Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT.

Abstract:

PURPOSE:To determine whether enhancement at multiphasic multidetector computed tomography (CT) can help differentiate clear cell renal cell carcinoma (RCC) from oncocytoma, papillary RCC, and chromophobe RCC. MATERIALS AND METHODS:With institutional review board approval for this HIPAA-compliant retrospective study, the pathology database was queried to derive a cohort of 298 cases of RCC and oncocytoma with preoperative multiphasic multidetector CT with as many as four phases (unenhanced, corticomedullary, nephrographic, and excretory). A total of 170 clear cell RCCs, 57 papillary RCCs, 49 oncocytomas, and 22 chromophobe RCCs were evaluated for multiphasic enhancement and compared by using t tests. Cutoff analysis was performed to determine optimal threshold levels to discriminate among the four groups. RESULTS:Mean enhancement of clear cell RCCs and oncocytomas peaked in the corticomedullary phase; mean enhancement of papillary and chromophobe RCCs peaked in the nephrographic phase. Enhancement of clear cell RCCs was greater than that of oncocytomas in the corticomedullary (125 HU vs 106 HU, P = .045) and excretory (80 HU vs 67 HU, P = .034) phases. Enhancement of clear cell RCCs was greater than that of papillary RCCs in the corticomedullary (125 HU vs 54 HU, P < .001), nephrographic (103 HU vs 64 HU, P < .001), and excretory (80 HU vs 54 HU, P < .001) phases. Enhancement of clear cell RCCs was greater than that of chromophobe RCCs in the corticomedullary (125 HU vs 74 HU, P < .001) and excretory (80 HU vs 60 HU, P = .008) phases. Thresholding of enhancement helped to discriminate clear cell RCC from oncocytoma, papillary RCC, and chromophobe RCC with accuracies of 77% (83 of 108 cases), 85% (101 of 119 cases), and 84% (81 of 97 cases). CONCLUSION:Enhancement at multiphasic multidetector CT, if prospectively validated, may assist in the discrimination of clear cell RCC from oncocytoma, papillary RCC, and chromophobe RCC.

journal_name

Radiology

journal_title

Radiology

authors

Young JR,Margolis D,Sauk S,Pantuck AJ,Sayre J,Raman SS

doi

10.1148/radiol.13112617

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

444-53

issue

2

eissn

0033-8419

issn

1527-1315

pii

radiol.13112617

journal_volume

267

pub_type

杂志文章
  • Prostaglandin E1 as a pharmacoangiographic agent for arterial portography.

    abstract::The effects of increasing single selective doses of prostaglandin E1 (PGE1) on superior mesenteric arterial flow and portal and systemic blood pressures were studied in dogs to assess its value as a vasodilatory agent for pharmacoangiography. PGE1 consistently increased blood flow, with an average increase of 187%, bu...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/116.1.207

    authors: Cho KJ,Chuang VP,Reuter SR

    更新日期:1975-07-01 00:00:00

  • Peritoneocele: visualization with defecography and peritoneography performed simultaneously.

    abstract:PURPOSE:To evaluate the use of simultaneous defecography and peritoneography (defecoperitoneography) in patients with an unexplained widening of the rectovaginal space noted at defecography. MATERIALS AND METHODS:Twenty-two patients with unexplained widening of the rectovaginal space noted at defecography were studied...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.202.2.9015060

    authors: Bremmer S,Mellgren A,Holmström B,López A,Udén R

    更新日期:1997-02-01 00:00:00

  • Stage A adenocarcinoma of the prostate: transrectal US and sonographic-pathologic correlation.

    abstract::Results of transrectal ultrasound (TRUS) of the prostate and pathologic examination of specimens obtained at transurethral resection of the prostate (TURP) were compared in 29 patients with clinical stage A adenocarcinoma. Ten specimens contained no residual tumors larger than 5 mm in diameter; in the remaining 19 gla...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.179.1.2006300

    authors: Sheth S,Hamper UM,Walsh PC,Holtz PM,Epstein JI

    更新日期:1991-04-01 00:00:00

  • Repeatability of quantitative CT indexes of emphysema in patients evaluated for lung volume reduction surgery.

