Plasma and plasma derivatives in therapeutic plasmapheresis.

Abstract:

:In therapeutic plasmapheresis, patient plasma is withdrawn and a colloid replacement solution is infused in its place. A 4% to 5% human serum albumin solution in saline is the preferred replacement solution in most instances, even though this practice causes transient mild deficiencies of most plasma proteins. Albumin solutions are pasteurized for viral inactivation, are very unlikely to cause a febrile or allergic reaction, and are convenient to store and administer. Single-donor plasma must be type specific, which requires advance knowledge of patient blood type, and must be ordered and usually thawed before use. It also carries a higher risk of reactions. On the plus side, it replaces all plasma constituents and is appropriate for patients with thrombotic thrombocytopenic purpura or an existing coagulopathy. Neither cryosupernatant plasma, which is relatively deficient in the proteins in cryoprecipitate, nor plasma derived from pools that have been virally inactivated with detergents and organic solvents has been shown to produce better outcomes than fresh frozen plasma for any indication.

journal_name

Transfusion

journal_title

Transfusion

authors

McLeod BC

doi

10.1111/j.1537-2995.2012.03623.x

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

38S-44S

eissn

0041-1132

issn

1537-2995

journal_volume

52 Suppl 1

pub_type

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