Abstract:
PURPOSE:To determine the efficacy and tolerance of ultrasonography (US)-guided percutaneous radiofrequency (RF) ablation with endocrine therapy in elderly patients with breast cancer who decline or are not candidates for surgery. MATERIALS AND METHODS:Internal ethics committee approval was obtained, and patients gave informed written consent. Women older than 70 years with breast carcinoma, who had undergone neoadjuvant endocrine therapy within the past 6 months, underwent US-guided RF ablation while under local anesthesia and sedation. Only tumors measuring 3 cm or smaller and situated at least 1 cm from the skin, nipple, and chest wall were selected. Multitine electrodes were used. Endocrine therapy was continued for a total of 5 years, and breast irradiation was not performed. Clinical follow-up included US, mammography, and dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging every 2 months for 6 months and then every 6 months until 5 years. Primary end points were RF ablation efficacy at 1 year on the basis of DCE MR imaging follow-up and procedural tolerance. The secondary end point was delayed local efficacy at the end of endocrine therapy (5 years) on the basis of DCE MR imaging follow-up. RESULTS:Twenty-one women were treated from December 2004 to April 2010 (median age, 79 years; age range, 70-88 years). Efficacy was demonstrated at 1 year, with only one patient presenting with a local relapse. No general complications were noted. Skin burn occurred in four patients, with spontaneous healing after a maximum of 2 months. Ten patients were followed up for 5 years, with three additional patients presenting with cancer recurrence outside the ablation zone at 30, 48, and 60 months-including two with lobular carcinoma. Four patients died during the full follow-up, two of breast cancer-related causes and two of unrelated causes. CONCLUSION:RF ablation in elderly patients with nonresected breast cancer is well tolerated and efficient at 1-year follow-up. The technique is not recommended for lobular carcinoma.
journal_name
Radiologyjournal_title
Radiologyauthors
Palussière J,Henriques C,Mauriac L,Asad-Syed M,Valentin F,Brouste V,Mathoulin-Pélissier S,Tunon de Lara C,Debled Mdoi
10.1148/radiol.12111303subject
Has Abstractpub_date
2012-08-01 00:00:00pages
597-605issue
2eissn
0033-8419issn
1527-1315pii
radiol.12111303journal_volume
264pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To evaluate the diagnostic performance of contrast material-enhanced magnetic resonance (MR) angiography for preoperative detection and localization of accessory pudendal arteries (APAs) in patients with prostate cancer. MATERIALS AND METHODS:This prospective study was approved by the institutional review boar...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11110934
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:To develop a semiquantitative magnetic resonance (MR) imaging bone marrow burden (BMB) score with inclusion of both axial and peripheral bone marrow in Gaucher disease as an alternative to MR imaging with the Dixon quantitative chemical shift imaging (QCSI) technique. MATERIALS AND METHODS:Two experienced musc...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2292020296
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To determine the effect of the interpretation of plain chest radiographs on the time to definitive diagnosis of aortic dissection. MATERIALS AND METHODS:The authors evaluated chest radiographs from 75 patients in whom chest radiography was performed before aortic dissection was diagnosed. The radiographs and a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.193.3.7972830
更新日期:1994-12-01 00:00:00
abstract::The imaging characteristics of microcalcifications in both benign and malignant breast conditions were analyzed in 48 digitized film mammograms. Each case included in this analysis had findings considered suggestive of malignancy by the radiologist, with the underlying histologic structure determined by excisional bio...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.169.2.3174980
更新日期:1988-11-01 00:00:00
abstract::Times of maximal involvement in mouse skin were determined for reactions produced by graded doses of x irradiation combined with hyperthermic treatment at 37.5, 41, 42, 42.5 and 43 degrees C for one hour. The times of maximal involvement in each case were found to be independent of thermal treatment. These data provid...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/119.2.475
更新日期:1976-05-01 00:00:00
abstract:PURPOSE:To determine whether enhancement at multiphasic multidetector computed tomography (CT) can help differentiate clear cell renal cell carcinoma (RCC) from oncocytoma, papillary RCC, and chromophobe RCC. MATERIALS AND METHODS:With institutional review board approval for this HIPAA-compliant retrospective study, t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.13112617
