Abstract：
:An analysis of the kinetics of myocardial contrast enhancement is an important component of myocardial perfusion studies. The contrast enhancement can be modeled by a linear time-invariant system, and the myocardial impulse response, calculated by deconvolution of the measured tissue response with an arterial input, gives a direct estimate of myocardial blood flow. In this paper, we analyze the effects of delays in the contrast enhancement, that occur in collateral-dependent myocardium, where the tracer reaches the tissue region only through branches from other coronary arteries that form natural bypass vessels. We investigate how the delayed arrival of tracer alters the myocardial impulse response. Model-independent deconvolution is applied to determine the lag between arterial input and tissue enhancement. Experimental data in a porcine model of collateral development indicate that the delayed arrival of an injected tracer, measured at rest, is a useful marker to identify collateral-dependent myocardium, and predict its flow capacitance.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Jerosch-Herold M,Hu X,Murthy NS,Seethamraju RTdoi
10.1109/TMI.2004.827969subject
Has Abstractpub_date
2004-07-01 00:00:00pages
881-90issue
7eissn
0278-0062issn
1558-254Xjournal_volume
23pub_type
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