    abstract:PURPOSE:To evaluate the repeatability of quantitative computed tomographic (CT) indexes of emphysema and the effect of spirometric gating of lung volume during CT in candidates for lung volume reduction surgery (LVRS). MATERIALS AND METHODS:Initial and same-day repeat routine inspiratory spiral chest CT studies were p...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.220.2.r01au46448

    authors: Gierada DS,Yusen RD,Pilgram TK,Crouch L,Slone RM,Bae KT,Lefrak SS,Cooper JD

    更新日期:2001-08-01 00:00:00

  • Circumferential Thick Enhancement at Vessel Wall MRI Has High Specificity for Intracranial Aneurysm Instability.

    abstract::Purpose To identify wall enhancement patterns on vessel wall MRI that discriminate between stable and unstable unruptured intracranial aneurysm (UIA). Materials and Methods Patients were included from November 2012 through January 2016. Vessel wall MR images were acquired at 3 T in patients with stable (incidental and...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2018172879

    authors: Edjlali M,Guédon A,Ben Hassen W,Boulouis G,Benzakoun J,Rodriguez-Régent C,Trystram D,Nataf F,Meder JF,Turski P,Oppenheim C,Naggara O

    更新日期:2018-10-01 00:00:00

  • Improved prognosis of women aged 75 and older with mammography-detected breast cancer.

    abstract:PURPOSE:To evaluate the characteristics and outcomes of women aged 75 years and older with mammography-detected breast cancer, an age group not represented in mammography screening effectiveness studies. MATERIALS AND METHODS:We conducted a HIPAA-compliant, prospective cohort study with waiver of informed consent in p...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14140209

    authors: Malmgren JA,Parikh J,Atwood MK,Kaplan HG

    更新日期:2014-12-01 00:00:00

  • Central nervous system tumors in children: detection by magnetic resonance imaging.

    abstract::Fifty-one pediatric patients who were suspected of having central nervous system (CNS) tumors underwent magnetic resonance (MR) imaging using a 0.35 T Diasonics MT/S system. Pulse intervals (TR) ranged from 0.5 to 2.0 seconds with echo delays (TE) of 28 and 56 msec. The ability of MR and contrast-enhanced CT to detect...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.155.1.3975390

    authors: Kucharczyk W,Brant-Zawadzki M,Sobel D,Edwards MB,Kelly WM,Norman D,Newton TH

    更新日期:1985-04-01 00:00:00

  • Combat-related Mild Traumatic Brain Injury: Association between Baseline Diffusion-Tensor Imaging Findings and Long-term Outcomes.

    abstract::Purpose To determine whether functional outcomes of veterans who sustained combat-related mild traumatic brain injury (TBI) are associated with scalar metrics derived from diffusion-tensor (DT) imaging at their initial postdeployment evaluation. Materials and Methods This HIPAA-compliant retrospective study was approv...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2016151013

    authors: Ware JB,Biester RC,Whipple E,Robinson KM,Ross RJ,Nucifora PG

    更新日期:2016-07-01 00:00:00

  • Barium enema examination using a remote controlled positive and negative contrast media inflator.

    abstract::In a series of 30 patients, barium enema examination of the colon was performed via a remote controlled air and contrast media inflator. With this apparatus, introduction and elimination of air and barium into the colon can be accomplished at a freely adjustable rate of injection by remote control. Fluoroscopy time is...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/125.2.533

    authors: Hisamichi S,Masuda Y,Shirane A,Sugawara N,Gomi T,Oshiba S

    更新日期:1977-11-01 00:00:00

  • Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging.

    abstract:PURPOSE:To evaluate the accuracy of technetium-99m sestamibi as a single agent in the detection and localization of hyperfunctioning parathyroid tissue in patients who underwent prior neck exploration or who otherwise are high surgical risks. MATERIALS AND METHODS:Thirty-nine patients with hyperparathyroidism underwen...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.197.3.7480730

    authors: Lee VS,Wilkinson RH Jr,Leight GS Jr,Coogan AC,Coleman RE

    更新日期:1995-12-01 00:00:00

  • Hilar lymph nodes: identification with spiral CT and histologic correlation.

