Abstract:
:This investigation was designed to assess the potential use of laser coronary angioplasty as an intraoperative adjunct in the surgical treatment of ischemic heart disease. Among 17 postmortem hearts, simulated laser coronary angioplasty was performed at 53 sites with a No. 4F guiding catheter and 240 micron (200 micron core) quartz optical fiber. Perforation complicated laser coronary angioplasty in 33 (62%) of the 53 attempts. Most (n = 29) perforations were thermal; four were purely mechanical. Perforation sites were characterized by extensive calcific deposits (21 of 33 cases [64%] ) and the origin of a side branch (13 of 33 [39%] ). Excessive tortuosity of the extramural coronary artery contributed to arterial perforation in four cases, and precluded attempts to perform laser coronary angioplasty in two other cases. In 19 of the 53 attempts to perform laser coronary angioplasty, a high-frequency two-dimensional echocardiographic probe was used to image the coronary artery during antegrade manipulation of the optical fiber/guiding catheter and laser irradiation of the target arterial stenosis. Although perforation nevertheless occurred in 11 (58%) of 19 sites, only one mechanical perforation resulted; the remaining 10 were thermal. Characteristics of the perforation sites in this group were similar to those noted for the group as a whole. Experience with this model of laser coronary angioplasty indicates that even when access problems associated with percutaneous laser coronary angioplasty are obviated by a simulated intraoperative approach, perforation of the underlying coronary arterial wall continues to represent the "rate-limiting" complication of laser coronary angioplasty. Most perforations occurred in relation to calcific deposits, branch points, and tortuous coronary segments.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Circulationjournal_title
Circulationauthors
Isner JM,Donaldson RF,Funai JT,Deckelbaum LI,Pandian NG,Clarke RH,Konstam MA,Salem DN,Bernstein JSsubject
Has Abstractpub_date
1985-09-01 00:00:00pages
II191-9issue
3 Pt 2eissn
0009-7322issn
1524-4539journal_volume
72pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::This study was conducted in 46 patients with cardiac thrombi, 15 patients with atrial myxomas, and 32 patients with other cardiac or paracardiac tumors. Diagnoses were subsequently proven by surgery, autopsy, computed tomography, magnetic resonance imaging, or angiography in all patients. All patients underwent precor...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.83.1.70
更新日期:1991-01-01 00:00:00
abstract::Common conditions predisposing to atherosclerosis, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with endothelial dysfunction. Endothelial function has largely been assessed as endothelium-dependent vasomotion, at least in part based on the assumption that impaired endothelium-depen...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000129501.88485.1f
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Although hepatocyte growth factor (HGF), a novel angiogenic growth factor, plays an important role in angiogenesis, regulation of local HGF production under hypoxia has not yet been clarified in vascular smooth muscle cells (VSMC) and endothelial cells (EC). Thus, we have studied the role of HGF in hypoxia-i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.suppl_2.ii-301
更新日期:1999-11-09 00:00:00
abstract:BACKGROUND:The overall performance of available mechanical intravascular ultrasound catheters for fetal transesophageal echocardiography during fetoscopic fetal cardiac interventions in sheep has been limited by radioelectronic interference, low system frame rates, and low acoustic outputs. Therefore, a more reliable d...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc4001.097937
更新日期:2001-10-09 00:00:00
abstract:BACKGROUND:Current knowledge of prevalence, incidence, and survival in thoracic aortic diseases (aneurysm and dissection) is based on small studies from a dated era of treatment and diagnostic procedures. The objective of the present study was to reappraise epidemiology and long-term outcomes in subjects with thoracic ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.630400
更新日期:2006-12-12 00:00:00
abstract:BACKGROUND:The purpose of this study was to describe a new technique for catheter ablation of left lateral accessory pathways (APs) by radiofrequency energy applied at the epicardium through the coronary sinus wall using a unipolar configuration. METHODS AND RESULTS:In an overall group of 212 patients with left latera...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.5.1464
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Vascular injury and atherothrombosis involve vessel infiltration by inflammatory leukocytes, migration of medial vascular smooth muscle cells to the intimal layer, and ultimately acute thrombosis. A strategy to simultaneously target these pathological processes has yet to be identified. The secreted protein,...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.112.105452
更新日期:2012-09-11 00:00:00
abstract:BACKGROUND:Mendelian randomization studies have highlighted that lipoprotein(a) [Lp(a)] was associated with calcific aortic valve disease (CAVD). Lp(a) transports oxidized phospholipids with a high content in lysophosphatidylcholine. Autotaxin (ATX) transforms lysophosphatidylcholine into lysophosphatidic acid. We hypo...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.115.016757
更新日期:2015-08-25 00:00:00
abstract::Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurren...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.59.2.412
更新日期:1979-02-01 00:00:00
abstract::The electrophysiologic effects of intravenously administered disopyramide (2 mg/kg) on three parameters of sinus node function were examined in 16 symptomatic patients with sinus node dysfunction. Based on their ECG data before study, patients were subdivided into group A (n = 8), those with sinus pauses and/or sinoat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.59.2.226
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Few data exist regarding the effects of angiotensin converting enzyme inhibitors in patients with regurgitant valvular lesions. We postulated an immediate improvement in cardiac performance with captopril in mitral regurgitation, which, in a hemodynamically compensated group of patients, might be mediated th...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.5.2049
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol. This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.0000016173.98826.88
更新日期:2002-04-23 00:00:00
