SIRTing through breast cancer is just a survivin' game.


:Loss of endogenous tumor suppression is a critical step on the road to cancer. In a recent paper in Molecular Cell, Wang and colleagues provide evidence that inactivation of the pivotal BRCA1 tumor suppressor disrupts a safeguard gene network that opposes cell proliferation and cell survival.


Mol Cell


Molecular cell


Luo J,Altieri DC




Has Abstract


2008-10-24 00:00:00














  • A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase.

    abstract::A kinase-anchoring proteins (AKAPs) target PKA to specific microdomains by using an amphipathic helix that docks to N-terminal dimerization and docking (D/D) domains of PKA regulatory (R) subunits. To understand specificity, we solved the crystal structure of the helical motif from D-AKAP2, a dual-specific AKAP, bound...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Kinderman FS,Kim C,von Daake S,Ma Y,Pham BQ,Spraggon G,Xuong NH,Jennings PA,Taylor SS

    更新日期:2006-11-03 00:00:00

  • Spindle assembly factor protection.

    abstract::In this issue, Song et al. (2014) describe how microtubules and the RAN GTPase/importin-β system collaborate to control timing of HURP action and its turnover via the anaphase promoting complex (APC)-proteasome system, thereby ensuring temporal control of late mitotic events. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Vaites LL,Harper JW

    更新日期:2014-01-23 00:00:00

  • Modulation of RNA polymerase assembly dynamics in transcriptional regulation.

    abstract::The interaction of transcription factors with target genes is highly dynamic. Whether the dynamic nature of these interactions is merely an intrinsic property of transcription factors or serves a regulatory role is unknown. Here we have used single-cell fluorescence imaging combined with computational modeling and chr...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Gorski SA,Snyder SK,John S,Grummt I,Misteli T

    更新日期:2008-05-23 00:00:00

  • FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.

    abstract::The Fanconi anemia (FA) pathway is implicated in DNA repair and cancer predisposition. Central to this pathway is the FA core complex, which is targeted to chromatin by FANCM and FAAP24 following replication stress. Here we show that FANCM and FAAP24 interact with the checkpoint protein HCLK2 independently of the FA c...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Collis SJ,Ciccia A,Deans AJ,Horejsí Z,Martin JS,Maslen SL,Skehel JM,Elledge SJ,West SC,Boulton SJ

    更新日期:2008-11-07 00:00:00

  • Different aa-tRNAs are selected uniformly on the ribosome.

    abstract::Ten E. coli aminoacyl-tRNAs (aa-tRNAs) were assessed for their ability to decode cognate codons on E. coli ribosomes by using three assays that evaluate the key steps in the decoding pathway. Despite a wide variety of structural features, each aa-tRNA exhibited similar kinetic and thermodynamic properties in each assa...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Ledoux S,Uhlenbeck OC

    更新日期:2008-07-11 00:00:00

  • Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed?

    abstract::Defective ER-resident membrane proteins need to be ejected into the cytoplasm in order to be degraded by the proteasome, but the exact mechanism remains unclear. In this issue of Molecular Cell, Neal et al. (2018) reveal that the rhomboid pseudoprotease Dfm1 defines the central ERAD component for membrane protein disl...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Avci D,Lemberg MK

    更新日期:2018-01-18 00:00:00

  • Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.

    abstract::Growing resistance of pathogenic bacteria and shortage of antibiotic discovery platforms challenge the use of antibiotics in the clinic. This threat calls for exploration of unconventional sources of antibiotics and identification of inhibitors able to eradicate resistant bacteria. Here we describe a different class o...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Pantel L,Florin T,Dobosz-Bartoszek M,Racine E,Sarciaux M,Serri M,Houard J,Campagne JM,de Figueiredo RM,Midrier C,Gaudriault S,Givaudan A,Lanois A,Forst S,Aumelas A,Cotteaux-Lautard C,Bolla JM,Vingsbo Lundberg C,Huseby

    更新日期:2018-04-05 00:00:00

  • A global profile of germline gene expression in C. elegans.

    abstract::We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new componen...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Reinke V,Smith HE,Nance J,Wang J,Van Doren C,Begley R,Jones SJ,Davis EB,Scherer S,Ward S,Kim SK

    更新日期:2000-09-01 00:00:00

  • Involvement of transcription termination factor 2 in mitotic repression of transcription elongation.

    abstract::All nuclear transcription is interrupted during mitosis. We examined the role of human TTF2, an RNA polymerase (Pol) I and II termination factor, in mitotic repression of transcription elongation. We find that TTF2 levels rise in the cytoplasm in S and G2 and at the onset of mitosis TTF2 translocates into the nucleus....

