Twenty Clinically Pertinent Factors/Observations for Percutaneous Absorption in Humans.

abstract：:Ocular diseases associated with atopic dermatitis (AD) may be sight-threatening. A general understanding of the pathophysiology, diagnosis, and treatment of atopic eye disease may assist dermatologists in knowing when to refer to ophthalmology and in co-managing these diseases with ophthalmologists. Ocular diseases as...

journal_title：American journal of clinical dermatology

authors： Beck KM,Seitzman GD,Yang EJ,Sanchez IM,Liao W

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Methotrexate (MTX) is an effective treatment for psoriasis but its use is limited by its toxicity. Folate supplementation can be used to reduce the adverse effects of MTX, though this may impact efficacy. The frequency of folic acid supplementation is not well characterized. PURPOSE:The objective of this st...

journal_title：American journal of clinical dermatology

authors： Al-Dabagh A,Davis SA,Kinney MA,Huang K,Feldman SR

更新日期：2013-06-01 00:00:00

abstract：:After a marked decline in the number of syphilis cases in the context of AIDS prevention campaigns, a significant increase has been observed in states of the former Soviet Union since 1994. In recent years, outbreaks have also been reported in the US, Canada, and several European countries. The current epidemic in the...

journal_title：American journal of clinical dermatology

authors： Lautenschlager S

更新日期：2006-01-01 00:00:00

abstract：:Tildrakizumab (tildrakizumab-asmn in the USA) [Ilumetri®; Ilumya™] is a humanized monoclonal antibody (mAb) that selectively targets the p19 subunit of interleukin (IL)-23, thereby inhibiting the IL-23/IL-17 axis, the signalling pathway primarily implicated in the immunopathogenesis of psoriasis. Administered subcutan...

journal_title：American journal of clinical dermatology

authors： Frampton JE

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Many dermatologic disorders are known to adversely affect quality of life (QoL) in close relatives or partners of patients; however, it is unknown whether vitiligo impacts the QoL of family members. OBJECTIVE:The aim of this study was to identify the level and domains in which the QoL of partners/relatives ...

journal_title：American journal of clinical dermatology

authors： Bin Saif GA,Al-Balbeesi AO,Binshabaib R,Alsaad D,Kwatra SG,Alzolibani AA,Yosipovitch G

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is an allergic disorder caused by both immunological dysregulation and epidermal barrier defect. Several studies have investigated the association between AD and mental health disorders. Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental conditions characte...

journal_title：American journal of clinical dermatology

authors： Billeci L,Tonacci A,Tartarisco G,Ruta L,Pioggia G,Gangemi S

更新日期：2015-10-01 00:00:00

abstract：:Granuloma annulare (GA) is a chronic inflammatory disease of unknown etiology characterized by the development of plaques preferentially localized to the distal extremities. Spontaneous remission and relapses are quite common and the course of GA is not easy to predict. Moreover, most therapeutic regimens have been us...

journal_title：American journal of clinical dermatology

authors： Murdaca G,Colombo BM,Barabino G,Caiti M,Cagnati P,Puppo F

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Videodermatoscopy is a non-invasive technique that allows in vivo skin observation at high magnifications. OBJECTIVE:The goal of this study was to determine if videodermatoscopy enhances diagnostic capability beyond standard clinical observation in three series of patients: one group of patients with overt ...

journal_title：American journal of clinical dermatology

authors： Lacarrubba F,Dall'Oglio F,Rita Nasca M,Micali G

更新日期：2004-01-01 00:00:00

abstract：:Seborrheic dermatitis (SD) is characterized by erythematous pruritic patches and plaques with greasy scale that occur in sebaceous areas. It is common, affecting up to 3% of the population. Past treatments have relied on a wide variety of anti-inflammatory and antifungal agents, but corticosteroids have limited use be...

journal_title：American journal of clinical dermatology

authors： Cook BA,Warshaw EM

更新日期：2009-01-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) has been proposed as a treatment for toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). A comprehensive search of the literature was conducted to examine the efficacy and safety of IVIg in TEN and SJS patients. Seventeen relevant articles (14 TEN, 3 SJS) were identif...

