Experimental study on inhibition of rat ventricular Ik1 by RNA interference targeting the KCNJ2 gene.

abstract：:The aim of this study was to explore the value of contrast-enhanced ultrasound (CEUS) in differentiating small renal masses. A total of 102 small renal masses (≤ 3 cm) in 99 patients were examined using conventional ultrasound (CUS) and CEUS, and the findings were reviewed and evaluated in comparison to pathology. Sig...

journal_title：Bioscience trends

authors： Chen L,Wang L,Diao X,Qian W,Fang L,Pang Y,Zhan J,Chen Y

更新日期：2015-08-01 00:00:00

abstract：:Aster yomena (Kitam.) Honda has been widely used as a traditional herbal medicine for centuries to treat cough, asthma, insect bites, etc. Recent reports indicate that A. yomena possesses a wide spectrum of pharmacological activities; however, few experiments have described its anti-inflammatory properties. The presen...

journal_title：Bioscience trends

authors： Kang HJ,Jeong JS,Park NJ,Go GB,Kim SO,Park C,Kim BW,Hong SH,Choi YH

更新日期：2017-03-22 00:00:00

abstract：:The aim of the current study was to investigate the effects of FL118, a novel camptothecin analogue, on migration and invasion of human breast cancer cells and the underlying mechanisms of those effects. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and a plate clone formation assay we...

journal_title：Bioscience trends

authors： Yang Z,Ji L,Jiang G,Liu R,Liu Z,Yang Y,Ma Q,Zhao H

更新日期：2018-01-01 00:00:00

abstract：:Laparoscopic liver resection (LLR) has garnered attention as a new form of liver surgery. In China, many hepatobiliary surgeons are now encouraging the examination and assessment of LLC in order to improve its outcomes, and several young hepatobiliary surgeons recently shared their clinical experiences and the results...

journal_title：Bioscience trends

authors： Zhao X,Song P,Zhang Y,Huang J

更新日期：2018-01-01 00:00:00

abstract：:Atrazine (ATR), one of the most widely used herbicides worldwide, has caused a series of toxicological and environmental problems. This study sought to investigate the effects of ATR on the immune system of mice. Four-week-old female C57B l/6 mice were treated with 5, 25, and 125 mg/kg ATR for 28 days. On day 29, bloo...

journal_title：Bioscience trends

authors： Zhao S,Liu J,Zhao F,Liu W,Li N,Suo Q,Zhao J,Zhao L

更新日期：2013-08-01 00:00:00

abstract：:As is similar to glial cell line-derived neurotrophic factor (GDNF), the Yangjing Capsule (YC) extract could also lead to proliferation of spermatogonial stem cells (SSCs) by stimulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway; however, the regulatory effect of YC extract on the expression ...

journal_title：Bioscience trends

authors： Jin B,Cai B,Sun D,Zhang X,Cui Y,Deng W,Gao C

更新日期：2017-03-22 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) has become a public health problem worldwide. Hormonal replacement therapy (HRT) is the most popular treatment for PMO at present, but the side effects, including increased risk of endometrial cancer and breast cancer, limit its clinical use. Therefore, finding a new medication with h...

journal_title：Bioscience trends

authors： Wu S,Zhao F,Zhao J,Li H,Chen J,Xia Y,Wang J,Zhao B,Zhao S,Li N

更新日期：2019-11-13 00:00:00

abstract：:Precise diagnosis is a key measurement for malaria control and elimination, traditional microscopy and rapid diagnostic tests cannot satisfy the requirements especially in the low transmission endemic areas or in the malaria elimination phase. Polymerase chain reaction (PCR) with high sensitivity and specificity can b...

journal_title：Bioscience trends

authors： Yin J,Li M,Yan H,Zhou S

更新日期：2018-01-01 00:00:00

abstract：:The mortality rate of fulminant hepatic failure was high until liver transplantation was presented as a potential therapy. We encountered a patient with hyperacute fulminant hepatic failure due to hepatitis B virus infection. Living donor liver transplantation was planned but abandoned because her brain edema progress...

journal_title：Bioscience trends

authors： Takemura N,Sugawara Y,Tamura S,Kakeno J,Matsui Y,Makuuchi M

更新日期：2007-08-01 00:00:00

abstract：:Malignant mesothelioma (MM) is an insidious, lethal asbestos-related cancer that is poorly responsive to current treatments. Specific and sensitive biomarkers providing early MM diagnosis in exposed subjects, who are at high-risk of developing it, are sorely needed. MicroRNAs (miRNAs) are endogenous, non-coding, small...