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Jiang Y,Liu M,Spencer CA,Price DH

    更新日期:2004-05-07 00:00:00

  • VASA mediates translation through interaction with a Drosophila yIF2 homolog.

    abstract::The Drosophila gene vasa (vas) encodes an RNA-binding protein required for embryonic patterning and germ cell specification. In vas mutants, translation of several germline mRNAs is reduced. Here we show that VAS interacts directly with the Drosophila homolog of yeast translation initiation factor 2, encoded by a nove...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Carrera P,Johnstone O,Nakamura A,Casanova J,Jäckle H,Lasko P

    更新日期:2000-01-01 00:00:00

  • RIP3 induces apoptosis independent of pronecrotic kinase activity.

    abstract::Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three selective small-molecule compounds are shown to inhibit RIP3 kinase-dependent necroptosis, although their therapeutic value is undermined by a surpris...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Mandal P,Berger SB,Pillay S,Moriwaki K,Huang C,Guo H,Lich JD,Finger J,Kasparcova V,Votta B,Ouellette M,King BW,Wisnoski D,Lakdawala AS,DeMartino MP,Casillas LN,Haile PA,Sehon CA,Marquis RW,Upton J,Daley-Bauer LP,

    更新日期:2014-11-20 00:00:00

  • Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

    abstract::SPT5 and its binding partner SPT4 function in both positively and negatively regulating transcriptional elongation. The demonstration that SPT5 and RNA polymerase II are targets for phosphorylation by CDK9/cyclin T1 indicates that posttranslational modifications of these factors are important in regulating the elongat...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Kwak YT,Guo J,Prajapati S,Park KJ,Surabhi RM,Miller B,Gehrig P,Gaynor RB

    更新日期:2003-04-01 00:00:00

  • Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions.

    abstract::DNA replication forks pause in front of lesions on the template, eventually leading to cytotoxic chromosomal rearrangements. The in vivo structure of damaged eukaryotic replication intermediates has been so far elusive. Combining electron microscopy (EM) and two-dimensional (2D) gel electrophoresis, we found that UV-i...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Lopes M,Foiani M,Sogo JM

    更新日期:2006-01-06 00:00:00

  • The response regulator BvgA and RNA polymerase alpha subunit C-terminal domain bind simultaneously to different faces of the same segment of promoter DNA.

    abstract::Examination of the binding of FeBABE-conjugated BvgA to the fha promoter of Bordetella pertussis has revealed that three dimers, formed by head-to-head association of monomers, bind one face of the DNA helix from the inverted-heptad primary binding site to the -35 region. The orientation of BvgA monomers within the di...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Boucher PE,Maris AE,Yang MS,Stibitz S

    更新日期:2003-01-01 00:00:00

  • Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells.

    abstract::Triplex structure-forming GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity. Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia disease in humans. In model systems, long GAA/TTC tracts also act as chromosomal fragile sites that can trigger gross chromosomal re...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Zhang Y,Shishkin AA,Nishida Y,Marcinkowski-Desmond D,Saini N,Volkov KV,Mirkin SM,Lobachev KS

    更新日期:2012-10-26 00:00:00

  • Functional splicing network reveals extensive regulatory potential of the core spliceosomal machinery.

    abstract::Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the effect of knocking down the components of the splicing machinery on alternative splicing events rel...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Papasaikas P,Tejedor JR,Vigevani L,Valcárcel J

    更新日期:2015-01-08 00:00:00

  • A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

    abstract::Cell pattern in the ventral neural tube is organized by Sonic hedgehog (Shh) secreted by floor plate cells. To assay the range of direct Shh action, we developed a general method for blocking transduction of Hedgehog (Hh) signals through ectopic expression of a deleted form of the Hh receptor Patched (Ptc), termed Ptc...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Briscoe J,Chen Y,Jessell TM,Struhl G

    更新日期:2001-06-01 00:00:00

  • Engineering biological systems with synthetic RNA molecules.

    abstract::RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory, information processing, and scaff...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Liang JC,Bloom RJ,Smolke CD

    更新日期:2011-09-16 00:00:00

  • Gene repression by coactivator repulsion.

    abstract::We show that the IRF-2 oncoprotein represses virus-induced IFN-beta gene transcription via a novel mechanism. Virus infection induces recruitment of IRF-2 to some of the endogenous IFN-beta enhancers as part of the enhanceosome. Enhanceosomes bearing IRF-2 cannot activate transcription, due to the presence of a domain...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Senger K,Merika M,Agalioti T,Yie J,Escalante CR,Chen G,Aggarwal AK,Thanos D

    更新日期:2000-10-01 00:00:00

  • Not just because it is there: aminoacyl-tRNA synthetases gain control of the cell.

