Abstract:
:The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is made possible by the reversal of effects of negative elongation factors that include NELF and DSIF. In complex organisms, elongation control is critical for the regulated expression of most genes. In those organisms, the function of P-TEFb is influenced negatively by HEXIM proteins and 7SK snRNA and positively by a variety of recruiting factors. Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns.
journal_name
Mol Celljournal_title
Molecular cellauthors
Peterlin BM,Price DHdoi
10.1016/j.molcel.2006.06.014subject
Has Abstractpub_date
2006-08-04 00:00:00pages
297-305issue
3eissn
1097-2765issn
1097-4164pii
S1097-2765(06)00429-1journal_volume
23pub_type
杂志文章,评审相关文献
MOLECULAR CELL文献大全abstract::ComS is an antiadaptor protein that binds to MecA, displacing the competence transcription factor ComK. This protects ComK from degradation by the ClpCP protease and turns on the switch leading to bistable gene expression. Here we identify the motifs on ComK and ComS that mediate binding to MecA, and we show that they...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.05.011
更新日期:2007-06-08 00:00:00
abstract::In a recent issue of Molecular Cell, Shiotani and Zou (2009) elucidate the biochemical mechanism underlying sequential ATM and ATR activation at DNA double-strand breaks, demonstrating that resection transforms ATM substrates into ATR substrates. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.03.004
更新日期:2009-03-27 00:00:00
abstract::B and T cell receptor gene assembly by V(D)J recombination is tightly regulated during lymphoid development. The mechanisms involved in this regulation are poorly understood. Here we show that nucleosomal DNA is refractory to V(D)J cleavage. However, the presence of HMG1, a chromatin-associated nonhistone DNA-binding ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)80297-x
更新日期:1998-12-01 00:00:00
abstract::The membrane-spanning C-terminal regions in tail-anchored proteins must be recognized and delivered posttranslationally to the endoplasmic reticulum or mitochondrial membrane. A paper in this issue of Molecular Cell (Wang et al., 2010) and another recent report (Mariappan et al., 2010) delineate early steps in this pa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.09.016
更新日期:2010-10-08 00:00:00
abstract::In this issue of Molecular Cell, Hogues et al. (2008) demonstrate a wholesale shift in the key regulatory protein involved in ribosomal protein (RP) synthesis during the evolution of S. cerevisiae and, en passant, raise interesting questions about the relationship between RP genes and telomeres. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.02.008
更新日期:2008-03-14 00:00:00
abstract::Brr2 is a unique DExD/H box protein required for catalytic activation and disassembly of the spliceosome. It contains two tandem helicase cassettes that both comprise dual RecA-like domains and a noncanonical Sec63 unit. The latter may bestow the enzyme with unique properties. We have determined crystal structures of ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.08.006
更新日期:2009-08-28 00:00:00
abstract::The control of mRNA stability plays a central role in regulating gene expression. In metazoans, the earliest stages of development are driven by maternally supplied mRNAs. The degradation of these maternal mRNAs is critical for promoting the maternal-to-zygotic transition of developmental programs, although the underl...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.02.027
更新日期:2016-03-17 00:00:00
abstract::Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(02)00584-1
更新日期:2002-07-01 00:00:00
abstract::The C-terminal fragment, Bb, of factor B combines with C3b to form the pivotal C3-convertase, C3bBb, of alternative complement pathway. Bb consists of a von Willebrand factor type A (vWFA) domain that is structurally similar to the I domains of integrins and a serine protease (SP) domain that is in inactive conformati...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(04)00160-1
更新日期:2004-04-09 00:00:00
abstract::The disulfide relay system in the intermembrane space of mitochondria is of crucial importance for mitochondrial biogenesis. Major players in this pathway are the oxidoreductase Mia40 that oxidizes substrates and the sulfhydryl oxidase Erv1 that reoxidizes Mia40. To analyze in detail the mechanism of this oxidative pa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.01.017
更新日期:2010-02-26 00:00:00
abstract::We have used gene competition to distinguish between possible mechanisms of transcriptional activation of the genes of the human beta-globin locus. The insertion of a second beta-globin gene at different points in the locus shows that the more proximal beta gene competes more effectively for activation by the locus co...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)80014-3
更新日期:1997-12-01 00:00:00
abstract::FGF and other Ras/MAPK pathway activators counterbalance BMP action during neurogenesis, bone formation, and other aspects of vertebrate development and homeostasis. BMP receptors signal through C-terminal phosphorylation and nuclear translocation of the transcription factor Smad1, whereas MAPKs catalyze inhibitory ph...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.01.006
更新日期:2007-02-09 00:00:00
abstract::The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3beta, forms a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of beta-catenin by the proteasome. Siah-1, the human homolog of Drosophila seven in absentia, is a p53-inducible mediator of cell c...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(01)00241-6
更新日期:2001-05-01 00:00:00
abstract::During muscle regeneration, the mechanism integrating environmental cues at the chromatin of muscle progenitors is unknown. We show that inflammation-activated MKK6-p38 and insulin growth factor 1 (IGF1)-induced PI3K/AKT pathways converge on the chromatin of muscle genes to target distinct components of the muscle tra...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.08.021
更新日期:2007-10-26 00:00:00
abstract::Ubiquitin-mediated proteolysis regulates the activity of diverse receptor systems. Here, we identify Smurf2, a C2-WW-HECT domain ubiquitin ligase and show that Smurf2 associates constitutively with Smad7. Smurf2 is nuclear, but binding to Smad7 induces export and recruitment to the activated TGF beta receptor, where i...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)00134-9
