Abstract：
:Conventional ultrasound imaging is based on the scattering of sound from inhomogeneities in the density and the speed of sound and is often used in medicine to resolve pathologic compared to normal tissue. Here we demonstrate a difference-frequency ultrasound (dfUS) imaging method that is based on the interaction of two sound pulses that propagate non-collinearly and intersect in space and time. The dfUS signal arises primarily from the second-order non-linear coefficient, a contrast mechanism that differs from linear and harmonic US imaging. The distinct contrast mechanism allows dfUS to image anatomic features that are not identifiable in conventional US images of salmon and pig kidney tissue. Further, dfUS produces enhanced contrast of glioblastoma tumor implanted in the mouse brain, revealing its potential for improving medical diagnosis. Progress towards a real-time system is discussed.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Li Y,Polyak D,Johnson E,Yecies D,Shevidi S,de la Zerda A,Gephart MH,Chu Sdoi
10.1109/TMI.2019.2957280subject
Has Abstractpub_date
2020-05-01 00:00:00pages
1759-1766issue
5eissn
0278-0062issn
1558-254Xjournal_volume
39pub_type
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