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Landscape and Regulation of m6A and m6Am Methylome across Human and Mouse Tissues.

Abstract：

:N6-methyladenosine (m6A), the most abundant internal mRNA modification, and N6,2'-O-dimethyladenosine (m6Am), found at the first-transcribed nucleotide, are two reversible epitranscriptomic marks. However, the profiles and distribution patterns of m6A and m6Am across human and mouse tissues are poorly characterized. Here, we report the m6A and m6Am methylome through profiling of 43 human and 16 mouse tissues and demonstrate strongest tissue specificity for the brain tissues. A small subset of tissue-specific m6A peaks can also readily classify tissue types. The overall m6A and m6Am level is partially correlated with the expression level of their writers and erasers. Additionally, the m6A-containing regions are enriched for SNPs. Furthermore, cross-species analysis revealed that species rather than tissue type is the primary determinant of methylation. Collectively, our study provides an in-depth resource for dissecting the landscape and regulation of the m6A and m6Am epitranscriptomic marks across mammalian tissues.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Liu J,Li K,Cai J,Zhang M,Zhang X,Xiong X,Meng H,Xu X,Huang Z,Peng J,Fan J,Yi C

doi

10.1016/j.molcel.2019.09.032

subject

Has Abstract

pub_date

2020-01-16 00:00:00

pages

426-440.e6

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(19)30758-0

journal_volume

77

pub_type

杂志文章

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