更新日期:2000-12-01 00:00:00
abstract::Three introns whose splicing is activated during meiosis in S. cerevisiae contain a Mer1p-dependent splicing enhancer. The enhancer can impose Mer1p-activated splicing upon the constitutively spliced actin intron provided the basal splicing efficiency of actin is first reduced. Of several nonessential splicing factors...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)00033-2
更新日期:2000-08-01 00:00:00
abstract::The Rictor/mTOR complex (also known as mTORC2) plays a critical role in cellular homeostasis by phosphorylating AGC kinases such as Akt and SGK at their hydrophobic motifs to activate downstream signaling. However, the regulation of mTORC2 and whether it has additional function(s) remain largely unknown. Here, we repo...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.08.016
更新日期:2010-09-10 00:00:00
abstract::Eukaryotic protein kinases are generally classified as being either tyrosine or serine-threonine specific. Though not evident from inspection of their primary sequences, many serine-threonine kinases display a significant preference for serine or threonine as the phosphoacceptor residue. Here we show that a residue lo...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.11.013
更新日期:2014-01-09 00:00:00
abstract::Signals transmitted by ERK MAP kinases regulate the functions of multiple substrates present in the nucleus and in the cytoplasm. ERK signals are optimized by scaffold proteins that modulate their intensity and spatial fidelity. Once phosphorylated, ERKs dimerize, but how dimerization impacts on the activation of the ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.07.024
更新日期:2008-09-05 00:00:00
abstract::c-Jun, a major transcription factor in the activating protein 1 (AP-1) family of regulatory proteins, is activated by many physiologic and pathologic stimuli. However, whether c-jun is regulated by epigenetic modification of chromatin structure is not clear. We showed here that c-jun was transcriptionally repressed in...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.01.005
更新日期:2007-01-26 00:00:00
abstract::Macroautophagy (autophagy) is a lysosome-dependent degradation process that has been implicated in age-associated diseases. Autophagy is involved in both cell survival and cell death, but little is known about the mechanisms that distinguish its use during these distinct cell fates. Here, we identify the microRNA miR-...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2014.09.011
更新日期:2014-11-06 00:00:00
abstract::The structural diversity of glycans on cells-the glycome-is vast and complex to decipher. Glycan arrays display oligosaccharides and are used to report glycan hapten binding epitopes. Glycan arrays are limited resources and present saccharides without the context of other glycans and glycoconjugates. We used maps of g...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2019.05.017
更新日期:2019-07-25 00:00:00
abstract::The glycogen synthase kinase-3 (GSK3) family kinases are central cellular regulators highly conserved in all eukaryotes. In Arabidopsis, the GSK3-like kinase BIN2 phosphorylates a range of proteins to control broad developmental processes, and BIN2 is degraded through unknown mechanism upon receptor kinase-mediated br...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2017.05.012
更新日期:2017-06-01 00:00:00
abstract::The double Holliday junction (dHJ) is generally regarded to be a key intermediate of meiotic recombination, whose resolution is critical for the formation of crossover recombinants. In fission yeast, the Mus81-Eme1 endonuclease has been implicated in resolving dHJs. Consistent with this role, we show that Mus81-Eme1 i...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00343-5
更新日期:2003-09-01 00:00:00
abstract::The mechanisms by which telomeres are distinguished from DNA double-strand breaks are poorly understood. Here we have defined the minimal requirements for the protection of telomeric DNA ends from nonhomologous end-joining (NHEJ). Neither long, single-stranded overhangs nor t loop formation is essential to prevent NHE...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.03.023
更新日期:2007-05-11 00:00:00
abstract::Actin-related proteins (Arps) and conventional actin are enigmatic components of many chromatin-remodeling enzyme complexes. The yeast INO80 ATP-dependent chromatin-remodeling complex contains stoichiometric amounts of Arp4, Arp5, Arp8, and actin. Here we have revealed functions of Arp5 and Arp8 by analysis of mutants...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00264-8
更新日期:2003-07-01 00:00:00
abstract::The DNA polymerase from phage phi29 is a B family polymerase that initiates replication using a protein as a primer, attaching the first nucleotide of the phage genome to the hydroxyl of a specific serine of the priming protein. The crystal structure of phi29 DNA polymerase determined at 2.2 A resolution provides expl...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2004.10.019
更新日期:2004-11-19 00:00:00
abstract::Polyubiquitination is a posttranslational modification where ubiquitin chains containing isopeptide bonds linking one of seven ubiquitin lysines with the C terminus of an adjoining ubiquitin are covalently attached to proteins. While functions of K48- and K63-linked polyubiquitin are understood, the role(s) of noncano...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.07.001
更新日期:2010-08-13 00:00:00
abstract::Plus-end tracking proteins, such as EB1 and the dynein/dynactin complex, regulate microtubule dynamics. These proteins are thought to stabilize microtubules by forming a plus-end complex at microtubule growing ends with ill-defined mechanisms. Here we report the crystal structure of two plus-end complex components, th...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2005.06.034
更新日期:2005-08-19 00:00:00
abstract::Metazoan spliceosomes exhibit an elaborate protein composition required for canonical and alternative splicing. Thus, the minimal set of proteins essential for activation and catalysis remains elusive. We therefore purified in vitro assembled, precatalytic spliceosomal complex B, activated B(act), and step 1 complex C...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.09.040
更新日期:2009-11-25 00:00:00