journal_title：American journal of clinical dermatology

authors： Mittmann N,Chan B,Knowles S,Cosentino L,Shear N

更新日期：2006-01-01 00:00:00

abstract：:Granular parakeratosis (GP) is a rare, idiopathic, and benign skin condition that presents classically as erythematous to brown hyperkeratotic papules that can coalesce into plaques. Axillary GP was initially observed by Northcutt and colleagues and has since been described in various other areas of the body including...

journal_title：American journal of clinical dermatology

authors： Ding CY,Liu H,Khachemoune A

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:A few studies in psoriasis vulgaris patients have reported changes suggesting red blood cell (RBC) damage is linked to neutrophil activation, oxidative stress, and psoriasis worsening. OBJECTIVE:The aim of this study was to evaluate erythroid disturbances in Portuguese psoriasis vulgaris patients, before, d...

journal_title：American journal of clinical dermatology

authors： Coimbra S,Oliveira H,Reis F,Belo L,Rocha S,Quintanilha A,Figueiredo A,Teixeira F,Castro E,Rocha-Pereira P,Santos-Silva A

更新日期：2012-02-01 00:00:00

abstract：:We provide a guide for dermatologists to follow if they encounter patients with a rash and clinical history suspicious of Zika virus infection, including diagnostic testing and management options. We also provide an illustrative case report of a patient from Brazil who was diagnosed with Zika virus infection after pre...

journal_title：American journal of clinical dermatology

authors： He A,Brasil P,Siqueira AM,Calvet GA,Kwatra SG

更新日期：2017-04-01 00:00:00

abstract：:Diagnosing acne is easy. However, treatment must be adapted to the type and severity of acne, and must also take into account the impact of acne on patients' quality of life. As there is not always a correlation between the severity of acne and its impact on quality of life, it can be helpful for the dermatologist to ...

journal_title：American journal of clinical dermatology

authors： Dréno B

更新日期：2006-01-01 00:00:00

abstract：:Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder characterized by scarring alopecia of the scalp and eyebrows in the setting of widespread keratosis pilaris. Less frequent associations are ocular abnormalities and palmoplantar keratoderma. Acne keloidalis nuchae has previously been described in ...

journal_title：American journal of clinical dermatology

authors： Janjua SA,Iftikhar N,Pastar Z,Hosler GA

更新日期：2008-01-01 00:00:00

abstract：:Mycobacterial organisms have re-emerged as an important cause of infectious disease worldwide. Both tuberculosis and nontuberculous mycobacterial infections remain endemic in many parts of the world and are becoming more common in patients with iatrogenic immunosuppression and HIV infection. The nontuberculous mycobac...

journal_title：American journal of clinical dermatology

authors： Elston D

更新日期：2009-01-01 00:00:00

abstract：:Rituximab is a chimeric monoclonal antibody that selectively binds to the CD20 molecule on B cells, resulting in their lysis. In autoimmune blistering diseases, the auto-antibody-producing B cells are destroyed and auto-antibody levels are reduced or eliminated. In the majority of patients, rituximab produces rapid cl...

journal_title：American journal of clinical dermatology

authors： Ahmed AR,Shetty S

更新日期：2015-06-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a severe chronic autoimmune blistering disease that affects the skin and mucous membranes. It is characterized by suprabasal acantholysis due to disruption of desmosomal connections between keratinocytes. Autoantibodies against desmosomal cadherins, desmoglein 3 and 1, have been shown to ind...

journal_title：American journal of clinical dermatology

authors： Altman EM

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Topical coal tar is a well known and effective treatment for psoriasis, but the messiness, staining, odor, and inconvenience associated with its use make patient satisfaction and compliance a challenge. OBJECTIVE:To determine the efficacy, patient tolerability, and cosmetic acceptability of a new topical li...