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To determine the clinical feasibility of a contrast material--enhanced two-dimensional (2D) magnetic resonance (MR) angiographic sequence in lower extremity arteries. MATERIALS AND METHODS:Four healthy volunteers and 12 patients underwent dynamic contrast-enhanced MR angiography; all patients also underwent co...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.196.3.7644630
更新日期:1995-09-01 00:00:00
abstract::The authors retrospectively evaluated 12 patients with congenital (neonatal) neuroblastoma to assess the utility of newer imaging modalities. Findings at prenatal ultrasound (US), performed in four patients, were nonspecific (hydramnios and hydrops fetalis) in two and consistent with a suprarenal mass (one solid, one ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.175.2.2183280
更新日期:1990-05-01 00:00:00
abstract:PURPOSE:To estimate the fraction of moving blood in tissue with power Doppler ultrasound (US). MATERIALS AND METHODS:Power Doppler US measurements of moving scatterers in a flow tube were made as a function of successive dilutions of the perfusate. Measurements were normalized relative to the maximum Doppler power in ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.197.1.7568820
更新日期:1995-10-01 00:00:00
abstract::The blood supplies of nodular lesions associated with liver cirrhosis were analyzed in vivo with various imaging modalities. The portal blood supply was evaluated with computed tomography (CT) during arterial portography (CTAP); the arterial blood supply was evaluated with hepatic angiography, CT angiography, CT follo...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.178.2.1846240
更新日期:1991-02-01 00:00:00
abstract::To reduce radiation exposure to patients and staff during neurointerventional procedures, region-of-interest (ROI) techniques were used with fluoroscopy, road mapping, and digital subtraction angiography in 19 patients. ROI filters, made of multiple layers of gadolinium, were attached to the collimators. Patient skin ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.199.3.8638020
更新日期:1996-06-01 00:00:00
abstract::Steeple-shaped shadows adjacent to the diaphragm are common in upper lobe collapse due to a variety of causes. They call attention to upper lobe collapse and should not be considered indicative of intrinsic lower lobe abnormality. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.134.3.7355230
更新日期:1980-03-01 00:00:00
abstract:PURPOSE:To evaluate prospectively bolus tracking to time hepatic arterial phase (HAP) imaging of hypervascular hepatocellular carcinomas (HCCs) with a 40-detector computed tomographic (CT) scanner. MATERIALS AND METHODS:This study received institutional review board approval; informed consent was obtained. The study i...
journal_title:Radiology
pub_type: 杂志文章,随机对照试验
doi:10.1148/radiol.2431060069
更新日期:2007-04-01 00:00:00
abstract::The authors describe three pediatric patients with diffuse pulmonary hemangiomatosis. Virtually identical clinical, radiographic, and pathologic findings were observed in each case. The combination of diffuse interstitial pulmonary infiltration and bloody pleural effusion in a child is pathognomonic. Early recognition...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/127.2.445
更新日期:1978-05-01 00:00:00
abstract::Renal allografts are subject to many vascular complications. Over a 2-year period, 334 duplex Doppler ultrasonographic (US) examinations were performed in 88 renal allograft recipients. Vascular occlusion on the basis of severe vascular rejection was documented in ten patients (11.4%) for a sensitivity and specificity...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.162.1.3538150
更新日期:1987-01-01 00:00:00
abstract::Four cases of severe skin reactions to the use of iocetamic acid as a contrast medium are reported. Although the incidence of this type of reaction was relatively small (1.8%), its severity induced the authors to discontinue the use of this medium. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/118.2.301
更新日期:1976-02-01 00:00:00
abstract:PURPOSE:To retrospectively compare the sensitivity of a computer-aided detection (CAD) system for depicting breast cancer in three digital mammographic views. MATERIALS AND METHODS:This study was conducted with institutional review board approval; informed consent was waived. A commercially available CAD system was ap...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2413051145
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:To determine the diagnostic accuracy of breath-hold, contrast material-enhanced, three-dimensional (3D) magnetic resonance (MR) angiography in the assessment of the aortoiliac inflow tract and renal arteries with conventional catheter angiography as the standard of reference. MATERIALS AND METHODS:In 39 patien...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.204.2.9240520
更新日期:1997-08-01 00:00:00