journal_title：Bioscience trends

authors： Micolucci L,Rippo MR,Olivieri F,Procopio AD

更新日期：2017-03-22 00:00:00

abstract：:Transplantation with Wharton's jelly derived mesenchymal stem cells (WJ-MSCs) showed great benefits for restoring myocardial function. However, the outcome of WJ-MSCs transplantation was unsuccessful due to multiple factors including oxidative damage. The presence of oxidative stress due to myocardium injury influence...

journal_title：Bioscience trends

authors： Nimsanor N,Phetfong J,Kitiyanant N,Kamprom W,Supokawej A

更新日期：2019-11-13 00:00:00

abstract：:The emerging novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has swept across the world and become a global threat to public health. More than 200 countries and territories worldwide are suffering from this COVID-19 pandemic. Worryingly, no specific vaccine...

journal_title：Bioscience trends

authors： Dong X,Tian Z,Shen C,Zhao C

更新日期：2020-11-04 00:00:00

abstract：:Spinal cord injury (SCI) is a serious injury of the central nervous system and up until now there is no evident effective treatment for SCI. Axonal regeneration is the only way to restore functions after serious SCI that interrupt the long tracts mediating motor and sensory function. The hurdles for axonal regeneratio...

journal_title：Bioscience trends

authors： Cui X,Chen L,Ren Y,Ji Y,Liu W,Liu J,Yan Q,Cheng L,Sun YE

更新日期：2013-10-01 00:00:00

abstract：:In oocytes, many maternally supplied products are stored, and these products play important roles in cell cycle regulation and early development. Mos protein, which is coded on the c-mos gene, promotes oocyte maturation and is involved in MAP-kinase signaling pathway. In Xenopus, maternally supplied c-mos mRNA undergo...

journal_title：Bioscience trends

authors： Suzuki H,Tsukahara T,Inoue K

更新日期：2009-06-01 00:00:00

abstract：:We identified the prevalence of depression and quality of life (QOL) of Japanese children with childhood cancer after discharge using the Birleson Depression Self-rating Scale for Children (DSRS-C) and the Pediatric Quality of Life Inventory (PedsQL). Subjects were 118 caregivers who raised children ages 2-18 with chi...

journal_title：Bioscience trends

authors： Wakimizu R,Hiraga N,Furuya K,Fukushima T,Tsuchida M,Koike K,Yamamoto T

更新日期：2011-12-01 00:00:00

abstract：:Granzyme 3 (Gr3) is known as a tryptase-type member of the granzyme family and exists in the granules of immunocompetent cells. Granule proteases including granzymes, are transported into the cytoplasm of tumor cells or virus-infected cells by perforin function, degrade cytoplasmic or nuclear proteins and subsequently...

journal_title：Bioscience trends

authors： Hirata Y,Inagaki H,Shimizu T,Kawada T

更新日期：2014-04-01 00:00:00

abstract：:Complete loss of function in the WRN: RecQ3 DNA/RNA helicase gene causes Werner Syndrome (WS). WS patients with genetic instability manifest an early onset of age-related diseases including diabetes mellitus (DM), osteoporosis, atherosclerosis, and malignancy as well as early death. In 1,420 patients, WS was reported ...

journal_title：Bioscience trends

authors： Goto M

更新日期：2008-08-01 00:00:00

abstract：:In-stent restenosis is highly related to the deposition of inflammatory extracellular matrix and the migration of endothelial and vascular smooth muscle cells. The miR-17/TIMP-1/interleukin pathway regulates vascular matrix remodeling and plays an important role in the inflammatory reaction. This study identified miR-...

journal_title：Bioscience trends

authors： Jiang F,Zhang X,Lu YM,Li YG,Zhou X,Wang YS

更新日期：2019-11-13 00:00:00

abstract：:Human herpesvirus 8 (HHV8) is an important opportunistic infection of HIV/AIDS. However, very little is known about antibody seropositivities to HHV8 lytic and latent antigens among HIV-infected patients in China. Therefore, a cross-sectional study was conducted to explore HHV8 serostatus among 316 HIV-infected patien...

journal_title：Bioscience trends

authors： Zhang TJ,He N,Ding YY,Jiang QW,Wood C

更新日期：2012-06-01 00:00:00

abstract：:We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Ca...