journal_title：American journal of clinical dermatology

authors： Alora-Palli MB,Perkins AC,Van Cott A,Kimball AB

更新日期：2010-01-01 00:00:00

abstract：:Immunotherapy has revolutionized the treatment of melanoma. Targeting of the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 has led to improved survival in a subset of patients. Unfortunately, the use of immune checkpoint inhibitors is associated with significant sid...

journal_title：American journal of clinical dermatology

authors： Rizk EM,Seffens AM,Trager MH,Moore MR,Geskin LJ,Gartrell-Corrado RD,Wong W,Saenger YM

更新日期：2020-02-01 00:00:00

abstract：:A recent study demonstrated an association between psoriasis and dilated cardiomyopathy. Tumour necrosis factor alpha (TNFalpha) may be involved in the pathogenesis of dilated cardiomyopathy and therefore, anti-TNFalpha agents may play a role in the treatment of dilated cardiomyopathy. The case of a 51-year-old woman ...

journal_title：American journal of clinical dermatology

authors： De Simone C,Carbone A,Caldarola G

更新日期：2010-01-01 00:00:00

abstract：:Aging of the skin is associated with skin thinning, atrophy, dryness, wrinkling, and delayed wound healing. These undesirable aging effects are exacerbated by declining estrogen levels in postmenopausal women. With the rise in interest in long-term postmenopausal skin management, studies on the restorative benefits th...

journal_title：American journal of clinical dermatology

authors： Shu YY,Maibach HI

更新日期：2011-10-01 00:00:00

abstract：:Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any age, including children. If not treated, it has the potential to cause significant and permanent scarring and deformity of the vulvar structure. In addition, if untreated, i...

journal_title：American journal of clinical dermatology

authors： Lee A,Fischer G

更新日期：2018-10-01 00:00:00

abstract：:Occupational contact dermatitis (OCD) represents 90 to 95% of all occupational dermatoses. The incidence rate of OCD is estimated to be around 0.5 to 1.9 cases per full-time worker per year. However, epidemiologic data are lacking and incidence is probably underestimated, especially in the US. Over the past 20 years, ...

journal_title：American journal of clinical dermatology

authors： Koch P

更新日期：2001-01-01 00:00:00

abstract：SIGNIFICANCE:Psoriasis, a common immune-mediated disease, affects approximately 2% of the population worldwide. Sudden sensorineural hearing loss (SSNHL) might be a manifestation of systemic vascular involvement in autoimmune disease. However, to the best of our knowledge, there is no systematic English-language examin...

journal_title：American journal of clinical dermatology

authors： Yen YC,Lin YS,Weng SF,Lai FJ

更新日期：2015-06-01 00:00:00

abstract：:Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...

journal_title：American journal of clinical dermatology

authors： Li W,Yosipovitch G

更新日期：2020-09-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous tumor with a predilection for the head and neck of elderly Caucasian patients. Although much less common than melanoma, MCC has higher rates of sentinel lymph node involvement, local and regional recurrences, and mortality. The majority of MCC cases have b...

journal_title：American journal of clinical dermatology

authors： Brummer GC,Bowen AR,Bowen GM

更新日期：2016-02-01 00:00:00

abstract：:Uncommon types of cutaneous cancers are mainly cited in the literature as case reports and their etiology, pathogenesis and prognosis have to be surmised because of their rarity. Within this group exist the rare and also the unusual, for instance a relatively common carcinoma arising in a strange circumstance. Initial...

journal_title：American journal of clinical dermatology

authors： Topping A,Wilson GR

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association. METHODS:We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case-control, cross-sectional, and cohort studies examining the assoc...

journal_title：American journal of clinical dermatology

authors： Yen H,Chi CC

更新日期：2019-02-01 00:00:00

abstract：:Topical pimecrolimus 1% cream (Elidel) [hereafter referred to as topical pimecrolimus] is a nonsteroidal alternative in the treatment of pediatric atopic dermatitis. In vehicle-controlled, short-term, continuous-use trials in pediatric patients with mild to moderate atopic dermatitis, topical pimecrolimus was effectiv...

journal_title：American journal of clinical dermatology

authors： Yang LP,Curran MP

更新日期：2010-01-01 00:00:00