abstract::From 1962-1977, 99 patients, mean age 65 +/- 0.5 years (range 60-81 years) underwent valve replacement for severe calcific aortic valve stenosis. Ninety-three percent of the patients were in New York Heart Association functional class III or IV. The aortic valve gradient was 76 +/- 3 mm Hg and the aortic valve area in...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:Patients with a non-ST-elevation acute coronary syndrome and prior CABG are at high risk of a recurrent ischemic event despite aspirin therapy. This trial investigated the potential benefit of secondary prevention with warfarin. METHODS AND RESULTS:In a double-blind randomized trial, 135 patients with unsta...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.103.25.3069
更新日期:2001-06-26 00:00:00
abstract:BACKGROUND:Current two-dimensional echocardiographic measures of right ventricular volume are limited by the asymmetrical and crescentic shape of the ventricle and by difficulty in obtaining standardized views. Three-dimensional echocardiographic reconstruction, which does not require geometric assumptions or standardi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.5.2342
更新日期:1994-05-01 00:00:00
abstract::Sustained-release diltiazem (D-SR) and sustained-release verapamil (V-SR) when given twice a day have been successfully used to treat both essential hypertension and angina pectoris. Review of available studies indicates that 120 to 180 mg D-SR twice a day and 240 mg V-SR once or twice a day can lower diastolic pressu...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1987-06-01 00:00:00
abstract::After a change in cardiac output, the magnitude of potential blood volume redistribution was investigated in 10 dogs anesthetized with chloralose. All of the venous return was pumped into a reservoir, using servocontrolled pumps to maintain fixed superior and inferior vena cava pressures. The cardiac output was set at...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.1.360
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Although clopidogrel is used to prevent subacute stent thrombosis, its safety and efficacy have not been compared with ticlopidine in a randomized manner in the United States. METHODS AND RESULTS:Patients with successful intracoronary stent implantation were randomly assigned to therapy with ticlopidine or ...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/hc3001.093435
更新日期:2001-07-31 00:00:00
abstract:BACKGROUND:If drug refractoriness to paroxysmal atrial fibrillation (PAF) occurs, arrhythmia surgery that involves channelling and the exclusion of specific atrial areas can abolish atrial fibrillation. The purpose of this study was to establish the effectiveness and safety of maze III surgery to abolish PAF. METHODS ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.13.1559
更新日期:2000-04-04 00:00:00
abstract::Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abno...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.118.036259
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain. METHODS AND RESULTS:We analyzed data from a prospective cohort of 754 patients with heart failure who had ejection fractio...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000116764.53225.A9
更新日期:2004-03-02 00:00:00
abstract:BACKGROUND:The high cardiovascular morbidity and mortality in patients with end-stage kidney disease could be partially caused by extensive cardiovascular calcification. SNF472, intravenous myo-inositol hexaphosphate, selectively inhibits the formation and growth of hydroxyapatite. METHODS:This double-blind, placebo-c...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.119.044195
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:It has been suggested that intracellular Ca2+ overload in cardiac myocytes leads to the development of diabetic cardiomyopathy. Troglitazone, an insulin-sensitizing agent, is a promising therapeutic agent for diabetes and has been shown to prevent diabetes-induced myocardial changes. To elucidate the underly...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.22.2942
更新日期:1999-06-08 00:00:00
abstract:BACKGROUND:Diagnostic strategies with ECG and serum cardiac markers have been used to rule out acute myocardial infarction in 6 to 12 hours. The present study evaluated whether a multimarker strategy that used point-of-care measurement of myoglobin, creatine kinase (CK)-MB, and troponin I could exclude acute myocardial...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc3801.096336
更新日期:2001-09-25 00:00:00
abstract:BACKGROUND:Recurrent cerebrovascular events constitute an estimated 200,000 of the 700,000 strokes reported annually in the United States, which makes secondary stroke prevention an important goal in the management of disease among patients who have experienced stroke or transient ischemic attack. METHODS AND RESULTS:...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.106.653741
更新日期:2007-03-27 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is an important active protein for the induction of angiogenesis and improvement in cardiac function after myocardial ischemia; however, the lack of a delivery system targeted to the injured myocardium reduces the local therapeutic efficacy of VEGF and increases its ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.800565
更新日期:2009-04-07 00:00:00
abstract:BACKGROUND:We determined the intraclass correlation coefficients (ICC) of repeated measures of the mean levels and variability of RR and muscle sympathetic nerve activity (MSNA) in 7 normal subjects. We examined whether spontaneous fluctuations in RR and MSNA over repeated measurements were mirrored by changes in spect...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.12.4326
更新日期:1997-12-16 00:00:00
abstract:BACKGROUND:Distal embolization of debris during percutaneous carotid artery stenting may result in neurological deficit. Filter devices for cerebral protection potentially reduce the risk of embolization. METHODS AND RESULTS:Elective carotid stent implantation using 3 different types of distal filter protection device...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/hc2601.092495
更新日期:2001-07-03 00:00:00
abstract:BACKGROUND:It is unknown whether the appropriate use of percutaneous coronary intervention (PCI) has improved over time and whether trends in PCI appropriateness have been accompanied by changes in the use of PCI. METHODS AND RESULTS:We applied appropriate use criteria to determine the appropriateness of all 51 872 PC...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.015156
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. METHODS:We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their rel...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.035012
更新日期:2019-02-05 00:00:00