Abstract：
OBJECTIVE:Low circulating levels of testosterone have been associated with major depression, but there is more limited evidence for differences in patients with anxiety disorders. The use of selective serotonin reuptake inhibitors (SSRIs) and other antidepressants is associated with sexual side effects, warranting testing for interactions with testosterone. METHODS:Data are from 722 male and 1380 female participants of The Netherlands Study of Depression and Anxiety (NESDA), who were recruited from the community, general practice care, and specialized mental health care. Depressive and anxiety diagnoses were assessed using the DSM-IV Composite International Diagnostic Interview. To smooth the episodic secretion, the four morning saliva samples per participant and the two evening samples were pooled before testosterone analysis. RESULTS:Morning median testosterone levels were 25.2 pg/ml in men and 16.2 pg/ml in women, with lower evening levels of 18.2 and 14.1 pg/ml, respectively. Significant determinants of testosterone levels were sex, age, time of the day, use of contraceptives, and smoking status. Female patients with a current (1-month) depressive disorder (effect size 0.29; P=0.002), generalized anxiety disorder (0.25; P=0.01), social phobia (0.30; P<0.001), and agoraphobia without panic disorder (0.30; P=0.02) had lower salivary testosterone levels than female controls. Higher testosterone levels were found in male and female participants using SSRIs than in non-users (effect size 0.26; P<0.001). CONCLUSION:Salivary testosterone levels are lower in female patients with a depressive disorder, generalized anxiety disorder, social phobia, and agoraphobia as compared to female controls. SSRIs may increase salivary testosterone in men and women.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Giltay EJ,Enter D,Zitman FG,Penninx BW,van Pelt J,Spinhoven P,Roelofs Kdoi
10.1016/j.jpsychores.2011.11.014subject
Has Abstractpub_date
2012-03-01 00:00:00pages
205-13issue
3eissn
0022-3999issn
1879-1360pii
S0022-3999(11)00306-0journal_volume
72pub_type
杂志文章abstract：OBJECTIVE:Pain and prescription opioid medication use are prevalent and a major source of psychological and physical health burden. This research examines whether Five Factor Model personality traits prospectively predict who will experience persistent pain and use prescription opioid medication over a 10-year follow-u...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.04.019
更新日期：2019-08-01 00:00:00
abstract：:Substantial numbers of patients suffer from chronic back pain without demonstrating identifiable organic pathology of the spine. Since standardized methods of assessing psychological disturbances (e.g. MMPI) in such patients often provoke hostility and resentment, a questionnaire (BPCS) was developed which employs ver...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(86)90002-4
更新日期：1986-01-01 00:00:00
abstract：:Due to the fact that oral contraceptives (OCs) can alter the pain threshold and since evidence of possible concomitant changes in the cardiovascular response to pain is still missing, an investigation of the response of heart rate (HR), blood pressure (BP), and systolic time interval (STI) to ischemic pain in OC users...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(81)90113-6
更新日期：1981-01-01 00:00:00
abstract：:Psychological responses to a diagnosis of breast cancer, assessed three months post operatively, are related to outcome 10 yr after operation. These results confirm the findings previously reported at 5 yr. The need for further study into the nature of the reported psychological response categories and the likely medi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(84)90066-7
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:Depression is a significant issue for young people with physical disabilities. Efficient and reliable questionnaires are needed to evaluate and monitor the efficacy of depression treatments in this population. The aim of this study was to evaluate the reliability and validity of the 10-item version of the Chi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2016.09.007
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hostility may be associated with greater systemic inflammation. However, contradictory evidence exists. Certain individuals or dimensions of hostility may be more susceptible to these effects. Main and interactive effects of hostility with sex and/or age were evaluated on markers of inflammatio...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.02.010
更新日期：2014-05-01 00:00:00
abstract：:Stress reduction programs (SRPs) can reduce morbidity and mortality in patients with coronary artery disease (CAD). This study evaluated the effect of an SRP on metabolic and hormonal risk factors for CAD. Twenty army officers participating in an SRP, Group I, and a comparison group of seventeen SRP nonparticipants, G...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(93)90136-4
更新日期：1993-05-01 00:00:00
abstract：OBJECTIVE:Depressive symptoms are common after liver transplantation (LT). We studied whether depressive symptoms affect long-term survival after LT. METHODS:In a prospective cohort study, 134 liver transplant patients were assessed for depressive symptoms using the Beck Depression Inventory-short form (BDI), focusing...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.12.008
更新日期：2011-07-01 00:00:00
abstract：:Four patients who had suffered a myocardial infarction were given biofeedback training in order to assess (1) the possibility of increasing heart rate variability with the help of a feedback; (2) the possible cardiac consequences, from the clinical viewpoint, of biofeedback treatment. A biofeedback procedure alternate...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章
doi：10.1016/0022-3999(82)90086-1
更新日期：1982-01-01 00:00:00
abstract：:This study investigated whether the level of somatic complaint increases as men make the supposedly stressful passage from work to retirement. For 171 retirees, pre- to post-retirement changes in the sum of selected somatic complaints from the Cornell Medical Index were compared with changes over a comparable time int...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(83)90110-1
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to summarize the available literature on the effectiveness of ambulatory nurse-led case management for complex patients in general health care. METHOD:We searched MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and Cinahl. We included randomized controlled trials, controll...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2006.10.015
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:Mental fatigability refers to the failure to sustain participation in tasks requiring mental effort. Older adults with vascular risk are at particular risk for experiencing mental fatigability. The present study (1) tested a new way of measuring objective mental fatigability by examining its association with...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.04.001
