Abstract:
:Leishmania are obligatory intracellular parasitic protozoa that cycle between sand fly mid-gut and phagolysosomes of mammalian macrophages. They have developed genetically programmed changes in gene and protein expression that enable rapid optimization of cell function according to vector and host environments. During the last two decades, host-free systems that mimic intra-lysosomal environments have been devised in which promastigotes differentiate into amastigotes axenically. These cultures have facilitated detailed investigation of the molecular mechanisms underlying Leishmania development inside its host. Axenic promastigotes and amastigotes have been subjected to transcriptome and proteomic analyses. Development had appeared somewhat variable but was revealed by proteomics to be strictly coordinated and regulated. Here we summarize the current understanding of Leishmania promastigote to amastigote differentiation, highlighting the data generated by proteomics.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Tsigankov P,Gherardini PF,Helmer-Citterich M,Zilberstein Ddoi
10.1017/S0031182012000157subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1146-57issue
9eissn
0031-1820issn
1469-8161pii
S0031182012000157journal_volume
139pub_type
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