Meropenem-induced immune thrombocytopenia and the diagnostic process of laboratory testing.

Abstract:

BACKGROUND:Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. CASE REPORT:A 59-year-old male patient developed severe thrombocytopenia 8 days after the administration of meropenem and cefoperazone-sulbactam. After other causes were ruled out, DITP was suspected. Drug-induced platelet (PLT) antibodies were detected by enzyme immunoassay, flow cytometry, and monoclonal antibody immobilization of PLT antigens (MAIPA). All these tests were performed in the presence and absence of the associated drugs. RESULTS:PLT antibodies were detected in the patient's serum only in the presence of meropenem. MAIPA experiments demonstrated that glycoprotein IIb/IIIa was the binding site of the meropenem-induced PLT antibodies. CONCLUSIONS:Drug-induced immune thrombocytopenia should be considered in cases of acute thrombocytopenia in patients undergoing meropenem treatment. Clinicians should be cognizant of DITP, and a definitive diagnosis should be pursued, if feasible.

journal_name

Transfusion

journal_title

Transfusion

authors

Huang R,Cai GQ,Zhang JH,Liu FX,Ma JQ,Liu H,Nie XM,Gui R

doi

10.1111/trf.14267

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

2715-2719

issue

11

eissn

0041-1132

issn

1537-2995

journal_volume

57

pub_type

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    更新日期:2019-02-01 00:00:00

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    pub_type: 历史文章,杂志文章

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    更新日期:2009-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41111426.x

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    更新日期:2001-11-01 00:00:00