    abstract:PURPOSE:To determine the appearance of normal hilar lymph nodes and associated soft tissue at spiral computed tomography (CT). MATERIALS AND METHODS:At spiral CT in 50 healthy patients, peribronchovascular hypoattenuated areas of 42 right and 45 left hila were systematically evaluated. Histologic results were correlat...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.196.2.7617850

    authors: Remy-Jardin M,Duyck P,Remy J,Petyt L,Wurtz A,Mensier E,Copin MC,Riquet M

    更新日期:1995-08-01 00:00:00

  • Biliary tract depiction in living potential liver donors: comparison of conventional MR, mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography--initial experience.

    abstract:PURPOSE:To compare biliary tract depiction in living potential liver donors at conventional magnetic resonance (MR), mangafodipir trisodium-enhanced excretory MR, and multi-detector row computed tomographic (CT) cholangiography. MATERIALS AND METHODS:Eight living potential liver donors underwent iodipamide meglumine-e...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2303021775

    authors: Yeh BM,Breiman RS,Taouli B,Qayyum A,Roberts JP,Coakley FV

    更新日期:2004-03-01 00:00:00

  • Ear, nose, and throat cancer: ultrasound diagnosis of metastasis to cervical lymph nodes.

    abstract::We present the results of a study on the value of ultrasound in the detection of metastasis to the cervical lymph nodes in connection with cancer of the ear, nose, and throat. Comparison of clinical, ultrasound, and histological findings for 100 patients who underwent surgery revealed that clinical examination had a s...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.152.3.6463260

    authors: Bruneton JN,Roux P,Caramella E,Demard F,Vallicioni J,Chauvel P

    更新日期:1984-09-01 00:00:00

  • Color Doppler US in the evaluation of acute scrotal disease.

    abstract::Twenty-seven patients presented with painful acute scrotal swelling. After a clinical impression was established, all patients underwent diagnostic imaging with color Doppler ultrasound (US). Seven patients underwent surgical exploration for testicular torsion diagnosed with color Doppler US (100% operative confirmati...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.176.2.2195590

    authors: Lerner RM,Mevorach RA,Hulbert WC,Rabinowitz R

    更新日期:1990-08-01 00:00:00

  • Does radiologist recommendation for follow-up with the same imaging modality contribute substantially to high-cost imaging volume?

    abstract:PURPOSE:To retrospectively measure repeat rates for high-cost imaging studies, determining their causes and trends, and the impact of radiologist recommendations for a repeat examination on imaging volume. MATERIALS AND METHODS:This HIPAA-compliant study had institutional review board approval, with waiver of informed...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2423051754

    authors: Lee SI,Saokar A,Dreyer KJ,Weilburg JB,Thrall JH,Hahn PF

    更新日期:2007-03-01 00:00:00

  • Hepatic hemangiomas and malignant tumors: improved differentiation with heavily T2-weighted conventional spin-echo MR imaging.

    abstract:PURPOSE:To determine whether hemangiomas and malignant tumors can be better differentiated at 1.5-T magnetic resonance imaging with use of more heavily T2-weighted conventional spin-echo sequences. MATERIALS AND METHODS:Eighty-three patients with focal liver lesions (50 malignant tumors, 24 hemangiomas, nine cysts) la...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.193.1.8090920

    authors: McFarland EG,Mayo-Smith WW,Saini S,Hahn PF,Goldberg MA,Lee MJ

    更新日期:1994-10-01 00:00:00

  • Gastric polyps on routine double-contrast examination of the stomach.

    abstract::Gastric polyps were found in 38 patients in a series of 2,420 consecutive double-contrast studies of the upper gastrointestinal tract. The resulting incidence of 1.6% is four times the highest figure previously reported. Single polyps were usually located in the antrum, multiple polyps in the body of fundus. Two-third...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.134.1.7350630

    authors: Gordon R,Laufer I,Kressel HY

    更新日期:1980-01-01 00:00:00

  • The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden.