    abstract::In a recent issue of Molecular Cell, Jia et al. (2008) demonstrate that time-controlled repression of interferon-induced transcripts depends upon the interaction between an RNA structure in these transcripts and protein domains harbored by a mammalian aminoacyl-tRNA synthetase. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Ribas de Pouplana L,Geslain R

    更新日期:2008-04-11 00:00:00

  • Herpes simplex virus glycoprotein D bound to the human receptor HveA.

    abstract::Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Carfí A,Willis SH,Whitbeck JC,Krummenacher C,Cohen GH,Eisenberg RJ,Wiley DC

    更新日期:2001-07-01 00:00:00

  • Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.

    abstract::tRNAs are subject to numerous modifications, including methylation. Mutations in the human N7-methylguanosine (m7G) methyltransferase complex METTL1/WDR4 cause primordial dwarfism and brain malformation, yet the molecular and cellular function in mammals is not well understood. We developed m7G methylated tRNA immunop...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Lin S,Liu Q,Lelyveld VS,Choe J,Szostak JW,Gregory RI

    更新日期:2018-07-19 00:00:00

  • Unlocking the proteasome door.

    abstract::How proteasomal ATPases stimulate the gate opening of 20S proteasomes is a longstanding question. In the September 7 issue of Molecular Cell, Smith et al. (2007) describe the conserved "HbYX" motif as the key to proteasome gate opening. ...

    journal_title:Molecular cell

    pub_type: 评论,杂志文章


    authors: Saeki Y,Tanaka K

    更新日期:2007-09-21 00:00:00

  • Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen.

    abstract::ER-associated degradation (ERAD) of glycoproteins depends on dual recognition of protein misfolding and remodeling of the substrate's N-linked glycans. After recognition, substrates are retrotranslocated to the cytosol for proteasomal degradation. To explore the directionality of this process, we fused a highly stable...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Bhamidipati A,Denic V,Quan EM,Weissman JS

    更新日期:2005-09-16 00:00:00

  • Autoinhibition of Bcr-Abl through its SH3 domain.

    abstract::Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil domain that disrupt ...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Smith KM,Yacobi R,Van Etten RA

    更新日期:2003-07-01 00:00:00

  • RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage.

    abstract::Ubiquitin modification of proteins plays pivotal roles in the cellular response to DNA damage. Given the complexity of ubiquitin conjugation due to the formation of poly-conjugates of different linkages, functional roles of linkage-specific ubiquitin modification at DNA damage sites are largely unclear. We identify th...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Paul A,Wang B

    更新日期:2017-05-18 00:00:00

  • The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone.

    abstract::Baculoviral IAP repeat proteins (BIRPs) may affect cell death, cell division, and tumorigenesis. The C. elegans BIRP BIR-1 was localized to chromosomes and to the spindle midzone. Embryos and fertilized oocytes lacking BIR-1 had defects in chromosome behavior, spindle midzone formation, and cytokinesis. We observed in...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Speliotes EK,Uren A,Vaux D,Horvitz HR

    更新日期:2000-08-01 00:00:00

  • Organelle-Specific Initiation of Autophagy.

    abstract::Autophagy constitutes a prominent mechanism through which eukaryotic cells preserve homeostasis in baseline conditions and in response to perturbations of the intracellular or extracellular microenvironment. Autophagic responses can be relatively non-selective or target a specific subcellular compartment. At least in ...

    journal_title:Molecular cell

    pub_type: 杂志文章,评审


    authors: Sica V,Galluzzi L,Bravo-San Pedro JM,Izzo V,Maiuri MC,Kroemer G

    更新日期:2015-08-20 00:00:00

  • SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

    abstract::Zinc is an essential trace element, and impaired zinc homeostasis is implicated in the pathogenesis of various human diseases. However, the mechanisms cells use to respond to zinc deficiency are poorly understood. We previously reported that amyotrophic lateral sclerosis (ALS)-linked pathogenic mutants of SOD1 cause c...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Homma K,Fujisawa T,Tsuburaya N,Yamaguchi N,Kadowaki H,Takeda K,Nishitoh H,Matsuzawa A,Naguro I,Ichijo H

    更新日期:2013-10-10 00:00:00

  • Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

    abstract::Posttranslational modification with small ubiquitin-related modifier (SUMO) has emerged as a central regulatory mechanism of protein function. However, little is known about the regulation of sumoylation itself. It has been reported that it is increased after exposure to various stresses including strong oxidative str...

    journal_title:Molecular cell

    pub_type: 杂志文章


    authors: Bossis G,Melchior F

    更新日期:2006-02-03 00:00:00