abstract:PURPOSE:To assess the diagnostic value of spinal ultrasonography (US) in pediatric patients. MATERIALS AND METHODS:The findings on 38 spinal US scans in 30 patients (mean age, 5.5 months) were compared with those of corresponding magnetic resonance (MR) images. RESULTS:MR imaging showed a normal spinal canal in 14 of...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.200.2.8685330
更新日期:1996-08-01 00:00:00
abstract:PURPOSE:To evaluate toxicity and efficacy of endobronchial brachytherapy with high-dose-rate (HDR) after-loading of iridium-192 for recurrent endobronchial lesions. MATERIALS AND METHODS:From 1988 to 1993, 81 patients with lung cancer previously treated with external beam radiation therapy were treated with palliative...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.201.1.8816560
更新日期:1996-10-01 00:00:00
abstract::The authors describe mammographic and pathologic evidence of the growth of a fibroadenoma in an 82-year-old obese woman, 44 years after menopause, who had never been treated with hormone therapy. The patient's obesity is hypothesized as the causal factor for increased estrogen levels leading to growth of the fibroaden...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.184.2.1620840
更新日期:1992-08-01 00:00:00
abstract:PURPOSE:To prospectively assess which phase of a triple-phase dynamic contrast material-enhanced multi-detector row computed tomography (CT) protocol is optimal for visualization of esophageal cancer. MATERIALS AND METHODS:The study was supported by the local ethical committee; all patients gave written informed conse...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2393050222
更新日期:2006-06-01 00:00:00
abstract::The distal small-bowel loops in the pelvis do not always lend themselves to palpation of easy visualization during conventional small-bowel examinations. When this occurs, an angled view of the pelvis, such as that used to uncoil the sigmoid colon during barium-enema examinations, can separate these overlapping segmen...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.144.2.7089300
更新日期:1982-07-01 00:00:00
abstract::The chest radiographs of asthmatic patients in an emergency room setting over a four-year period were reviewed. A total of 997 radiographs was reviewed; radiographic findings were compared with history and clinical data. In adults 2.2% of the radiographs were abnormal; in children 13%. It is concluded that a chest rad...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.145.1.7122890
更新日期:1982-10-01 00:00:00
abstract:PURPOSE:To retrospectively determine whether there is a relationship between the intranodular blood supply evaluated at computed tomography (CT) during arterial portography (CTAP) and CT during hepatic arteriography (CTHA) and the magnetic resonance (MR) imaging signal intensity of nodules associated with cirrhosis. M...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2372041389
更新日期:2005-11-01 00:00:00
abstract::Studies of 23 pediatric patients with pachygyriclike changes (PLCs) examined with computed tomography (CT) and magnetic resonance (MR) imaging were reviewed to determine topographic patterns and correlate them with various clinical syndromes and degrees of neurologic impairment. Three types of topographic distribution...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.173.3.2554360
更新日期:1989-12-01 00:00:00
abstract::Californium 252 low dose rate intracavitary neutron implants combined with conventional external beam therapy for advanced pelvic tumors produced better local response than 137Cs in pelvic brachytherapy. Greater tumor regression was achieved by applying 252Cf while the maximum amount of tumor was present preceding or ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/133.2.473
更新日期:1979-11-01 00:00:00
abstract::High-resolution real-time ultrasound with either a 7.5- or 10-MHz transducer was used to localize 7/9 nonpalpable breast masses previously detected by mammography and to determine where the biopsy needle should be inserted. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.151.3.6718740
更新日期:1984-06-01 00:00:00
abstract::History A 57-year-old woman presented with right breast swelling and enlargement and a palpable mass in the right lower inner breast. There was no history of fever, trauma, skin redness, or nipple discharge. The patient had a history of breast augmentation, with retropectoral silicone implants placed 2.5 years ago. Sc...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018160440
更新日期:2018-08-01 00:00:00
abstract::Transient sonographic abnormalities of the urinary bladder in children can be identified immediately after performance of voiding cystourethrography. Both cystic and solid masses may be mimicked by transient hematuria induced by minor, cystography-related trauma. After the bladder has been emptied and refilled, reexam...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.159.1.3513250
更新日期:1986-04-01 00:00:00