    abstract:PURPOSE:To evaluate differences in the structural connectome among patients with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer disease (AD) and to determine associations between the structural connectome and cortical amyloid deposition. MATERIALS AND METHODS:Patients enrolled in a multicenter b...

    journal_title:Radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1148/radiol.14132593

    authors: Prescott JW,Guidon A,Doraiswamy PM,Roy Choudhury K,Liu C,Petrella JR,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2014-10-01 00:00:00

  • Percutaneous image-guided cutting-needle biopsy of the pleura in the presence of a suspected malignant effusion.

    abstract:PURPOSE:To evaluate the diagnostic accuracy of percutaneous image-guided cutting-needle biopsy of pleural thickening in the presence of a suspected malignant pleural effusion. MATERIALS AND METHODS:Thirty-three adult patients with diffuse or focal pleural thickening (median, 1.0 cm; range, 0.2-6.0 cm), pleural effusio...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.219.2.r01ma07510

    authors: Adams RF,Gleeson FV

    更新日期:2001-05-01 00:00:00

  • Carotid angioplasty and stent placement: comparison of transcranial Doppler US data and clinical outcome with and without filtering cerebral protection devices in 509 patients.

    abstract:PURPOSE:To prospectively evaluate emboli detected at transcranial Doppler ultrasonography (US) and outcome of carotid angioplasty and stent placement and compare these findings in patients treated with the use of filtering cerebral protection devices (CPDs) with the findings in patients treated without the use of filte...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2342040119

    authors: Vos JA,van den Berg JC,Ernst SM,Suttorp MJ,Overtoom TT,Mauser HW,Vogels OJ,van Heesewijk HP,Moll FL,van der Graaf Y,Mali WP,Ackerstaff RG

    更新日期:2005-02-01 00:00:00

  • Aortobronchial fistula as a complication of surgery for correction of congenital aortic anomalies.

    abstract::An aortobronchial fistula is a rare condition that is invariably fatal if not diagnosed and surgically treated. Aortic aneurysms, both atherosclerotic and infective, were the main causes in the originally described cases. However, thoracic cardiovascular surgery has recently become the predominant cause. The authors d...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.175.2.2326460

    authors: Garniek A,Morag B,Schmahmann S,Rubinstein ZJ

    更新日期:1990-05-01 00:00:00

  • Brachytherapy for prophylaxis of restenosis after long-segment femoropopliteal angioplasty: pilot study.

    abstract:PURPOSE:To evaluate in a pilot study the feasibility and efficacy of endovascular brachytherapy for prophylaxis of restenosis after femoropopliteal percutaneous transluminal angioplasty (PTA) without stent implantation in a group of patients with a high risk of restenosis. MATERIALS AND METHODS:Ten patients (six women...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.208.1.9646810

    authors: Minar E,Pokrajac B,Ahmadi R,Maca T,Seitz W,Stümpflen A,Pötter R,Ehringer H

    更新日期:1998-07-01 00:00:00

  • The RSNA Pediatric Bone Age Machine Learning Challenge.

    abstract::Purpose The Radiological Society of North America (RSNA) Pediatric Bone Age Machine Learning Challenge was created to show an application of machine learning (ML) and artificial intelligence (AI) in medical imaging, promote collaboration to catalyze AI model creation, and identify innovators in medical imaging. Materi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2018180736

    authors: Halabi SS,Prevedello LM,Kalpathy-Cramer J,Mamonov AB,Bilbily A,Cicero M,Pan I,Pereira LA,Sousa RT,Abdala N,Kitamura FC,Thodberg HH,Chen L,Shih G,Andriole K,Kohli MD,Erickson BJ,Flanders AE

    更新日期:2019-02-01 00:00:00

  • CT colonography: a systematic review of standard of reporting for studies of computer-aided detection.