journal_title：Bioscience trends

authors： Du Y,Huang L,Wang X,Cui Q,Cheng X,Zhao L,Ni T

更新日期：2017-09-12 00:00:00

abstract：:Catalpol is a natural iridoid glycoside with diverse bioactivities that is found in abundance in Rehmannia glutinosa Libosch. (Scrophulariaceae). The present study assessed whether catalpol treatment (5, 10, or 20 mg/kg for 14 days by intragastric administration (i.g.)) has an antidepressant-like effect on mice perfor...

journal_title：Bioscience trends

authors： Wang J,Cui Y,Feng W,Zhang Y,Wang G,Wang X,Zhou G

更新日期：2014-10-01 00:00:00

abstract：:It has been hypothesized that subjective well-being (SWB) is determined by a combination of individual characteristics, social environment, and physical environment. However, few studies have simultaneously examined the relationships of the social and physical attributes of a neighborhood with SWB. Accordingly, the pr...

journal_title：Bioscience trends

authors： Gao J,Weaver SR,Fu H,Jia Y,Li J

更新日期：2017-11-20 00:00:00

abstract：:We have recently demonstrated that unconjugated bilirubin (UCB) limits the overexpression of adhesion molecules and inhibits the PMN endothelial adhesion induced by the pro-inflammatory cytokine TNFalpha. To understand the molecular events involved we investigated whether the inhibitory effect is determined by a direc...

journal_title：Bioscience trends

authors： Mazzone GL,Rigato I,Ostrow JD,Tiribelli C

更新日期：2009-08-01 00:00:00

abstract：:The purpose of this study was to evaluate the 2-day seminar in 2 consecutive years respectively for community health professionals. We prepared the child-rearing support manual (CRSM) and conducted a seminar program to improve skills to provide mental assessments and postnatal care support for mothers and their famili...

journal_title：Bioscience trends

authors： Kamibeppu K,Furuta M,Yamashita H,Sugishita K,Suzumiya H,Yoshida K

更新日期：2009-02-01 00:00:00

abstract：:The initial processes involved in radiation carcinogenesis have not been clearly elucidated. We isolated mouse mutant cells exhibiting plasticity in their mutation phenotypes. These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in...

journal_title：Bioscience trends

authors： Yamauchi M,Fukutsu K,Sakagami M,Yamada Y

更新日期：2010-08-01 00:00:00

abstract：:Adjuvant therapy after resection of hepatocellular carcinoma (HCC) is limited. Here, we evaluated the effects of postoperative sorafenib on recurrence and survival in HCC patients. Recurrence-free survival and overall survival were analyzed as the main endpoint, recurrence rate, and mortality rate were analyzed as sec...

journal_title：Bioscience trends

authors： Zhang W,Zhao G,Wei K,Zhang Q,Ma W,Song T,Wu Q,Zhang T,Kong D,Li Q

更新日期：2014-12-01 00:00:00

abstract：:At the end of 2013, a Japanese newspaper reported that 4,173 children were unidentified or missing in Japan. The article concluded that child abuse was a matter of national concern. In examining the strengths and weaknesses of Japan's welfare system in regard to child abuse, it would seem that a weakness exists with r...

journal_title：Bioscience trends

authors： Takahashi K,Kanda H,Sugaya N

更新日期：2014-08-01 00:00:00

abstract：:The effects of anesthesia with sevoflurane and with propofol on glucose utilization in rats were investigated. Sevoflurane significantly impairs glucose utilization whereas propofol does not. Both insulin secretion and sensitivity affect glucose utilization. Propofol is hydrophobic, and anesthesia with this agent is a...

journal_title：Bioscience trends

authors： Li X,Kitamura T,Kawamura G,Mori Y,Sato K,Araki Y,Sato R,Yamada Y

更新日期：2014-06-01 00:00:00

abstract：:Cardiomyocyte nutrient deprivation is a common clinical event that mediates various cardiac ischemic processes and is associated with autophagy activation and cell survival or death. Luteolin-7-O-glucoside (LUTG) was one of the flavonoid glycosides isolated from Dracocephalum tanguticum. Previous research had showed t...

journal_title：Bioscience trends

authors： Yao H,Zhou L,Tang L,Guan Y,Chen S,Zhang Y,Han X

更新日期：2017-11-20 00:00:00

abstract：:Noninvasive prenatal testing (NIPT) is increasingly recognized and utilized in the antenatal care field. In the current study, we aimed to evaluate the clinical application and compare test outcomes of two generations of currently used NIPT techniques for detecting fetal chromosome abnormalities in a high-risk prenata...

journal_title：Bioscience trends

authors： Du Y,Lin J,Lan L,Dong Y,Zhu J,Jiang W,Pan X,Lu Y,Li D,Wang L

更新日期：2018-07-17 00:00:00