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:Diagnostic screening for functional neurological disorders (FNDs) continues to pose a challenge. Simple symptom counts fail clearly to discriminate patients with FND but there is increasing recognition of 'positive' features which are useful diagnostically during face-to-face assessments. A self-completed que...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.02.005
更新日期：2019-04-01 00:00:00
abstract：:The effect of exercise training on quality of life and exercise capacity was studied in 67 patients with mild to moderate chronic heart failure (CHF; age: 65.6+/-8.3 years; left ventricular ejection fraction: 26.5+/-9.6%). Patients were randomly allocated to either a training group or to a control group. After interve...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0022-3999(97)00309-7
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVE:Phantom bite syndrome (PBS) is characterized by a persistent uncomfortable sensation of occlusion without an evident occlusal discrepancy. The aims of this retrospective cross-sectional study were to assess psychiatric comorbidities and evaluate psychopharmacological outcomes of PBS. METHODS:The database of ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.11.010
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:The analysis of clinical trials in delirium is typically complicated by treatment dropouts and by the fact that even untreated individuals may have a good prognosis. These features of delirium trials warrant special statistical attention; implications for each stage of a trial planning process are described. ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.06.002
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:The objectives were to give an overview of studies on the validity of the Toronto Alexithymia Scale (TAS-20) and to present data regarding the validity of the TAS-20. METHODS:The literature on the psychometric properties of the TAS-20 was reviewed and a study was conducted of its psychometric properties in a...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/s0022-3999(02)00348-3
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:The relationship between resting-state heart rate variability (HRV) and somatic symptom disorder (SSD) has been explored in several studies. We planned to examine HRV during the performance of psychological tasks, and assumed that it could be applied for the diagnosis of SSD. METHODS:Fifty-three patients wit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.05.007
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:The 'psychogenic' hypothesis has a long history in the field of infertility. The present study investigated whether anxiety or depressive symptoms are associated with probability of subsequent live birth in a cohort of infertile women from the general population. METHODS:Using linked data from 12,987 women i...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.07.001
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Chronic fatigue syndrome (CFS) is characterized by profound fatigue accompanied by disturbances of sleep, cognition, mood, and other symptoms. Our objective was to describe sleep architecture in CFS-discordant twin pairs. METHODS:We conducted a co-twin control study of 22 pairs of monozygotic twins where one t...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/S0022-3999(03)00598-1
更新日期：2004-02-01 00:00:00
abstract：:A decreased sensitivity to painful stimuli and high scores for alexithymia and depression have been observed in patients with eating disorders. We investigated the relationship between these factors in 22 patients with anorexia nervosa, 18 patients with bulimia nervosa, and 32 healthy subjects. Alexithymia was assesse...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(96)00088-8
更新日期：1996-07-01 00:00:00
abstract：:Chronic fatigue syndrome (CFS) is a poorly understood condition. Possible etiological factors include infectious agents, psychiatric disorders, and personality characteristics. We examined personality dimensions in 30 nondepressed patients with CFS, 20 patients with major depressive disorder (MDD), and 15 healthy cont...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章
doi：10.1016/s0022-3999(98)00120-2
更新日期：1999-04-01 00:00:00
abstract：PURPOSE:The aim of this study was to examine the illness beliefs and locus of control of patients with recent onset pseudoseizures and to compare these with patients with recent onset epilepsy. METHODS:Twenty consecutive patients with pseudoseizures of recent onset (mean duration 5.4 months) were compared with 20 cons...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2004.03.013
更新日期：2004-12-01 00:00:00
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journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(95)00613-3
更新日期：1996-04-01 00:00:00
abstract：:This study investigates the function of the hypothalamic-pituitary-adrenal (HPA)-axis and the availability of L-tryptophan and tyrosine to the brain in postpartum women and in women taking long-term oral contraceptives. To this end, we have measured the following parameters in 50 women (i.e. 9 normal controls, 10 wome...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(92)90028-z
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:In this cross-sectional pilot study of couples in whom the man was diagnosed with prostate cancer or the woman with breast cancer, the purpose was to identify and compare the variables that characterize couples where both spouses are in high psychological distress with couples where the psychological distress...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(03)00502-6
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:To date, most research on perceived discrimination and cardiovascular disease (CVD) has examined racial discrimination although other forms of discrimination may also impact physical and mental health. The current study investigated the relationship between three forms of discrimination (weight, race, and gen...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2017.07.007
更新日期：2017-09-01 00:00:00
abstract：:From experience, most people know about a link between psychological processes and gastrointestinal sensory and motor functions. Cognitive processes (e.g., attention) as well as affective processes (e.g., fear) play a role in gastrointestinal sensations in healthy controls and patients with irritable bowel syndrome (I...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2008.02.018
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:Physical complaints such as faintness, dizziness, cold limbs and headaches have been well-established in chronic low blood pressure (hypotension). This study investigated the occurrence of adverse emotional states and the symptoms of depression in this condition. As autonomic dysregulation, particularly dimin...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2016.12.008
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:Childhood sexual abuse (CSA) has an estimated prevalence of 20% and has a constantly growing list of known long-term consequences on physical as well as psychological health which may also influence obstetrical care attributed to it. However, scientific data on the association of CSA and pregnancy are sparse....
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.04.017
更新日期：2010-11-01 00:00:00
