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Hypervascular hepatocellular carcinomas: bolus tracking with a 40-detector CT scanner to time arterial phase imaging.

Abstract：

PURPOSE:To evaluate prospectively bolus tracking to time hepatic arterial phase (HAP) imaging of hypervascular hepatocellular carcinomas (HCCs) with a 40-detector computed tomographic (CT) scanner. MATERIALS AND METHODS:This study received institutional review board approval; informed consent was obtained. The study included 192 patients (123 men, 69 women; mean age, 67.6 years) with known or suspected HCC who underwent dynamic CT, including HAP scanning; CT depicted 111 hypervascular HCCs in 72 patients. Scanning was performed with a 40-detector CT scanner, and bolus tracking was used to time the start of HAP imaging. Patients were randomly assigned to five protocols; HAP scanning was started at a specified interval after trigger threshold was reached: 9 seconds (protocol A), 12 seconds (protocol B), 15 seconds (protocol C), 18 seconds (protocol D), or 21 seconds (protocol E). Trigger threshold level was set at 100 HU above aortic baseline CT number. Enhancement values in the aorta and the tumor-liver contrast (TLC) were measured. Dunnett multiple comparisons were performed to compare enhancement values among the five protocols. RESULTS:Mean scanning time for the whole liver was 2.1 seconds. Mean enhancement value of the aorta in protocols A, B, C, D, and E were 284.3 HU +/- 54.7, 293.8 HU +/- 51.0, 308.7 HU +/- 55.9, 291.5 HU +/- 42.2, and 235.5 HU +/- 51.2, respectively. Aortic enhancement was significantly lower in protocol E than in protocol A (P < .01); there was no significant difference between protocols A and B, A and C, and A and D. Mean TLCs in protocols A, B, C, D, and E were 23.4 HU +/- 7.6, 35.5 HU +/- 14.0, 36.2 HU +/- 6.8, 47.2 HU +/- 19.2, and 35.1 HU +/- 15.8, respectively. A significant difference was found only between protocols A and D (P < .01). CONCLUSION:Peak TLC during the HAP occurred 18 seconds after triggering.

journal_name

Radiology

journal_title

Radiology

authors

Sultana S,Awai K,Nakayama Y,Nakaura T,Liu D,Hatemura M,Funama Y,Morishita S,Yamashita Y

doi

10.1148/radiol.2431060069

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

140-7

issue

eissn

0033-8419

issn

1527-1315

pii

2431060069

journal_volume

243

pub_type

杂志文章,随机对照试验

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Hypervascular hepatocellular carcinomas: bolus tracking with a 40-detector CT scanner to time arterial phase imaging.