermal growth factor receptor (EGF-R) is internalized from the cell surface via endosomes and is degraded, and the E3 10,400-dalton protein (10.4K protein) is required for this effect (C. R. Carlin, A. E. Tollefson, H. A. Brady, B. L. Hoffman, and W. S. M. Wold, Cell 57:135-144, 19...

journal_title：Journal of virology

authors： Tollefson AE,Stewart AR,Yei SP,Saha SK,Wold WS

更新日期：1991-06-01 00:00:00