    abstract:PURPOSE:To determine objectively the current standard of reporting for studies of computer-aided detection (CAD) for computed tomographic (CT) colonography by systematically reviewing published articles. MATERIALS AND METHODS:MEDLINE was searched to identify study articles meeting the inclusion criteria for describing...

    journal_title:Radiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1148/radiol.2461070121

    authors: Robinson C,Halligan S,Taylor SA,Mallett S,Altman DG

    更新日期:2008-02-01 00:00:00

  • Surface coil MR imaging of abdominal viscera. Part I. Theory, technique, and initial results.

    abstract::Prototype surface coil magnetic resonance (MR) images were obtained from phantoms and 42 subjects at 0.6 T to assess the feasibility of imaging relatively deep abdominal structures. Surface coil images demonstrated a two- to fourfold improvement in signal-to-noise ratio (SNR) when compared with whole-body coil images ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.157.2.4048450

    authors: Edelman RR,McFarland E,Stark DD,Ferrucci JT Jr,Simeone JF,Wismer G,White EM,Rosen BR,Brady TJ

    更新日期:1985-11-01 00:00:00

  • Perforated appendix presenting with severe diarrhea. Findings on barium-enema examination.

    abstract::Severe diarrhea and marked lower abdominal cramps are unusual manifestations of appendicitis. The authors performed a barium-enema examination (BE) on 9 pediatric patients who were ultimately shown to have a perforated appendix and pelvic abscesses. In 8 cases, the atypical symptoms initially led to an incorrect clini...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.1.6611920

    authors: Picus D,Shackelford GD

    更新日期:1983-10-01 00:00:00

  • New techniques in lumbar spinal instrumentation: what the radiologist needs to know.

    abstract::Lumbar spinal fusion is a commonly performed procedure, and, despite changes in cage types and fixation hardware, radiologists have, over the years, become familiar with the imaging features of typical spinal fusion and many of the complications seen in patients after surgery, including pseudoarthrosis, hardware loose...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiol.11101104

    authors: Murtagh RD,Quencer RM,Castellvi AE,Yue JJ

    更新日期:2011-08-01 00:00:00

  • Corticospinal tract localization: integration of diffusion-tensor tractography at 3-T MR imaging with intraoperative white matter stimulation mapping--preliminary results.

    abstract::Institutional review board approval and written informed consent were obtained. The purpose of this study was to prospectively validate usefulness of diffusion-tensor (DT) fiber tractography of the corticospinal tract at 3-T magnetic resonance imaging, in combination with the subcortical motor-evoked potential (MEP) t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2403050916

    authors: Okada T,Mikuni N,Miki Y,Kikuta K,Urayama S,Hanakawa T,Fushimi Y,Yamamoto A,Kanagaki M,Fukuyama H,Hashimoto N,Togashi K

    更新日期:2006-09-01 00:00:00

  • Digital tomosynthesis in breast imaging.

    abstract:PURPOSE:To describe and evaluate a method of tomosynthesis breast imaging with a full-field digital mammographic system. MATERIALS AND METHODS:In this tomosynthesis method, low-radiation-dose images were acquired as the x-ray source was moved in an arc above the stationary breast and digital detector. A step-and-expos...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.205.2.9356620

    authors: Niklason LT,Christian BT,Niklason LE,Kopans DB,Castleberry DE,Opsahl-Ong BH,Landberg CE,Slanetz PJ,Giardino AA,Moore R,Albagli D,DeJule MC,Fitzgerald PF,Fobare DF,Giambattista BW,Kwasnick RF,Liu J,Lubowski SJ,Possin G

    更新日期:1997-11-01 00:00:00

  • Benign breast lesions: ultrasound detection and diagnosis.

    abstract::Experience with 2500 patients over age 30 studied by physical examination, x-ray mammography, and sonography enabled definition of several specific clinical situations in which sonography adds meaningful diagnostic information not provided by either of the other examinations. These include: palpable breast masses for ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.151.2.6709920

    authors: Sickles EA,Filly RA,Callen PW

    更新日期:1984-05-01 00:00:00